Ciclo cellulare/Danno al DNA

Esplora le piccole molecole correlate al controllo del ciclo cellulare e alle vie di risposta al danno al DNA per la ricerca oncologica, gli studi sui checkpoint e lo sviluppo di test. Utilizza questa categoria per confrontare i composti rilevanti per il controllo della proliferazione, i meccanismi di riparazione e la segnalazione della risposta allo stress.

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Mostrando 1-12 di 9,024

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  1. Iisoindigotin
    CAS: 476-34-6 Formula: C16H10N2O2 Peso molecolare: 262.26
    Solido Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ◐ .Su ordinazione · 8–12 settimane Oggetto #: I303788
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    Nome IUPAC
    3-(2-hydroxy-1H-indol-3-yl)indol-2-one
    SMILES
    C1=CC=C2C(=C1)C(=C(N2)O)C3=C4C=CC=CC4=NC3=O
    InChIKey
    VBMISAYWIMDRCV-UHFFFAOYSA-N
    InChI
    1S/C16H10N2O2/c19-15-13(9-5-1-3-7-11(9)17-15)14-10-6-2-4-8-12(10)18-16(14)20/h1-8,17,19H
    Sinonimi
    SR-01000390554 | (3E)-3-(2-oxo-1H-indol-3-ylidene)-1H-indol-2-one | 3-(2-hydroxy-1H-indol-3-yl)indol-2-one | SCHEMBL1...
  2. GSK2850163
    CAS: 2121989-91-9 PubChem CID: 73291790 Formula: C24H29Cl2N3O Peso molecolare: 446.41
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ◐ .Su ordinazione · 8–12 settimane Oggetto #: G650135
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    (5R)-2-[(3,4-dichlorophenyl)methyl]-N-[(4-methylphenyl)methyl]-2,7-diazaspiro[4.5]decane-7-carboxamide
    SMILES
    CC1=CC=C(C=C1)CNC(=O)N2CCCC3(C2)CCN(C3)CC4=CC(=C(C=C4)Cl)Cl
    InChIKey
    YFDASBFQKMHSSJ-XMMPIXPASA-N
    InChI
    1S/C24H29Cl2N3O/c1-18-3-5-19(6-4-18)14-27-23(30)29-11-2-9-24(17-29)10-12-28(16-24)15-20-7-8-21(25)22(26)13-20/h3-8,13H,2,9-12,14-17H2,1H3,(H,27,30)/t2show more
    Sinonimi
    (R)-2-(3,4-Dichlorobenzyl)-N-(4-methylbenzyl)-2,7-diazaspiro[4.5]decane-7-carboxamide | Gsk2850163
  3. Ceramides Mixture
    CAS: 100403-19-8 Numero EC: 309-560-3 PubChem CID: 74945544
    Solido ≥95%
    ● In magazzino — Magazzino negli USA, spedizione nell'EU* Oggetto #: C647629
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    N-(1,3,4-trihydroxyoctadecan-2-yl)octadec-9-enamide
    SMILES
    CCCCCCCCCCCCCCC(C(C(CO)NC(=O)CCCCCCCC=CCCCCCCCC)O)O
    InChIKey
    ATGQXSBKTQANOH-UHFFFAOYSA-N
    InChI
    1S/C36H71NO4/c1-3-5-7-9-11-13-15-17-18-19-21-23-25-27-29-31-35(40)37-33(32-38)36(41)34(39)30-28-26-24-22-20-16-14-12-10-8-6-4-2/h17-18,33-34,36,38-39,show more
    Sinonimi
    Ceramide 3 | SY343426 | N-[(2S,3S,4R)-1,3,4-Trihydroxy-2-octadecyl]oleamide | FT-0623551
  4. DAPI Staining Solution
    Liquido Sterile-filtered ? Sterile-filtered — passed through a 0.2µm filter to remove microorganisms. Use as a ready aseptic solution for culture and sensitive applications. Suitable for Immunofluorescence(IF) ? IF grade — validated for immunofluorescence with low background staining. Use to localize targets in cells/tissue by fluorescence microscopy. BioReagent ? BioReagent grade — tested suitable for life-science and molecular-biology use. Use for cell culture, assays, and biochemical work needing biological compatibility. for Microscopy ? Microscopy grade — reagents/stains suited to sample prep and imaging. Use in microscopy where clarity and low background are needed. 1.0 mg/mL
    ● In magazzino — Magazzino negli USA, spedizione nell'EU* Oggetto #: D1372407
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    DAPI | DAPI Staining Solution | DAPI Reagent | DAPI Stain | DAPI Solution
  5. Hoechst 33342 Staining Solution
    CAS: 23491-52-3 Numero EC: 245-691-1 Formula: C27H28N6O • 3HCl • xH2O Peso molecolare: 561.93(anhydrous basis)
