Urolithin A - Moligand™, ≥98%(HPLC) , CAS No.1143-70-0

CAS: 1143-70-0 Cat. No.: U287598 Fórmula: C13H8O4 Peso molecular: 228.20 Número EC: 881-478-5 PubChem CID: 5488186
Disponible para pedir
GRADE & PURITY Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%(HPLC)
Synonyms
3,8-Dihydroxyurolithin | 3,8-dihydroxy-urolithin | FT-0778244 | 3,8-dihydroxy-6h-dibenzo[b,d]pyran-6-one | 3,8-Dihydroxy-6H-dibenzo(b,d)pyran-6-one | CHEBI:168442 | 6H-Dibenzo[b,d]pyran-6-one, 3,8-dihydroxy- | A901528 | AC-31959 | ILJ8NEF6DT | SY070232 |
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
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Size
Alemania (EU)
USA*
Price
Qty
10mg
U287598-10mg
—
3 Disponible
8,59€
100mg
U287598-100mg
—
3 Disponible
9,46€
250mg
U287598-250mg
—
3 Disponible
10,33€
1g
U287598-1g
—
1 Disponible
12,06€
5g
U287598-5g
—
3 Disponible
34,62€
25g
U287598-25g
—
2 Disponible
121,40€
Enter a quantity for the sizes you want to add.
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Why this grade

Moligand™, ≥98%(HPLC) Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 11 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Specifications

Sinónimos
3,8-Dihydroxyurolithin | 3,8-dihydroxy-urolithin | FT-0778244 | 3,8-dihydroxy-6h-dibenzo[b,d]pyran-6-one | 3,8-Dihydroxy-6H-dibenzo(b,d)pyran-6-one | CHEBI:168442 | 6H-Dibenzo[b,d]pyran-6-one, 3,8-dihydroxy- | A901528 | AC-31959 | ILJ8NEF6DT | SY070232 |
Especificaciones y pureza
Moligand™, ≥98%(HPLC)
Mecanismos bioquímicos y fisiológicos
PI 3-K/Akt/mTOR signaling pathway inhibitor; blocks phosphorylation of Akt and p70S6K in pancreatic ductal adenocarcinoma (PDAC). Inhibits proliferation and migration and promotes apoptosis of PDAC cell linesin vitro(IC50values are 10.23 - 62.28 μM). Supp
Condiciones de almacenamiento de almacenamiento
Store at -20°C
Enviado en
Ice chest + Ice pads
Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.
Grado
Moligand™
Pureza
≥98%(HPLC)
Nombres e identificadores
Pubchem Sid504763884
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/504763884
Sonrisas canónicasC1=CC2=C(C=C1O)C(=O)OC3=C2C=CC(=C3)O
IUPAC Name3,8-dihydroxybenzo[c]chromen-6-one
InChIKeyRIUPLDUFZCXCHM-UHFFFAOYSA-N
INCHI1S/C13H8O4/c14-7-1-3-9-10-4-2-8(15)6-12(10)17-13(16)11(9)5-7/h1-6,14-15H
Isómeros SMILES C1=CC2=C(C=C1O)C(=O)OC3=C2C=CC(=C3)O
PubChem CID 5488186
Peso molecular 228.20

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassPhenylpropanoids and polyketides
ClaseCoumarins and derivatives
SubclassNot available
Intermediate Tree Nodes Not available
Direct ParentCoumarins and derivatives
Alternative Parents Isocoumarins and derivatives  2-benzopyrans  1-benzopyrans  Pyranones and derivatives  1-hydroxy-2-unsubstituted benzenoids  Heteroaromatic compounds  Lactones  Oxacyclic compounds  Organooxygen compounds  Organic oxides  Hydrocarbon derivatives  
Molecular FrameworkAromatic heteropolycyclic compounds
Substituents Coumarin - Isocoumarin - Benzopyran - 1-benzopyran - 2-benzopyran - 1-hydroxy-2-unsubstituted benzenoid - Pyranone - Pyran - Benzenoid - Heteroaromatic compound - Lactone - Oxacycle - Organoheterocyclic compound - Organooxygen compound - Hydrocarbon derivative - Organic oxide - Organic oxygen compound - Aromatic heteropolycyclic compound
DescripciónThis compound belongs to the class of organic compounds known as coumarins and derivatives. These are polycyclic aromatic compounds containing a 1-benzopyran moiety with a ketone group at the C2 carbon atom (1-benzopyran-2-one).
External Descriptors Not available
Estructura 3D
Modelo de Estructura Química Interactiva





