TDZD-8 - Moligand™, 10mM in DMSO , Inhibitor of glycogen synthase kinase 3 beta, CAS No.327036-89-5, Inhibitor of glycogen synthase kinase 3 beta

CAS: 327036-89-5 Cat. No.: T409003 Fórmula: C₁₀H₁₀N₂O₂S Peso molecular: 222.26 Número EC: 636-505-3 PubChem CID: 4124851

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

NP 01139 | 1,2,4-Thiadiazolidine-3,5-dione, 2-methyl-4-(phenylmethyl)-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Information

TDZD-8 (NP 01139) is a non-ATP competitiveGSK-3βinhibitor withIC50of 2 μM; minimal inhibitory effect observed on CDK1, casein kinase II, PKA and PKC.
In vitro

TDZD-8 acts as a noncompetitive inhibitor of ATP or GS-1 binding. TDZD-8 shows no inhibition of PKA, PKC, Cdk-1/cyclin B or CK-II in kinase assays. TDZD-8 specifically induces cell death of primary leukemia specimens. TDZD-8 ablates leukemia progenitor and stem cells. TDZD-8 treatment induces oxidative stress. TDZD-8 induces cell death with extremely rapid cell death kinetics showing loss of membrane integrity. TDZD-8 inhibits PKC and FLT3 in primary AML specimens.

In vivo

Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Sinónimos

NP 01139 | 1,2,4-Thiadiazolidine-3,5-dione, 2-methyl-4-(phenylmethyl)-

Especificaciones y pureza

Moligand™, 10mM in DMSO

Mecanismos bioquímicos y fisiológicos

TDZD-8 (NP 01139) is a non-ATP competitive GSK-3β inhibitor with IC50 of 2 μM; minimal inhibitory effect observed on CDK1, casein kinase II, PKA and PKC.

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Grado

Moligand™

Tipo de acción

INHIBITOR

Mecanismo de acción

Inhibitor of glycogen synthase kinase 3 beta

Nombres e identificadores

• Isómeros SMILES: CN1C(=O)N(C(=O)S1)CC2=CC=CC=C2
• WGK Alemania: 3
• PubChem CID: 4124851
• Peso molecular: 222.26

Objetivos asociados (humanos)

GSK3B Tclin Glycogen synthase kinase-3 beta (1 Activities)

Discover Target: GSK3B

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Propiedades químicas y físicas

• Solubilidad: Solubility (25°C) In vitro Ethanol: mg/mL
• Punto de fusión (°C): 63 °C

Referencias

1. Dong Wang, Xiaona Lu, Enbo Wang, Liangang Shi, Chi Ma, Xiaodong Tan.  (2021)  Salvianolic acid B attenuates oxidative stress-induced injuries in enterocytes by activating Akt/GSK3β signaling and preserving mitochondrial function.  EUROPEAN JOURNAL OF PHARMACOLOGY,      [PMID:34364877] [10.1016/j.ejphar.2021.174408]