Tegaserod - Moligand™, 10 mM in DMSO , CAS No.145158-71-0

CAS: 145158-71-0 Cat. No.: T1496896 Molecular Weight: 301.39 PubChem CID: 135409453

GRADE & PURITY Moligand™, 10 mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Tegaserod is an orally active serotonin receptor 4 ( HTR4 ; 5-HT 4 R ) agonist and a 5-HT 2B receptor antagonist. Tegaserod has pK i s of 7.5, 8.4 and 7.0 for human recombinant 5-HT 2A , 5-HT 2B and 5-HT 2C receptors, respectively. Tegaserod causes tumor cell apoptosis , blunts PI3K/Akt/mTOR signaling and decreases S6 phosphorylation. Tegaserod has anti-tumor activity and has the potential for irritable bowel syndrome (IBS) research.

Specifications

Specifications & Purity

Moligand™, 10 mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Product Properties

• pKa: pKₐ: 9.65 (Predicted)
• Ki Data: SR-4: Ki= 3.98 nM (human); SR-3A: Ki>10 μM (human)

Names and Identifiers

• Isomeric SMILES: CCCCCN=C(N)N/N=C/C1=CNC2=C1C=C(C=C2)OC
• PubChem CID: 135409453
• Molecular Weight: 301.39

Chemical and Physical Properties

• Refractive Index: n20D1.60 (Predicted)
• Boil Point(°C): ~470.6° C at 760 mmHg (Predicted)
• Melt Point(°C): 198.15° C (Predicted)