Objetivos asociados (no humanos)
Escherichia coli (133304 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mus musculus (284745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasma (328 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mecanismos de acción
Certificados (CoA, COO, BSE/TSE y tabla de análisis)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

31 results found

Lot NumberCertificate TypeFechaArticulo
A2612617Certificate of AnalysisDec 31, 2025 U287598
A2612618Certificate of AnalysisDec 31, 2025 U287598
A2612619Certificate of AnalysisDec 31, 2025 U287598
A2612620Certificate of AnalysisDec 31, 2025 U287598
A2612621Certificate of AnalysisDec 31, 2025 U287598
F2617092Certificate of AnalysisDec 31, 2025 U287598
J2228751Certificate of AnalysisAug 11, 2025 U287598
J2228750Certificate of AnalysisAug 11, 2025 U287598
J2228749Certificate of AnalysisAug 11, 2025 U287598
J2228744Certificate of AnalysisAug 11, 2025 U287598
J2228742Certificate of AnalysisAug 11, 2025 U287598
J2228740Certificate of AnalysisAug 11, 2025 U287598
L2505049Certificate of AnalysisJan 13, 2025 U287598
A2522267Certificate of AnalysisJan 13, 2025 U287598
K2517243Certificate of AnalysisJan 13, 2025 U287598
J2511017Certificate of AnalysisJan 13, 2025 U287598
I2525065Certificate of AnalysisJan 13, 2025 U287598
B2507237Certificate of AnalysisJan 13, 2025 U287598
A2522274Certificate of AnalysisJan 13, 2025 U287598
A2522272Certificate of AnalysisJan 13, 2025 U287598
A2522269Certificate of AnalysisJan 13, 2025 U287598
E2422127Certificate of AnalysisOct 19, 2022 U287598
J2228745Certificate of AnalysisOct 19, 2022 U287598
D2422069Certificate of AnalysisOct 19, 2022 U287598
C2427088Certificate of AnalysisOct 19, 2022 U287598
J2330076Certificate of AnalysisOct 19, 2022 U287598
J2412034Certificate of AnalysisOct 19, 2022 U287598
J2429067Certificate of AnalysisOct 19, 2022 U287598
L2416372Certificate of AnalysisOct 19, 2022 U287598
F2215111Certificate of AnalysisJun 21, 2022 U287598
F2220042Certificate of AnalysisJun 20, 2022 U287598