    Liquido Suitable for Immunofluorescence(IF) ? IF grade — validated for immunofluorescence with low background staining. Use to localize targets in cells/tissue by fluorescence microscopy. BioReagent ? BioReagent grade — tested suitable for life-science and molecular-biology use. Use for cell culture, assays, and biochemical work needing biological compatibility. Ready-to-use ? Ready-to-use — supplied pre-formulated at working concentration, no prep needed. Use to save time and reduce pipetting/dilution errors. Biological Stain ? Biological stain grade — dyes characterized for staining cells and tissues. Use in histology and microscopy where staining consistency matters. for Fluorescence analysis ? Fluorescence-analysis grade — very low fluorescent impurities for clean spectra. Use in fluorescence assays where background interferes. Biological dye grade ? Biological stain grade — dyes characterized for staining cells and tissues. Use in histology and microscopy where staining consistency matters. for Microscopy ? Microscopy grade — reagents/stains suited to sample prep and imaging. Use in microscopy where clarity and low background are needed. for Cell culture ? Cell-culture grade — low endotoxin and contaminants to support viable cell growth. Use in mammalian/other cell culture media and supplements. 1.0 mg/ml in H₂O
    ● In magazzino — Magazzino negli USA, spedizione nell'EU* Oggetto #: O1501802
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    Sinonimi
    Hoechst 33342 Stain Solution (1 mg/mL) | Hoechst 33342 Staining Solution for Live Cells, 100X | Hoechst 33342 Solution
  6. Hoechst 33258 staining solution
    CAS: 23491-45-4 Numero EC: 245-690-6 PubChem CID: 31953 Formula: C25H24N6O·3HCl Peso molecolare: 533.90
    Liquido Suitable for Immunofluorescence(IF) ? IF grade — validated for immunofluorescence with low background staining. Use to localize targets in cells/tissue by fluorescence microscopy. BioReagent ? BioReagent grade — tested suitable for life-science and molecular-biology use. Use for cell culture, assays, and biochemical work needing biological compatibility. Ready-to-use ? Ready-to-use — supplied pre-formulated at working concentration, no prep needed. Use to save time and reduce pipetting/dilution errors. Biological Stain ? Biological stain grade — dyes characterized for staining cells and tissues. Use in histology and microscopy where staining consistency matters. for Fluorescence analysis ? Fluorescence-analysis grade — very low fluorescent impurities for clean spectra. Use in fluorescence assays where background interferes. Biological dye grade ? Biological stain grade — dyes characterized for staining cells and tissues. Use in histology and microscopy where staining consistency matters. for Microscopy ? Microscopy grade — reagents/stains suited to sample prep and imaging. Use in microscopy where clarity and low background are needed. for Cell culture ? Cell-culture grade — low endotoxin and contaminants to support viable cell growth. Use in mammalian/other cell culture media and supplements. 1.0 mg/mL in H₂O
    ● In magazzino — Magazzino negli USA, spedizione nell'EU* Oggetto #: H1373484
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    Sinonimi
    Hoechst 33258 | Hoechst 33258 Stain Solution | Hoechst 33258 Stain Solution(1mg/ml) | Hoechst 33258 Staining Dye Solu...
  7. Sertaconazole nitrate, Cytochrome P450 51 inhibitor
    CAS: 99592-39-9 PubChem CID: 200103 Formula: C20H15Cl3N2OS·HNO3 Peso molecolare: 500.78
    ● In magazzino — Magazzino negli USA, spedizione nell'EU* Oggetto #: S129395
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    1-[2-[(7-chloro-1-benzothiophen-3-yl)methoxy]-2-(2,4-dichlorophenyl)ethyl]imidazole;nitric acid
    SMILES
    C1=CC2=C(C(=C1)Cl)SC=C2COC(CN3C=CN=C3)C4=C(C=C(C=C4)Cl)Cl.[N+](=O)(O)[O-]
    InChIKey
    HAAITRDZHUANGT-UHFFFAOYSA-N
    InChI
    1S/C20H15Cl3N2OS.HNO3/c21-14-4-5-16(18(23)8-14)19(9-25-7-6-24-12-25)26-10-13-11-27-20-15(13)2-1-3-17(20)22;2-1(3)4/h1-8,11-12,19H,9-10H2;(H,2,3,4)
    Sinonimi
    HMS1571A12 | CAS-99592-39-9 | A851341 | 1-{2-[(7-chloro-1-benzothiophen-3-yl)methoxy]-2-(2,4-dichlorophenyl)ethyl}-1H...
  8. GW 1929 hydrochloride
    CAS: 1217466-21-1 PubChem CID: 56972174 Formula: C30H29N3O4•HCl Peso molecolare: 532.03
    ◐ .Su ordinazione · 8–12 settimane Oggetto #: G286659
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    (2S)-2-(2-benzoylanilino)-3-[4-[2-[methyl(pyridin-2-yl)amino]ethoxy]phenyl]propanoic acid;hydrochloride
    SMILES
    CN(CCOC1=CC=C(C=C1)CC(C(=O)O)NC2=CC=CC=C2C(=O)C3=CC=CC=C3)C4=CC=CC=N4.Cl
    InChIKey
    KXNKIKXTGRMLEY-YCBFMBTMSA-N
    InChI
