Moligand™, 10 mM in DMSO Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Protected from light,Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 33 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Verapamil ((±)-Verapamil) is a calcium channel blocker and a potent and orally active first-generation P-glycoprotein (P-gp) inhibitor. Verapamil also inhibits CYP3A4 . Verapamil has the potential for high blood pressure, heart arrhythmias and angina research.
| Isómeros SMILES | CC(C)C(CCCN(C)CCC1=CC(=C(C=C1)OC)OC)(C#N)C2=CC(=C(C=C2)OC)OC |
|---|---|
| Número ONU | UN 2811 |
| Grupo de embalaje | III |
| Peso molecular | 454.6 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →| Punto de ebullición (°C) | 243-246 ºC |
|---|---|
| Punto de fusión (°C) | 25°C |
| 1. Jie Gao, Haji A. Aisa. (2017) Terpenoids from Euphorbia soongarica and Their Multidrug Resistance Reversal Activity. JOURNAL OF NATURAL PRODUCTS, [PMID:28590124] [10.1021/acs.jnatprod.6b01099] |
| 2. Jie Huang, Xiao Tang, Ziqiong Yang, Jianqiu Chen, Kun Wang, Chengnan Shi, Zihan Liu, Ming Wu, Qian Du. (2023) Enhancing oral delivery and anticancer efficacy of 7-ethyl-10-hydroxycamptothecin through self-assembled micelles of deoxycholic acid grafted N'-nonyl-trimethyl chitosan. COLLOIDS AND SURFACES B-BIOINTERFACES, [PMID:38215603] [10.1016/j.colsurfb.2023.113736] |
| 3. Yu Wang, Yao Yu, Yi-Ping Hou, Xue-Wei Mao, Zong-Liang Liu, Jian Cui, Bi Wang, Shu Xu, Yi-Yun Qian, Yan-Qin Jiang, Min Wei, Ping-Ping Song. (2023) Crucial Role of the Ca2+/CN Signaling Pathway in the Antifungal Activity of Seselin against Botrytis cinerea. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, [PMID:37313981] [10.1021/acs.jafc.3c01474] |
| 4. Lan Tang, Kaijuan Huang, Wenhui Jiang, Lulu Fu, Ran Zhang, Liting Shen, Zhimin Ou, Ye Huang, Zhenhai Zhang. (2023) Exploration of the inhibition action of TPGS on tumor cells and its combined use with chemotherapy drugs. DRUG DELIVERY, [PMID:36852689] [10.1080/10717544.2023.2183830] |
| 5. Bin Jiao, Huimin Ye, Xinwei Liu, Jiexun Bu, Junhan Wu, Wenpeng Zhang, Yunfeng Zhang, Zheng Ouyang. (2021) Handheld Mass Spectrometer with Intelligent Adaptability for On-Site and Point-of-Care Analysis. ANALYTICAL CHEMISTRY, [PMID:34780167] [10.1021/acs.analchem.1c02508] |
| 6. Yuqin Zhou, Weitong Hu, Xiangli Zhang, Yi Wang, Wenya Zhuang, Fengzhi Li, Qingyong Li. (2021) Cellular Uptake and Transport Characteristics of FL118 Derivatives in Caco-2 Cell Monolayers. CHEMICAL & PHARMACEUTICAL BULLETIN, 69 (11): (1054-1060). [PMID:34719586] [10.1248/cpb.c21-00467] |
| 7. Xiaoyu Lu, Hangyi Wu, Yiping Liang, Zhenhai Zhang, HuiXia Lv. (2021) Redox-responsive prodrug for improving oral bioavailability of paclitaxel through bile acid transporter-mediated pathway. INTERNATIONAL JOURNAL OF PHARMACEUTICS, [PMID:33746013] [10.1016/j.ijpharm.2021.120496] |
| 8. Li Sinai, Liu Hongxu, Li Yue, Qin Xiaomei, Li Mengjie, Shang Juju, Xing Wenlong, Gong Yanbing, Liu Weihong, Zhou Mingxue. (2021) Shen-Yuan-Dan Capsule Attenuates Verapamil-Induced Zebrafish Heart Failure and Exerts Antiapoptotic and Anti-Inflammatory Effects via Reactive Oxygen Species–Induced NF-κB Pathway. Frontiers in Pharmacology, [PMID:33732158] [10.3389/fphar.2021.626515] |
| 9. Songhui Zhou, Ruicheng Wang, Hong Xiao. (2020) Adipocytes induce the resistance of ovarian cancer to carboplatin through ANGPTL4. ONCOLOGY REPORTS, 44 (3): (927-938). [PMID:32705217] [10.3892/or.2020.7647] |
| 10. Renjie Xu, Hongdan Zhu, Lingmin Hu, Beimeng Yu, Xiaohua Zhan, Yichu Yuan, Ping Zhou. (2020) Characterization of the intestinal absorption of morroniside from Cornus officinalis Sieb. et Zucc via a Caco-2 cell monolayer model. PLoS One, 15 (5): (e0227844). [PMID:32470043] [10.1371/journal.pone.0227844] |
