≥99% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
WM-8014 WM-8014 is a highly potent inhibitor of histone acetyltransferase KAT6A with an IC50 of 8 nM.
Targets
KAT6A (Cell-free assay) 8 nM
In vitro
WM-8014 induces cell cycle arrest in embryonic day (E)14.5 mouse embryonic fibroblasts.Cells treated with WM-8014 failed to proliferate after ten days of treatment (IC50 2.4 μM). Higher doses of WM-8014 (up to 40 μM) did not accelerate growth arrest, which after eight days of treatment was irreversible.
In vivo
WM-8014 potentiates oncogene-induced senescence in a zebrafish model of hepatocellular carcinoma.
| Pubchem Sid | 504773136 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/504773136 |
| Sonrisas canónicas | CC1=CC(=CC(=C1F)C(=O)NNS(=O)(=O)C2=CC=CC=C2)C3=CC=CC=C3 |
| IUPAC Name | N'-(benzenesulfonyl)-2-fluoro-3-methyl-5-phenylbenzohydrazide |
| InChIKey | PHHZKBMVRPULAW-UHFFFAOYSA-N |
| INCHI | 1S/C20H17FN2O3S/c1-14-12-16(15-8-4-2-5-9-15)13-18(19(14)21)20(24)22-23-27(25,26)17-10-6-3-7-11-17/h2-13,23H,1H3,(H,22,24) |
| Isómeros SMILES | CC1=CC(=CC(=C1F)C(=O)NNS(=O)(=O)C2=CC=CC=C2)C3=CC=CC=C3 |
| PubChem CID | 133053564 |
| Peso molecular | 384.42 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Benzenoids |
| Clase | Benzene and substituted derivatives |
| Subclass | Biphenyls and derivatives |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Biphenyls and derivatives |
| Alternative Parents | Benzenesulfonamides 2-halobenzoic acids and derivatives m-Toluamides Benzenesulfonyl compounds Benzoyl derivatives Fluorobenzenes Sulfonohydrazides Hydrazinosulfonyl compounds Aryl fluorides Vinylogous halides Carboxylic acids and derivatives Organopnictogen compounds Organooxygen compounds Organonitrogen compounds Organofluorides Organic oxides Hydrocarbon derivatives |
| Molecular Framework | Aromatic homomonocyclic compounds |
| Substituents | Biphenyl - Halobenzoic acid or derivatives - 2-halobenzoic acid or derivatives - Benzenesulfonamide - Benzenesulfonyl group - M-toluamide - Toluamide - Benzoic acid or derivatives - Benzoyl - Toluene - Halobenzene - Fluorobenzene - Hydrazinosulfonyl compound - Sulfonohydrazide - Aryl halide - Aryl fluoride - Vinylogous halide - Sulfonyl - Organosulfonic acid or derivatives - Organic sulfonic acid or derivatives - Carboxylic acid derivative - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organosulfur compound - Organooxygen compound - Organonitrogen compound - Organofluoride - Organohalogen compound - Aromatic homomonocyclic compound |
| Descripción | This compound belongs to the class of organic compounds known as biphenyls and derivatives. These are organic compounds containing to benzene rings linked together by a C-C bond. |
| External Descriptors | Not available |
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Fecha | Articulo |
|---|---|---|---|
 H2224334 | Certificate of Analysis | Jun 09, 2025 | W413571 |
| H2224335 | Certificate of Analysis | Jun 09, 2025 | W413571 |
| H2224337 | Certificate of Analysis | Jun 09, 2025 | W413571 |
| H2224338 | Certificate of Analysis | Jun 09, 2025 | W413571 |
| Solubilidad | Solubility (25°C) In vitro DMSO: 77 mg/mL (200.3 mM); Water: Insoluble; Ethanol: Insoluble; |
|---|---|
| Peso molecular | 384.400 g/mol |
| XLogP3 | 4.100 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 5 |
| Rotatable Bond Count | 5 |
| Exact Mass | 384.094 Da |
| Monoisotopic Mass | 384.094 Da |
| Topological Polar Surface Area | 83.700 Ų |
| Heavy Atom Count | 27 |
| Formal Charge | 0 |
| Complexity | 595.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
