Thiolutin - ≥95% , CAS No.87-11-6

Name: Thiolutin - ≥95% , CAS No.87-11-6
Brand: Aladdin Scientific
SKU: T102393
Availability: InStock

CAS: 87-11-6 Cat. No.: T102393 Molecular Weight: 228.29 EC Number: 635-840-2 PubChem CID: 6870

1 Citations COA

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Thiolutin - ≥95% CAS No(87-11-6) by Aladdin Scientific

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AVAILABLE TO ORDER

GRADE & PURITY ≥95%

Synonyms

AS-72926 | 3-Acetamido-5-methylpyrrolin-4-one(4,3-d)-1,2-dithiole | 1,2-DITHIOLO(4,3-B)PYRROL-5(4H)-ONE, 6-ACETAMIDO-4-METHYL- | NSC 3927 | 1, 6-acetamido-4-methyl- | 6-Acetamido-4-methyl-1,2-dithiolo(4,3-b)pyrrol-5(4H)-one | HY-N6712 | BRN 0209485 | N-(4

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview Specifications Names and Identifiers Documentation Advanced Data Taxonomic Classification 3D Structure Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Certificates（CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Citations of This Product References Solution Calculators Reviews

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Why this grade

≥95% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 1 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

Thiolutin is an RNA polymerase inhibitor, and a sulfur-based microbial antibiotic generated by Streptomyces sp. The compound has been shown to inhibit transcription in Saccharomyces cerevisiae and mRNA degradation. Thiolutin inhibits the adhesion of endothelial cells, including adhesion of human umbilical vein endothelial cells (HUVECs) to vitronectin, and restricts tumor cell-induced angiogenesis. Studies have reported that Thiolutin is an effective inducer of HSP 27 (heat shock protein 27; Hsp27) phosphorylation. Research shows that in the presence of Thiolutin, the interaction between Hsp27 and nestin is disrupted, which results in the breakdown of nestin filaments.
An RNA polymerase inhibitor and suppressor of tumor cell-induced angiogenesis

Specifications

Synonyms

AS-72926 | 3-Acetamido-5-methylpyrrolin-4-one(4, 3-d)-1, 2-dithiole | 1, 2-DITHIOLO(4, 3-B)PYRROL-5(4H)-ONE, 6-ACETAMIDO-4-METHYL- | NSC 3927 | 1, 6-acetamido-4-methyl- | 6-Acetamido-4-methyl-1, 2-dithiolo(4, 3-b)pyrrol-5(4H)-one | HY-N6712 | BRN 0209485 | N-(4

Specifications & Purity

≥95%

Biochemical and Physiological Mechanisms

Sulfur-based antibiotic agent. Potent RNA polymerase inhibitor. Inhibits endothelial cell adhesion (IC 50 = 0.83 μM). Suppresses tumor cell induced angiogenesis and shows antitumor effects in vivo.

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Note

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Toxic, refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Purity

≥95%

Names and Identifiers

Pubchem Sid	488180184
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488180184
Canonical Smiles	CC(=O)NC1=C2C(=CSS2)N(C1=O)C
IUPAC Name	N-(4-methyl-5-oxodithiolo[4,3-b]pyrrol-6-yl)acetamide
InChIKey	MHMRAFONCSQAIA-UHFFFAOYSA-N
INCHI	1S/C8H8N2O2S2/c1-4(11)9-6-7-5(3-13-14-7)10(2)8(6)12/h3H,1-2H3,(H,9,11)
Isomeric SMILES	CC(=O)NC1=C2C(=CSS2)N(C1=O)C
WGK Germany	3
RTECS	JP1355000
PubChem CID	6870
UN Number	2811
Molecular Weight	228.29

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organic nitrogen compounds
  - Class Organonitrogen compounds
    - Subclass N-arylamides

Kingdom	Organic compounds
Superclass	Organic nitrogen compounds
Class	Organonitrogen compounds
Subclass	N-arylamides
Intermediate Tree Nodes	Not available
Direct Parent	N-acetylarylamines
Alternative Parents	N-methylpyrroles Heteroaromatic compounds Acetamides 1,2-dithioles Secondary carboxylic acid amides Lactams Azacyclic compounds Organopnictogen compounds Organic oxides Hydrocarbon derivatives Carbonyl compounds
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	N-acetylarylamine - N-methylpyrrole - Substituted pyrrole - Pyrrole - 1,2-dithiole - Dithiole - Acetamide - Heteroaromatic compound - Carboxamide group - Secondary carboxylic acid amide - Lactam - Organoheterocyclic compound - Carboxylic acid derivative - Azacycle - Carbonyl group - Organopnictogen compound - Organooxygen compound - Organic oxygen compound - Hydrocarbon derivative - Organic oxide - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as n-acetylarylamines. These are acetamides where one or more amide hydrogens is substituted by an aryl group.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

3D Structure

Associated Targets(Human)

VDR Tclin Vitamin D receptor (26531 Activities)

Discover Target: VDR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

A498 (42825 Activities)

Lot Number	Certificate Type	Date	Item
D2318550	Certificate of Analysis	Mar 15, 2023	T102393
D2318588	Certificate of Analysis	Mar 15, 2023	T102393
D2318589	Certificate of Analysis	Mar 15, 2023	T102393
D2318591	Certificate of Analysis	Mar 15, 2023	T102393
E1528141	Certificate of Analysis	Feb 07, 2023	T102393

Solubility	Soluble in DMSO (5 mg/ml), and water (210 mg/L).
Sensitivity	Light sensitive
Molecular Weight	228.300 g/mol
XLogP3	-0.600
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	1
Exact Mass	228.003 Da
Monoisotopic Mass	228.003 Da
Topological Polar Surface Area	100.000 Å²
Heavy Atom Count	14
Formal Charge	0
Complexity	387.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1