(Z)-4EGI-1 - ≥98% , CAS No.901787-88-0

CAS: 901787-88-0 Cat. No.: E650643 Fórmula: C₁₈H₁₂Cl₂N₄O₄S Peso molecular: 451.28

GRADE & PURITY ≥98%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Descripción general

(Z)-4EGI-1 is the Z-isomer of 4EGI-1 and is an inhibitor of eIF4E/eIF4G interaction and of translation initiation . (Z)-4EGI-1 effectively binds to eIF4E with an IC 50 of 43.5 μM and a K d value of 8.74 μM. (Z)-4EGI-1 has anticancer activity

In Vitro

(Z)-4EGI-1 (15-30 µM; 6 hours; CRL-2813 melanoma cells) treatment markedly reduces the expressions of the regulatory proteins: cyclin D1, cyclin E, and Survivin, while the expressions of housekeeping proteins such as β-Actin and α-Tubulin are not affected. (Z)-4EGI-1 inhibits cancer cells proliferation with IC 50 values of 15.3 μM and 11.6 μM for CRL-2351 breast cells and CRL-2813 melanoma cells, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: CRL-2813 melanoma cells Concentration: 15 µM, 30 µM Incubation Time: 6 hours Result: Markedly reduced the expressions of the regulatory proteins: cyclin D1, cyclin E, and Survivin.

Form:Solid

IC50& Target:eIF4

Specifications

Especificaciones y pureza

≥98%

Mecanismos bioquímicos y fisiológicos

(Z)-4EGI-1 is the Z-isomer of 4EGI-1 and is an inhibitor of eIF4E/eIF4G interaction and of translation initiation . (Z)-4EGI-1 effectively binds to eIF4E with an IC 50 of 43.5 μM and a K d value of 8.74 μM. (Z)-4EGI-1 has anticancer activity.

Condiciones de almacenamiento de almacenamiento

Store at -20°C

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Tipo de acción

INHIBITOR

Pureza

≥98%

Nombres e identificadores

• Peso molecular: 451.28

Propiedades químicas y físicas

• Solubilidad: DMSO : 50 mg/mL (110.80 mM; ultrasonic and warming and heat to 60°C)

Preguntas frecuentes

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 901787-88-0, the molecular formula is C18H12Cl2N4O4S, and the molecular weight is 451.28 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.