Protocols

Plasma cell leukemia detection assay

Summary

Blood picture: most cases have moderate anemia, usually of the normocytic orthochromatic type, but also of the hypochromatic type, total leukocyte counts are mostly elevated, up to (10-90) × 109/L, and a large number of plasma cells can be seen in the blood film, greater than 20% or an absolute value of greater than or equal to 2 × 109/L, including primitive and naïve plasma cells, with an abnormal morphology, a decrease in the platelet count, and a significant increase in the sedimentation rate. Obviously increased speed. This experiment was obtained from the laboratory instruction of Mudanjiang Medical College undergraduate 5-year testing program.

Operation method

Plasma cell leukemia detection assay

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Blood picture: most cases have moderate anemia, usually of the normocytic orthochromatic type, but also of the hypochromatic type, the total number of leukocytes is mostly elevated, up to (10-90) × 109/L, and a large number of plasma cells can be seen in the blood film, greater than 20% or an absolute value of greater than or equal to 2 × 109/L, including primitive and naïve plasma cells, with an abnormal morphology, a decrease in the number of platelets, and a significant increase in the sedimentation rate. 明显增快。

Bone marrow image: myeloproliferative activity is extremely active or obviously active, all stages of abnormal plasma cells in the bone marrow are obviously proliferated, up to 10-92%, including primary plasma cells, young plasma cells, small plasma cells and reticulocyte-like plasma cells, plasma cell maturity and morphology are very inconsistent, the shape of the body is generally small, rounded oblong or oval, the nucleus is more naïve, the nucleolus is obvious, the nuclear staining is very sparse, the nuclear and plasma development is not balanced. Plasma cell leukemia should be distinguished from multiple myeloma and reactive plasmacytosis.


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Da — when not otherwise indicated, molecular weight units are daltons.   Mw — weight-average molecular weight.   Mn — number-average molecular weight.

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Aladdin Scientific. "Plasma cell leukemia detection assay" Aladdin Knowledge Base, updated Dec 24, 2024. https://www.aladdinsci.com/us_en/faqs/plasma-cell-leukemia-detection-assay-en.html
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