Bilastine - Moligand™, ≥98%(HPLC)(T) , Histamine H1 receptor inverse agonist, CAS No.202189-78-4, Histamine H1 receptor inverse agonist

CAS: 202189-78-4 Cat. No.: B405700 Formula: C₂₈H₃₇N₃O₃ Peso molecolare: 463.62 Numero EC: 824-988-5

GRADE & PURITY Moligand™, ≥98%(HPLC)(T)

Synonyms

2-(4-(2-(4-(1-(2-ethoxyethyl)-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)ethyl)phenyl)-2-methylpropanoic acid | MFCD09837814 | GTPL11579 | HY-14447 | BS-15792 | NCGC00262907-01 | 2-[4-(2-{4-[1-(2-ethoxy-ethyl)-1H-benzoimidazol-2-yl]-piperidin-1-yl}-ethyl)-ph

Storage

Store at 2-8°C

Shipped In

Wet ice

Specifications

Sinonimi

2-(4-(2-(4-(1-(2-ethoxyethyl)-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)ethyl)phenyl)-2-methylpropanoic acid | MFCD09837814 | GTPL11579 | HY-14447 | BS-15792 | NCGC00262907-01 | 2-[4-(2-{4-[1-(2-ethoxy-ethyl)-1H-benzoimidazol-2-yl]-piperidin-1-yl}-ethyl)-ph

Specifiche e purezza

Moligand™, ≥98%(HPLC)(T)

Meccanismi biochimici e fisiologici

Bilastine is an orally available, potent and selective histamine H1 receptor antagonist that exhibits long drug-target residence time at H1 receptor (73 min), which results in extended H1 receptor antagonism in vitro. Bilastine is used for treatment of al

Condizioni di conservazione di stoccaggio

Store at 2-8°C

Spedito in

Wet ice

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Grado

Moligand™

Tipo di azione

ANTAGONIST, INVERSE AGONIST

Meccanismo d'azione

Histamine H1 receptor inverse agonist

Purezza

≥98%(HPLC)(T)

Proprietà del prodotto

• ALogP: 2.3

Nomi e identificatori

• Pubchem Sid: 504757730
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504757730
• Sorrisi canonici: CCOCCN1C2=CC=CC=C2N=C1C3CCN(CC3)CCC4=CC=C(C=C4)C(C)(C)C(=O)O
• IUPAC Name: 2-[4-[2-[4-[1-(2-ethoxyethyl)benzimidazol-2-yl]piperidin-1-yl]ethyl]phenyl]-2-methylpropanoic acid
• InChIKey: ACCMWZWAEFYUGZ-UHFFFAOYSA-N
• INCHI: 1S/C28H37N3O3/c1-4-34-20-19-31-25-8-6-5-7-24(25)29-26(31)22-14-17-30(18-15-22)16-13-21-9-11-23(12-10-21)28(2,3)27(32)33/h5-12,22H,4,13-20H2,1-3H3,(H,32,33)
• Isomeri SMILES: CCOCCN1C2=CC=CC=C2N=C1C3CCN(CC3)CCC4=CC=C(C=C4)C(C)(C)C(=O)O
• Peso molecolare: 463.62
• Reaxy-Rn: 13851185
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=13851185&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Classe Benzimidazoles

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Classe: Benzimidazoles
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Benzimidazoles
• Alternative Parents: Phenylpropanes Phenethylamines Aralkylamines Piperidines N-substituted imidazoles Heteroaromatic compounds Trialkylamines Amino acids Azacyclic compounds Carboxylic acids Dialkyl ethers Monocarboxylic acids and derivatives Organic oxides Organopnictogen compounds Carbonyl compounds Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Benzimidazole - Phenylpropane - Phenethylamine - Aralkylamine - Monocyclic benzene moiety - N-substituted imidazole - Benzenoid - Piperidine - Azole - Imidazole - Heteroaromatic compound - Amino acid or derivatives - Amino acid - Tertiary aliphatic amine - Tertiary amine - Carboxylic acid derivative - Carboxylic acid - Dialkyl ether - Ether - Monocarboxylic acid or derivatives - Azacycle - Organic nitrogen compound - Amine - Carbonyl group - Organic oxygen compound - Hydrocarbon derivative - Organopnictogen compound - Organic oxide - Organonitrogen compound - Organooxygen compound - Aromatic heteropolycyclic compound
• Descrizione: This compound belongs to the class of organic compounds known as benzimidazoles. These are organic compounds containing a benzene ring fused to an imidazole ring (five member ring containing a nitrogen atom, 4 carbon atoms, and two double bonds).
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Obiettivi associati (umani)

HRH1 Tclin Histamine H1 receptor (0 Activities)

Discover Target: HRH1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Obiettivi associati (non umani)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Meccanismi d'azione

Proprietà chimiche e fisiche

• Solubilità: Insoluble in water; Very slightly soluble in Ethanol; Insoluble in Methanol
• Punto di fusione (°C): 202 °C
• Peso molecolare: 463.600 g/mol
• XLogP3: 2.300
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 10
• Exact Mass: 463.283 Da
• Monoisotopic Mass: 463.283 Da
• Topological Polar Surface Area: 67.600 Ų
• Heavy Atom Count: 34
• Formal Charge: 0
• Complexity: 641.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1