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Propiedades químicas y físicas
SolubilidadSolvent:DMSO, Max Conc. mg/mL: 22.82, Max Conc. mM: 100
Sensibilidadheat sensitive
Peso molecular228.200 g/mol
XLogP32.300
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count0
Exact Mass228.042 Da
Monoisotopic Mass228.042 Da
Topological Polar Surface Area66.800 Ų
Heavy Atom Count17
Formal Charge0
Complexity317.000
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
Citations of This Product
Referencias
1. Yang Yang, Pui-Kei Lee, Ho-Ching Wong, Danyue Zhao.  (2023)  Oral supplementation of Gordonibacter urolithinfaciens promotes ellagic acid metabolism and urolithin bioavailability in mice.  FOOD CHEMISTRY,      [PMID:37976786] [10.1016/j.foodchem.2023.137953]
2. Zeyuan Jin, Yaqi Zhang, Haijun Hu, Qian Li, Liwen Zhang, Kefei Zhao, Wenxing Liu, Lanjuan Li, Changyou Gao.  (2024)  Closed-Loop Theranostic Microgels for Immune Microenvironment Modulation and Microbiota Remodeling in Ulcerative Colitis.  BIOMATERIALS,      [PMID:39288617] [10.1016/j.biomaterials.2024.122834]
3. Huang Zhengyuan, Ren Zhongyu, Wang Sanwang, Xiao Ling, Ling Yipeng, Xie Yinping, Wang Gaohua, Zhou Benhong.  (2025)  Urolithin A alleviates schizophrenic-like behaviors and cognitive impairment in rats through modulation of neuroinflammation, neurogenesis, and synaptic plasticity.  Scientific Reports,  15  (1): (1-15).  [PMID:40140679] [10.1038/s41598-025-93554-9]
4. Zhengyuan Huang, Guanghui Chen, Zhongyu Ren, Ling Xiao, Ziyue Chen, Yinping Xie, Gaohua Wang, Benhong Zhou.  (2025)  Urolithin A ameliorates schizophrenia-like behaviors and cognitive impairments in female rats by modulating NLRP3 signaling.  INTERNATIONAL IMMUNOPHARMACOLOGY,      [PMID:39987632] [10.1016/j.intimp.2025.114336]
5. Yang Yang, Ke Wang, Jia-Chi Chiou, Danyue Zhao.  (2025)  Metabolomic insights into the prebiotic and metabolic regulatory properties of ellagic acid and urolithins on probiotic-like bacteria in vitro.  Current Research in Microbial Sciences,      [PMID:40672532] [10.1016/j.crmicr.2025.100425]
6. Weikang Sun, Renjie Luo, Qingwei Qu, Jie Yang, Guang Yang, Lihua Song, Peng Cao, Erguang Li.  (2025)  Ellagic Acid and the Metabolite Urolithin A Suppress HSV-1 Infection and Brain Inflammation by Targeting Casein Kinase CK2.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,      [PMID:40560040] [10.1021/acs.jafc.5c04281]
7. Xiaoyi Sun, Chunlin Gao, Pei Zhang, Yingchao Peng, Meiqiu Wang, Jiuyu Liu, Chenxi Ma, Shan Li, Zhengkun Xia.  (2025)  Urolithin A protects against calcium oxalate-induced crystal formation and kidney injury by regulating PCK1 to restore mitophagy function in kidney stone disease.  BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE,  1872  (3): (168106).  [PMID:41265017] [10.1016/j.bbadis.2025.168106]
8. Huimin Li, Jingya Ruan, Jiayan Huang, Yijin Wu, Jiaming Cheng, Ongher Kouye, Yi Zhang, Tao Wang.  (2025)  Pomegranate peel and ellagic acid attenuate ulcerative colitis by targeting AKR1B1/B3 to inhibit NLRP3.  PHYTOMEDICINE,      [PMID:41308394] [10.1016/j.phymed.2025.157587]
9. Jiayu Chen, Hairong Zhao, Yuemei Xi, Shanpan Fu, De Xie, Linqian Yu, Qiang Wang, Binyang Chen, Qian Zhang, Mingyan Zhang, Xueling Ye, Mengni Wu, Wanling Que, Shuyi Chen, Yayan Liu, Tetsuya Yamamoto, Hidenori Koyama, Hong Zhao, Jidong Cheng.  (2025)  Activation of mitophagy antagonizes high uric acid-induced hepatic lipid accumulation.  JOURNAL OF BIOLOGICAL CHEMISTRY,      [PMID:41391771] [10.1016/j.jbc.2025.111054]
10. Miao Chen, Manzhen Li, Yunqian Lu, Ziqi Liu, Dengxue Yang, Yaoyao Guo, Xiangtao Wang.  (2026)  Mitochondria-targeting urolithin A/borneol nanoparticles: enhanced therapeutic effects for cerebral ischemia–reperfusion injury in rats.  INTERNATIONAL JOURNAL OF PHARMACEUTICS,      [PMID:41740767] [10.1016/j.ijpharm.2026.126717]
11. Jiaqi Xiao, Lihua Qu, Xuan Qin, Chao Chen, Yuan Xu, Xinyu Que, Yaoyao Ma, Wentao Huang, Haoxiang Ou, Chao Wu, Yongfen Bao, Shigang Shan.  (2026)  Urolithin A Attenuates Aging-Induced Liver Injury by Inhibiting Nur77 Ubiquitination and Degradation.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,      [PMID:] [10.1021/acs.jafc.5c17898]
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Preguntas frecuentes

What is Moligand??
Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.
How should this product be stored?
Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.
How is this product shipped?
This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.
What are the CAS number, molecular formula and molecular weight?
The CAS Number is 1143-70-0, the molecular formula is C13H8O4, and the molecular weight is 228.20 g/mol. InChIKey RIUPLDUFZCXCHM-UHFFFAOYSA-N.
What documentation is provided?
Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.

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