8-OH-DPAT (8-Hydroxy-DPAT) - Moligand™, 10mM in DMSO , Agonist of 5-HT 1A receptor;Agonist of 5-HT 1B receptor;Agonist of 5-HT 1D receptor;Agonist of 5-ht 1e receptor;Agonist of 5-HT 1F receptor;Agonist of 5-HT 2A receptor;Agonist of 5-HT 2B receptor;Agon, Agonist of 5-HT 1A receptor;Agonist of 5-HT 1B receptor;Agonist of 5-HT 1D receptor;Agonist of 5-ht 1e receptor;Agonist of 5-HT 1F receptor;Agonist of 5-HT 2A receptor;Agonist of 5-HT 2B receptor;Agonist of 5-HT 2C receptor;Agonist of 5-HT 5A receptor;Ago

CAS: 78950-78-4 Cat. No.: O425963 Formula: C₁₆H₂₅NO Peso molecolare: 247.19

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

CCG-204665 | DPAT | 8-hydroxy-n,n-dipropyl-2-aminotetralin | (R)-8-Hydroxy-2-dipropylaminotetralin | Q4644282 | 7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-ol | DTXSID30897384 | [3H]-8-OH-DPAT | [3H]8-OH-DPAT | EX-A2914 | 8-HYDROXY-2-(DI-n-PROPYLAMIN

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Panoramica

Information

8-OH-DPAT (8-Hydroxy-DPAT) is a kind of classic5-HT1Aagonist with the pIC50 of 8.19. It has a selectivity of almost-1000 fold for a subtype of the 5-HT1 binding site; Its biological half-life is 1.5 hous.

Targets

5-HT1A (Cell-free) 8.19(pIC50)

In vitro

The drug is only weakly effective at 5-HT1B subtype, the pIC50 being 5.42 ± 0.08 (n = 5). Since 8-OH-DPAT has no effect on 5-HT1B binding at concentrations lower than 100 nM. 8-OH-DPAT is able to reduce the accumulation of both autophagic-derived and photoreceptor outer segment-derived lipofuscin, increase antioxidant protection and reduce oxidative damage in cultured human RPE cells.

In vivo

Intravenous administration of the selective 5-HT1A-receptor agonist 8-OH-DPAT rapidly reverses the hypotensive and bradycardic responses established during severe hemorrhage with relatively little variability. 8-OH-DPAT is relatively lipophilic and readily crosses the blood-brain barrier.

Cell Research(from reference)

Cell lines：Retinal pigment epithelial (RPE) cells 

Concentrations：10 μM 

Incubation Time：24 h 

Specifications

Sinonimi

CCG-204665 | DPAT | 8-hydroxy-n,n-dipropyl-2-aminotetralin | (R)-8-Hydroxy-2-dipropylaminotetralin | Q4644282 | 7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-ol | DTXSID30897384 | [3H]-8-OH-DPAT | [3H]8-OH-DPAT | EX-A2914 | 8-HYDROXY-2-(DI-n-PROPYLAMIN

Specifiche e purezza

Moligand™, 10mM in DMSO

Meccanismi biochimici e fisiologici

8-OH-DPAT (8-Hydroxy-DPAT) is a kind of classic 5-HT1A agonist with the pIC50 of 8.19. It has a selectivity of almost-1000 fold for a subtype of the 5-HT1 binding site; Its biological half-life is 1.5 hous.

Condizioni di conservazione di stoccaggio

Store at -80°C

Spedito in

Dry ice packs + Cold packs

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Grado

Moligand™

Tipo di azione

AGONIST

Meccanismo d'azione

Agonist of 5-HT 1A receptor;Agonist of 5-HT 1B receptor;Agonist of 5-HT 1D receptor;Agonist of 5-ht 1e receptor;Agonist of 5-HT 1F receptor;Agonist of 5-HT 2A receptor;Agonist of 5-HT 2B receptor;Agonist of 5-HT 2C receptor;Agonist of 5-HT 5A receptor;Ago

Nomi e identificatori

• Pubchem Sid: 528762914
• Sorrisi canonici: CCCN(CCC)C1CCC2=C(C1)C(=CC=C2)O
• IUPAC Name: 7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-ol
• InChIKey: ASXGJMSKWNBENU-UHFFFAOYSA-N
• INCHI: 1S/C16H25NO/c1-3-10-17(11-4-2)14-9-8-13-6-5-7-16(18)15(13)12-14/h5-7,14,18H,3-4,8-12H2,1-2H3
• Isomeri SMILES: CCCN(CCC)C1CCC2=C(C1)C(=CC=C2)O
• CAS alternativo: 78950-78-4
• Termini MeSH: 8-Hydroxy-2-(di-n-propylamino)tetralin;8-Hydroxy-2-(di-n-propylamino)tetralin Hydrobromide;8-Hydroxy-2-(di-n-propylamino)tetralin Hydrobromide, (+-)-Isomer;8-Hydroxy-2-(di-n-propylamino)tetralin Hydrobromide, (R)-Isomer,;8-Hydroxy-2-(di-n-propylamino)tetr
• Peso molecolare: 247.19
• Reaxy-Rn: 3546291
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=3546291&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Classe Tetralins

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Classe: Tetralins
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Tetralins
• Alternative Parents: Aralkylamines 1-hydroxy-4-unsubstituted benzenoids 1-hydroxy-2-unsubstituted benzenoids Trialkylamines Organopnictogen compounds Organooxygen compounds Hydrocarbon derivatives
• Molecular Framework: Aromatic homopolycyclic compounds
• Substituents: Tetralin - 1-hydroxy-4-unsubstituted benzenoid - 1-hydroxy-2-unsubstituted benzenoid - Aralkylamine - Tertiary aliphatic amine - Tertiary amine - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Amine - Aromatic homopolycyclic compound
• Descrizione: This compound belongs to the class of organic compounds known as tetralins. These are polycyclic aromatic compounds containing a tetralin moiety, which consists of a benzene fused to a cyclohexane.
• External Descriptors: tertiary amino compound - phenols - tetralins

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

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HTR2C Tclin 5-hydroxytryptamine receptor 2C (1 Activities)

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Meccanismi d'azione

Proprietà chimiche e fisiche

• Peso molecolare: 247.380 g/mol
• XLogP3: 4.100
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 247.194 Da
• Monoisotopic Mass: 247.194 Da
• Topological Polar Surface Area: 23.500 Ų
• Heavy Atom Count: 18
• Formal Charge: 0
• Complexity: 237.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 1
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1