Vimirogant hydrochloride - ≥98% , CAS No.V659033

CAS: V659033 Cat. No.: V659033

GRADE & PURITY ≥98%

Storage

Store at 2-8°C,Desiccated

Shipped In

Wet ice

Overview

Vimirogant (VTP-43742) hydrochloride is a potent, selective, and orally active RORγt inhibitor ( K i =3.5 nM; IC 50 =17 nM). Vimirogant hydrochloride exhibits >1000-fold selectivity versus the RORα and RORβ isotypes. Vimirogant hydrochloride inhibits Th17

Appearance:Solid

IC50& Target:RORγt 3.5 nM (Ki) RORγt 17 nM (IC 50 )

In Vitro:Vimirogant hydrochloride inhibits the secretion of IL-17A from activated hPBMCs (IC 50 =18 nM) and human whole blood (IC 50 =192 nM). MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo:In the MOG35-55/CFA immunized mouse EAE model, Vimirogant hydrochloride (p.o.) significantly suppresses clinical symptoms, demyelination and mRNA expression of multiple inflammatory markers in the spinal cord. MCE has not independently confirmed the

Biological Activity:Vimirogant (VTP-43742) hydrochloride is a potent, selective, and orally active RORγt inhibitor ( K i =3.5 nM; IC 50 =17 nM). Vimirogant hydrochloride exhibits >1000-fold selectivity versus the RORα and RORβ isotypes. Vimirogant hydrochloride inhibits Th17

Specifications

Specifications & Purity

≥98%

Storage

Store at 2-8°C, Desiccated

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥98%

Names and Identifiers

• Canonical Smiles: O=C(C1=CN=C([C@H](C(C)C)N(C[C@H]2CC[C@H](C(F)(F)F)CC2)C3)C3=C1)NCC4=NC=C(S(=O)(CC)=O)C=C4.Cl.[x]

Chemical and Physical Properties

• Solubility: DMSO : 125 mg/mL (Need ultrasonic) Ethanol : 50 mg/mL (Need ultrasonic)