| 11. Zhao Li, Tingwei Cai, Yao Qin, Yunhua Zhang, Ruoheng Jin, Kaikai Mao, Xun Liao, Hu Wan, Jianhong Li. (2020) Transcriptional Response of ATP-Binding Cassette (ABC) Transporters to Insecticide in the Brown Planthopper, Nilaparvata lugens (Stål). Insects, 11 (5): (280). [PMID:32370222] [10.3390/insects11050280] |
| 12. Can Wu, Nani Wang, Pingcui Xu, Xuping Wang, Dan Shou, Yan Zhu. (2020) Preparation and application of polyvinyl alcohol-decorated cell membrane chromatography for screening anti-osteoporosis components from Liuwei Dihuang decoction-containing serum. JOURNAL OF SEPARATION SCIENCE, 43 (11): (2105-2114). [PMID:32135026] [10.1002/jssc.201901203] |
| 13. Yonghong Miao, Xiaoxue Sun, Guojun Gao, Xianglei Jia, Hao Wu, Ying Chen, Liyong Huang. (2019) Evaluation of (-)-epigallocatechin-3-gallate (EGCG)-induced cytotoxicity on astrocytes: A potential mechanism of calcium overloading-induced mitochondrial dysfunction. TOXICOLOGY IN VITRO, [PMID:31356857] [10.1016/j.tiv.2019.104592] |
| 14. Weng Qi, Zhou Leilei, Xia Lihua, Zheng Yixin, Zhang Xiangli, Li Fengzhi, Li Qingyong. (2019) In vitro evaluation of FL118 and 9-Q20 cytotoxicity and cellular uptake in 2D and 3D different cell models. CANCER CHEMOTHERAPY AND PHARMACOLOGY, 84 (3): (527-537). [PMID:31030236] [10.1007/s00280-019-03846-x] |
| 15. Renjie Xu, Yichu Yuan, Jia Qi, Jia Zhou, Xiaowen Guo, Jian Zhang, Ruanjuan Zhan. (2018) Elucidation of the Intestinal Absorption Mechanism of Loganin in the Human Intestinal Caco-2 Cell Model. Evidence-based Complementary and Alternative Medicine, [PMID:30671130] [10.1155/2018/8340563] |
| 16. Ying Chen, Jianjun Chen, Xiaoxue Sun, Xiaoxiao Shi, Lei Wang, Liyong Huang, Wenke Zhou. (2018) Evaluation of the neuroprotective effect of EGCG: a potential mechanism of mitochondrial dysfunction and mitochondrial dynamics after subarachnoid hemorrhage. Food & Function, 9 (12): (6349-6359). [PMID:30452052] [10.1039/C8FO01497C] |
| 17. Xu Renjie, Peng Ying, Wang Mengyue, Li Xiaobo. (2018) Intestinal Absorption of Isoalantolactone and Alantolactone, Two Sesquiterpene Lactones from Radix Inulae, Using Caco-2 Cells. EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS, 44 (2): (295-303). [PMID:30209793] [10.1007/s13318-018-0510-x] |
| 18. Nani Wang, Qiaoyan Zhang, Hailiang Xin, Dan Shou, Luping Qin. (2017) Osteoblast cell membrane chromatography coupled with liquid chromatography and time-of-flight mass spectrometry for screening specific active components from traditional Chinese medicines. JOURNAL OF SEPARATION SCIENCE, 40 (22): (4311-4319). [PMID:28884956] [10.1002/jssc.201700688] |
| 19. Yixian Liu, Bingjie Liu, Yan Zhang, Youmei Peng, Chenzheng Huang, Ning Wang, Jinhua Jiang, Qingduan Wang, Junbiao Chang. (2017) Intestinal absorption mechanisms of 2′-deoxy-2′-β-fluoro-4′-azidocytidine, a cytidine analog for AIDS treatment, and its interaction with P-glycoprotein, multidrug resistance-associated protein 2 and breast cancer resistance protein. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, [PMID:28487144] [10.1016/j.ejps.2017.05.009] |
| 20. Chen Ying, Huang Liyong, Zhang Huiyong, Diao Xiling, Zhao Shuyang, Zhou Wenke. (2016) Reduction in Autophagy by (-)-Epigallocatechin-3-Gallate (EGCG): a Potential Mechanism of Prevention of Mitochondrial Dysfunction After Subarachnoid Hemorrhage. MOLECULAR NEUROBIOLOGY, 54 (1): (392-405). [PMID:26742518] [10.1007/s12035-015-9629-9] |
| 21. Qing Wang, Yao Long, Lin Yao, Li Xu, Zhi-Guo Shi, Lanying Xu. (2015) Preparation, characterization and application of a reversed phase liquid chromatography/hydrophilic interaction chromatography mixed-mode C18-DTT stationary phase. TALANTA, [PMID:26695288] [10.1016/j.talanta.2015.09.009] |
