Tyrene CR4 , Tyrosine-protein kinase JAK2 inhibitor, CAS No.1110670-40-0, Tyrosine-protein kinase JAK2 inhibitor

CAS: 1110670-40-0 Cat. No.: T335809 Fórmula: C₁₉H₁₆N₂O₃ Peso molecular: 320.34 PubChem CID: 9861871

Synonyms

UNII-T669M1395I | 1110670-40-0 | J-002517 | N-benzyl-2-cyano-5-(3,4-dihydroxyphenyl)penta-2,4-dienamide | Q27289723 | (2E,4E)-N-benzyl-2-cyano-5-(3,4-dihydroxyphenyl)penta-2,4-dienamide | LS-104 | (E,E)-2-(Benzylaminocarbonyl)-3-(3,4-dihydroxystyryl)acryl

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Descripción general

Tyrene CR4 is a cell-permeable, reversible, and substrate competitive hydroxystryrylacrylonitrile tyrosine kinase inhibitor that show anti-tumor properties. Tyrene CR4 potently inhibits JAK2 and Bcr-Abl (the fusion protein of Bcr and c-Abl) (IC|50|~100-600 nM and 500-700 nM, respectively) by targeting their kinase activities. Tyrene CR4 displays excellent selectivity over other tyrosine kinases, Btk, Lck, Lyn, Src, Syk and ZAP-70 (IC|50|>5 μM). Tyrene CR4 has been shown to preferentially induce apoptosis in acute lymphoblastic (ALL) and myeloid leukemia cells (AML), while exhibiting little deleterious effect towards normal bone marrow cell differentiation and proliferation. Tyrene CR4 has also been reported to be more potent than AG 490 in inducing ALL cells growth arrest (IC|50|~ 120 nM vs. 5-25 μM).

Specifications

Sinónimos

UNII-T669M1395I | 1110670-40-0 | J-002517 | N-benzyl-2-cyano-5-(3,4-dihydroxyphenyl)penta-2,4-dienamide | Q27289723 | (2E,4E)-N-benzyl-2-cyano-5-(3,4-dihydroxyphenyl)penta-2,4-dienamide | LS-104 | (E,E)-2-(Benzylaminocarbonyl)-3-(3,4-dihydroxystyryl)acryl

Condiciones de almacenamiento de almacenamiento

Store at -20°C

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Tipo de acción

INHIBITOR

Mecanismo de acción

Tyrosine-protein kinase JAK2 inhibitor

Nombres e identificadores

Sonrisas canónicas

C1=CC=C(C=C1)CNC(=O)C(=CC=CC2=CC(=C(C=C2)O)O)C#N

Isómeros SMILES

C1=CC=C(C=C1)CNC(=O)/C(=C/C=C/C2=CC(=C(C=C2)O)O)/C#N

PubChem CID

9861871

Peso molecular

320.34

Propiedades químicas y físicas

• Solubilidad: DMSO (10 mg/ml)
• Peso molecular: 320.300 g/mol
• XLogP3: 3.100
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 320.116 Da
• Monoisotopic Mass: 320.116 Da
• Topological Polar Surface Area: 93.400 Ų
• Heavy Atom Count: 24
• Formal Charge: 0
• Complexity: 526.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 2
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 2
• Covalently-Bonded Unit Count: 1

Preguntas frecuentes

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1110670-40-0, the molecular formula is C19H16N2O3, and the molecular weight is 320.34 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.