ARRY 520 trifluoroacetate - ≥98%(HPLC) , CAS No.1781834-99-8

CAS: 1781834-99-8 Cat. No.: A287172 Molecular Weight: 534.50 PubChem CID: 90488964

GRADE & PURITY ≥98%(HPLC)

Synonyms

Filanesib | (2S)-2-(3-Aminopropyl)-5-(2,5-difluorophenyl)-N-methoxy-N-methyl-2-phenyl-1,3,4-thiadiazole-3(2H)-carboxamide trifluoroacetate | Filanesib TFA | ARRY-520 TFA

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Specifications

Synonyms

Filanesib | (2S)-2-(3-Aminopropyl)-5-(2, 5-difluorophenyl)-N-methoxy-N-methyl-2-phenyl-1, 3, 4-thiadiazole-3(2H)-carboxamide trifluoroacetate | Filanesib TFA | ARRY-520 TFA

Specifications & Purity

≥98%(HPLC)

Biochemical and Physiological Mechanisms

Potent kinesin spindle protein (KSP) inhibitor (IC50= 6 nM); selective for KSP over >250 other receptors and kinases at a concentration of 10μM. Displays robust antitumor activity in bortezomib-resistant xenografts either alone or in combination with bort

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Purity

≥98%(HPLC)

Names and Identifiers

• Canonical Smiles: CN(C(=O)N1C(SC(=N1)C2=C(C=CC(=C2)F)F)(CCCN)C3=CC=CC=C3)OC.C(=O)(C(F)(F)F)O
• IUPAC Name: (2S)-2-(3-aminopropyl)-5-(2,5-difluorophenyl)-N-methoxy-N-methyl-2-phenyl-1,3,4-thiadiazole-3-carboxamide;2,2,2-trifluoroacetic acid
• InChIKey: CIJUJPVFECBUKG-BDQAORGHSA-N
• INCHI: 1S/C20H22F2N4O2S.C2HF3O2/c1-25(28-2)19(27)26-20(11-6-12-23,14-7-4-3-5-8-14)29-18(24-26)16-13-15(21)9-10-17(16)22;3-2(4,5)1(6)7/h3-5,7-10,13H,6,11-12,23H2,1-2H3;(H,6,7)/t20-;/m0./s1
• Isomeric SMILES: CN(C(=O)N1[C@](SC(=N1)C2=C(C=CC(=C2)F)F)(CCCN)C3=CC=CC=C3)OC.C(=O)(C(F)(F)F)O
• PubChem CID: 90488964
• Molecular Weight: 534.50

Chemical and Physical Properties

• Solubility: Solvent:DMSO, Max Conc. mg/mL: 31.54, Max Conc. mM: 75; Solvent:ethanol, Max Conc. mg/mL: 31.54, Max Conc. mM: 75