Information
Carbenicillin (BRL-2064) is a semi-synthetic penicillin antibiotic which interferes with cell wall synthesis of gram-negative bacteria while displaying low toxicity.
In vitro
Carbenicillin (125 mg/L) completely suppresses the proliferation of Agrobacterium. Carbenicillin (250 mg/L-500 mg/L) enhances Callus fresh weight increase. Carbenicillin (125 mg/L) results in higher percentages of somatic embryos and larger numbers of somatic embryos from the individual callus. Carbenicillin (1g/L) influences shoot formation negatively as the shooting frequency for leaf disc explants is reduced to 56% and for cotyledons to 51% after 2 months of culture of Nicotiana tabacum Petit Havana. Carbenicillin prevents the development of mature somatic embryos, reduces early stage embryos by >90% and tissue growth by 50% of Sitka spruce. The leukocytes of the patients does not release histamine on in vitro provocation with Carbenicillin (0.1 g/mL).
In vivo
Carbenicillin (0.1 g/mL) does not show any allergic drug reactions in cystic fibrosis patients, as evident by no significant levels of antibodies of IgE, IgG or IgM classes. Carbenicillin (50 μg/mL) results in phytotoxicity in chrysanthemum and TOB, with an increase in the concentration, and with a parallel shift in the morphogenic capacity (SRC) of threshold survival levels (TSLs). Carbenicillin results in 100% acclimatization with no different morphological flowering characteristics following subculture in vitro three times in Chrysanthemum plantlets.
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