VH 032, phenol - ≥98%(HPLC) , CAS No.2244684-42-0

CAS: 2244684-42-0 Cat. No.: V288384 Molecular Weight: 488.6 PubChem CID: 142452655

GRADE & PURITY ≥98%(HPLC)

Synonyms

(2S,4R)-1-((S)-2-acetamido-3,3-dimethylbutanoyl)-4-hydroxy-N-(2-hydroxy-4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide | VH032-OH | (2S,4R)-1-((S)-2-Acetamido-3,3-dimethylbutanoyl)-4-hydroxy-N-[2-hydroxy-4-(4-methylthiazywol-5-yl)benzyl]pyrrolid

Storage

Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Application

PROTAC

Overview

Product description

VH032-OH is the VH032-based VHL ligand. VH032-OH can be connected to the ligand for protein by a linker to form PROTACs

Product application

VH032-OH is a functionalized von-Hippel-Lindau (VHL) ligand with a terminal hydroxyl group. Allows rapid conjugation with many linkers containing active leaving groups. A basic building block for development of a protein degrader library.

Specifications

Synonyms

(2S, 4R)-1-((S)-2-acetamido-3, 3-dimethylbutanoyl)-4-hydroxy-N-(2-hydroxy-4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide | VH032-OH | (2S, 4R)-1-((S)-2-Acetamido-3, 3-dimethylbutanoyl)-4-hydroxy-N-[2-hydroxy-4-(4-methylthiazywol-5-yl)benzyl]pyrrolid

Specifications & Purity

≥98%(HPLC)

Biochemical and Physiological Mechanisms

Functional von Hippel Lindau protein ligand (VHL) for research and development; It integrates E3 ligase ligands with terminal hydroxyl groups, which can bind to target protein ligands.

Storage

Store at -20°C, Argon charged

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥98%(HPLC)

Names and Identifiers

• Pubchem Sid: 528767632
• Canonical Smiles: CC1=C(SC=N1)C2=CC(=C(C=C2)CNC(=O)C3CC(CN3C(=O)C(C(C)(C)C)NC(=O)C)O)O
• IUPAC Name: (2S,4R)-1-[(2S)-2-acetamido-3,3-dimethylbutanoyl]-4-hydroxy-N-[[2-hydroxy-4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide
• InChIKey: CUHVZPHLQIBKHX-LVCYWYKZSA-N
• INCHI: 1S/C24H32N4O5S/c1-13-20(34-12-26-13)15-6-7-16(19(31)8-15)10-25-22(32)18-9-17(30)11-28(18)23(33)21(24(3,4)5)27-14(2)29/h6-8,12,17-18,21,30-31H,9-11H2,1-5H3,(H,25,32)(H,27,29)/t17-,18+,21-/m1/s1
• PubChem CID: 142452655
• Molecular Weight: 488.6

Chemical and Physical Properties

• Solubility: Solvent:DMSO, Max Conc. mg/mL: 48.86, Max Conc. mM: 100; Solvent:DMF, Max Conc. mg/mL: 48.86, Max Conc. mM: 100
• Sensitivity: heat sensitive