Vaborbactam - Moligand™, 10mM in Water , Carbepenem-hydrolyzing beta-lactamase KPC inhibitor, CAS No.1360457-46-0, Carbepenem-hydrolyzing beta-lactamase KPC inhibitor

CAS: 1360457-46-0 Cat. No.: V655112 Fórmula: C₁₂H₁₆BNO₅S Peso molecular: 297.14 Número EC: 807-463-5

GRADE & PURITY Moligand™, 10mM in Water

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Vaborbactam (RPX7009) is a cyclic boronic acid pharmacophore β-lactamase inhibitor.

In Vitro

Vaborbactam is a broad spectrum of inhibition of β-lactamases, with particularly potent activity against KPC, CTX-M, SHV, and CMY enzymes. Vaborbactam restores SM 7338 activity for 72.7 to 98.1% of CPE isolates at ≤2 μg/mL, and maximum potentiation is achieved with fixed concentrations of ≥8 μg/mL of the inhibitor (≥96.5% of isolates are inhibited at ≤2 μg/mL of SM 7338-vaborbactam). SM 7338-vaborbactam with a fixed concentration of 8 μg/mL of the inhibitor (MIC50, ≤0.06 μg/mL for all organisms) inhibits 93.7% of the CPE isolates displaying elevated SM 7338 MICs at ≤1 μg/mL. By forming a reversible dative bond with the blactamase, vaborbactam acts as a competitive inhibitor and is not hydrolyzed by the b-lactamase. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Vaborbactam is well tolerated and has a half-life of 1.23 h, and steadystate volume of distribution of 21.0 L in subjects. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Specifications

Especificaciones y pureza

Moligand™, 10mM in Water

Mecanismos bioquímicos y fisiológicos

Vaborbactam (RPX7009) is a cyclic boronic acid pharmacophore β-lactamase inhibitor.

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

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Grado

Moligand™

Tipo de acción

INHIBITOR

Mecanismo de acción

Carbepenem-hydrolyzing beta-lactamase KPC inhibitor

Nombres e identificadores

• Isómeros SMILES: B1([C@H](CC[C@H](O1)CC(=O)O)NC(=O)CC2=CC=CS2)O
• CAS alternativo: 1360457-46-0,1575712-03-6
• Términos de entrada MeSH: vaborbactam
• Peso molecular: 297.14

Preguntas frecuentes

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1360457-46-0, the molecular formula is C12H16BNO5S, and the molecular weight is 297.14 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.