    1S/C30H29N3O4.ClH/c1-33(28-13-7-8-18-31-28)19-20-37-24-16-14-22(15-17-24)21-27(30(35)36)32-26-12-6-5-11-25(26)29(34)23-9-3-2-4-10-23;/h2-18,27,32H,19-show more
    Sinonimi
    N-(2-Benzoylphenyl)-O-[2-(methyl-2-pyridinylamino)ethyl]-L-tyrosine hydrochloride
  9. Lumbrokinase
    CAS: 556743-18-1
    Solido EnzymoPure™ ? EnzymoPure™ — Aladdin's line of high-quality enzymatic solutions. Use when enzyme purity and defined activity drive assay or process performance. ≥12000U/mg
    ● In magazzino — Magazzino negli USA, spedizione nell'EU* Oggetto #: L115121
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    Specie
    Earthworm
    Bioattività
    ≥12000U/mg
  10. NCH 51
    CAS: 848354-66-5 Formula: C20H26N2O2S2 Peso molecolare: 390.57
    ● In magazzino — Magazzino negli USA, spedizione nell'EU* Oggetto #: N274711
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    S-[7-oxo-7-[(4-phenyl-1,3-thiazol-2-yl)amino]heptyl] 2-methylpropanethioate
    SMILES
    CC(C)C(=O)SCCCCCCC(=O)NC1=NC(=CS1)C2=CC=CC=C2
    InChIKey
    MDYDGUOQFUQOGE-UHFFFAOYSA-N
    InChI
    1S/C20H26N2O2S2/c1-15(2)19(24)25-13-9-4-3-8-12-18(23)22-20-21-17(14-26-20)16-10-6-5-7-11-16/h5-7,10-11,14-15H,3-4,8-9,12-13H2,1-2H3,(H,21,22,23)
    Sinonimi
    S-[7-oxo-7-[(4-phenyl-1,3-thiazol-2-yl)amino]heptyl] 2-methylpropanethioate | dibenzo[b,d]furan-4-yl boronic acid | N...
  11. Retaspimycin
    CAS: 857402-23-4 Formula: C31H45N3O8 Peso molecolare: 587.7
    ◐ .Su ordinazione · 8–12 settimane Oggetto #: R127859
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    [(4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13,20,22-trihydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3-oxo-19-(prop-2-enylamino)-2-azabicyclo[16.3.1]docosa-1(show more
    SMILES
    CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=C(C(=C2O)C1)NCC=C)O)C)OC)OC(=O)N)C)C)O)OC
    InChIKey
    OAKGNIRUXAZDQF-TXHRRWQRSA-N
    InChI
    1S/C31H45N3O8/c1-8-12-33-26-21-13-17(2)14-25(41-7)27(36)19(4)15-20(5)29(42-31(32)39)24(40-6)11-9-10-18(3)30(38)34-22(28(21)37)16-23(26)35/h8-11,15-17,show more
    Sinonimi
    D09375 | IPI-504 | (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13,20,22-Trihydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3-oxo-...
  12. Retinoic acid
    CAS: 302-79-4 Numero EC: 206-129-0 Formula: C20H28O2 Peso molecolare: 300.44
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● In magazzino — Magazzino negli USA, spedizione nell'EU* Oggetto #: R106320
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    (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoic acid
    SMILES
    CC1=C(C(CCC1)(C)C)C=CC(=CC=CC(=CC(=O)O)C)C
    InChIKey
    SHGAZHPCJJPHSC-YCNIQYBTSA-N
    InChI
    1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14+
    Sinonimi
    (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic acid | TRETINOIN COMPONENT OF...
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Domande frequenti

What should I compare when selecting Cell Cycle/DNA Damage?
Within Cell Cycle/DNA Damage, compare source and expression system, purity and the method used to measure it, specific activity, and buffer composition. In a sensitive assay the buffer can matter as much as the protein itself.
Which Cell Cycle/DNA Damage subcategory should I start with?
Cell Cycle/DNA Damage is organised into Antifolate, APC, ATF6, ATM/ATR and Aurora Kinase, and 48 further subcategories. Choose by the workflow step you are at rather than by molecule type — most workflows draw from more than one subcategory.
Which quality data should I review before ordering Cell Cycle/DNA Damage?
Review the lot-specific Certificate of Analysis for the Cell Cycle/DNA Damage product — purity, activity, and endotoxin — and confirm the buffer and any carrier protein. Carrier-free formats are worth specifying where downstream labelling or conjugation is planned. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.
What documentation is available for Cell Cycle/DNA Damage?
Each Cell Cycle/DNA Damage product page links a datasheet and a lot-specific Certificate of Analysis covering purity, activity, and storage. For lot reservations, bulk quantities, or documentation not shown, contact [email protected].

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