| 22. Qing Wang, Zhi-Yuan Luo, Mao Ye, Yu-Zhuo Wang, Li Xu, Zhi-guo Shi, Lanying Xu. (2015) Preparation, chromatographic evaluation and application of adenosine 5′-monophosphate modified ZrO2/SiO2 stationary phase in hydrophilic interaction chromatography. JOURNAL OF CHROMATOGRAPHY A, [PMID:25627970] [10.1016/j.chroma.2015.01.017] |
| 23. Wenjing Li, Xinru Li, Yajie Gao, Yanxia Zhou, Shujin Ma, Yong Zhao, Jinwen Li, Yan Liu, Xinglin Wang, Dongdong Yin. (2013) Inhibition Mechanism of P-glycoprotein Mediated Efflux by mPEG-PLA and Influence of PLA Chain Length on P-glycoprotein Inhibition Activity. MOLECULAR PHARMACEUTICS, [PMID:24256068] [10.1021/mp4004223] |
| 24. Weiguo Song, Hekai Yang, Ying Wang, Shuzhen Chen, Wenda Zhong, Qian Wang, Wenshuo Ding, Guangzhao Xu, Chen Meng, Ying Liang, Zhe-Sheng Chen, Shuhua Cao, Liuya Wei, Fahui Li. (2024) Glutathione-Sensitive Photosensitizer–Drug Conjugates Target the Mitochondria to Overcome Multi-Drug Resistance in Cancer. Advanced Science, [PMID:38898730] [10.1002/advs.202307765] |
| 25. Wang Aiping, Ning Jie, Zhao Lu, Xu Renjie. (2024) Lipid-lowering effect and oral transport characteristics study of curculigoside. Frontiers in Cardiovascular Medicine, [PMID:39015683] [10.3389/fcvm.2024.1426379] |
| 26. Hairong Chen, Guichun Wang, Xiaoliang Li, Jingjing Wang, Xinrui Wang, Yuxiao Wang, Zhenzhen Liu, Jiajia Liu, Yang Ding, Jian Guo, Shuangying Gui. (2024) Multi-functional D-alpha-tocopheryl polyethylene glycol succinate surface modified nanocrystals improve the stability and oral bioavailability of pueraria flavonoids. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, [PMID:] [10.1016/j.jddst.2024.105623] |
| 27. Lu Yang, Zijin Lin, Ruijing Mu, Wenhan Wu, Hao Zhi, Xiaodong Liu, Hanyu Yang, Li Liu. (2024) Neurons enhance blood–brain barrier function via upregulating claudin-5 and VE-cadherin expression due to glial cell line-derived neurotrophic factor secretion. eLife, [PMID:39475379] [10.7554/eLife.96161] |
| 28. Rui Li, Wenhui Ruan, Rui Hao, Jue Chen, Chu Xu, Liyan Lu, Yingli Wang. (2025) O-carboxymethyl chitosan-grafted-cholesterol succinic acid monoester nanomicelles improve oral absorption of cannabidiol: Preparation, intestinal absorption in vitro, and pharmacokinetics in vivo. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, [PMID:] [10.1016/j.jddst.2025.106763] |
| 29. Liangxing Tu, Ping Han, Yongbing Sun, Yi Jin, Kaili Hu, Meng Cheng, Yisen Shao, Jianfang Feng, Fangying Yuan. (2024) Study on the preparation of stabilizer-free silymarin nanocrystals and its oral absorption mechanisms. International Journal of Pharmaceutics-X, [PMID:39498271] [10.1016/j.ijpx.2024.100292] |
| 30. Yao Yu, Xinru Li, Yiping Hou, Min Wei, Yiyun Qian, Yuxin Zhou, Min Yin, Yanqin Jiang, Pingping Song. (2024) The effect of Ca2+-calcineurin signaling pathway on the antifungal activity of Pd-D-V against Botrytis cinerea. PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, [PMID:39084802] [10.1016/j.pestbp.2024.106007] |
| 31. Lin Qing, Ling Li-qin, Guo Ling, Gong Tao, Sun Xun, Zhang Zhi-rong. (2015) Intestinal absorption characteristics of imperialine: in vitro and in situ assessments. ACTA PHARMACOLOGICA SINICA, 36 (7): (863-873). [PMID:26051111] [10.1038/aps.2015.27] |
| 32. Liyun Ma, Simin Liu, Qing Wang, Lin Yao, Li Xu. (2015) Cucurbit(6)uril immobilized on silica: A novel high-performance liquid chromatographic stationary phase. JOURNAL OF SEPARATION SCIENCE, 38 (7): (1082-1089). [PMID:25641573] [10.1002/jssc.201401049] |
| 33. Qing Wang, Yao Long, Lin Yao, Mao Ye, Li Xu. (2017) C18-COOH Silica: Preparation, Characterisation and Its Application in Purification of Quaternary Ammonium Alkaloids from Coptis chinensis. PHYTOCHEMICAL ANALYSIS, 28 (4): (332-343). [PMID:28198057] [10.1002/pca.2680] |
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