360A iodide is a selective stabilizer of G-quadruplex , and also inhibits telomerase activity with an IC 50 of 300 nM for telomerase in TRAP-G4 assay.
In Vitro
360A iodide inhibits telomerase activity and stabilizes G-quadruplex, with an IC 50 of 300 nM for telomerase in TRAP-G4 assay. 360A reduces the viability of glioma cell lines, such as T98G, CB193, U118-MG, SAOS-2 and Primary astrocytes, with IC 50 s of 4.8 ± 1.1 μM, 3.9 ± 0.4 μM, 8.4 ± 0.5 μM, >15 μM and 17.4 ± 1.2 μM, respectively. 360A causes Rad51-dependent telomere aberrations preferentially involving the lagging strand telomeres, including telomere losses or telomere doublets, and induces DNA-PKcs-dependent sister telomere fusions. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
360A iodide is a selective stabilizer of G-quadruplex , and also inhibits telomerase activity with an IC 50 of 300 nM for telomerase in TRAP-G4 assay.
Condizioni di conservazione di stoccaggio
Store at 2-8°C,Desiccated
Spedito in
Wet ice
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Tipo di azione
ACTIVATOR
Purezza
≥98%
Nomi e identificatori
Peso molecolare
703.31
Dati avanzati
Certificati (CoA, COO, BSE/TSE e tabella di analisi)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Proprietà chimiche e fisiche
Solubilità
DMSO : 2 mg/mL (2.84 mM; Need ultrasonic)
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Recensioni
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What is the purity of this product?
This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.
How should this product be stored?
Store at 2–8 °C, desiccated. Keep the container tightly closed with desiccant — the material is moisture-sensitive.
How is this product shipped?
This product ships chilled on wet ice. Unpack on arrival and transfer it to the storage condition stated above.
What are the CAS number, molecular formula and molecular weight?
The CAS Number is 737763-37-0, the molecular formula is C27H23I2N5O2, and the molecular weight is 703.31 g/mol.
What documentation is provided?
Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.
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