Trifluoperazine 2HCl - 10mM in DMSO , Serotonin 2c (5-HT2c) receptor antagonist, CAS No.440-17-5, Serotonin 2c (5-HT2c) receptor antagonist

CAS: 440-17-5 Cat. No.: T408235 Fórmula: C₂₁H₂₄F₃N₃S·2HCl Peso molecular: 480.42 Beilstein Registry Number: 3820020 Número EC: 207-123-0 PubChem CID: 66064

CALIDAD & PUREZA 10mM in DMSO

Synonyms

SKF5019 | 10H-Phenothiazine, 10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoromethyl)-, hydrochloride (1:2)

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Information

Trifluoperazine (SKF5019) is adopamine D2receptor inhibitor withIC50of 1.1 nM.
In vitro

Trifluoperazine binds to α1A- and α1B-adrenoceptor with Ki value of 27.6 nM and 19.2 nM, respectively, with α1B/α1A ratio of 0.7. Trifluoperazine inhibits Mycobacterium tuberculosis (Mtb) with MICs of 7.6 μg/mL. Trifluoperazine (< 14.78 mM) suppresses the activities of the mouse splenic NK cell cytotoxicity and the effector-target cell conjugation in a dose dependent manner. Trifluoperazine suppresses interferon-alpha or interleukin-2 induced augmentation of the cytolytic activity of NK cells. Trifluoperazine inhibits the gene expression of voltage-dependent potassium channel Kv2.1 from human brain (hKv2.1).

In vivo

Trifluoperazine dose dependently decreases avoidance responses and increases response failures in rats where behavior is maintained under a discrete-trial avoidance.
Cell Data

cell lines：pancreatic cancer cell line BxPc3-RFP

Concentrations：

Incubation Time：

Powder Purity:≥99%

Especificaciones

Sinónimos

SKF5019 | 10H-Phenothiazine, 10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoromethyl)-, hydrochloride (1:2)

Especificaciones y pureza

10mM in DMSO

Mecanismos bioquímicos y fisiológicos

Trifluoperazine (SKF5019) is a dopamine D2 receptor inhibitor with IC50 of 1.1 nM.

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Tipo de acción

ANTAGONIST

Mecanismo de acción

Serotonin 2c (5-HT2c) receptor antagonist

Nombres e identificadores

Isómeros SMILES

CN1CCN(CC1)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)C(F)(F)F.Cl.Cl

WGK Alemania

3

RTECS

SP1750000

PubChem CID

66064

Peso molecular

480.42

Beilstein

3820020

Reaxy-Rn

3820024

Propiedades químicas y físicas

• Solubilidad: Solubility (25°C) In vitro DMSO: 35 mg/mL (201.02 mM); Water: 35 mg/mL (201.02 mM); Ethanol: 35 mg/mL
• Punto de fusión (°C): 243°C

Preguntas frecuentes

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 440-17-5, the molecular formula is C21H24F3N3S·2HCl, and the molecular weight is 480.42 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.