CDK9-IN-2 - Moligand™,≥99% , CAS No.1263369-28-3

CAS: 1263369-28-3 Cat. No.: C651682 Formula: C23H25ClFN5 Peso molecolare: 425.93 PubChem CID: 49855228
Disponibile su ordine
GRADE & PURITY Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥99%
Synonyms
N2'-(trans-4-Aminocyclohexyl)-5'-chloro-N6-(3-fluorobenzyl)-[2,4'-bipyridine]-2',6-diamine
Storage
Protected from light,Store at -20°C,Argon charged
Shipped In
Ice chest + Ice pads
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Size
Germania (EU)
USA*
Price
Qty
1mg
C651682-1mg
Su ordinazione · 8–12 settimane
60,65€
5mg
C651682-5mg
Su ordinazione · 8–12 settimane
156,11€
10mg
C651682-10mg
Su ordinazione · 8–12 settimane
231,60€
50mg
C651682-50mg
Su ordinazione · 8–12 settimane
520,56€
100mg
C651682-100mg
Su ordinazione · 8–12 settimane
780,88€
Enter a quantity for the sizes you want to add.
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Why this grade

Moligand™, ≥99% Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Protected from light,Store at -20°C,Argon charged Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Panoramica

CDK9-IN-2 is a special cyclin-dependent kinase 9 ( CDK9 ) inhibitor, extracted from patent WO/2012131594A1, compound CDKI(8), has an IC 50 of 5 nM and 7 nM in H929 multiple myeloma(MM) cell line (72 hours) and A2058 skin cell line (72 hours), respectively.

In Vitro

CDK9-IN-2 (200 nM) reduces the expression of MEPCE indicating that MEPCE is a pharmacodynamic (PD) marker for any CDK9 inhibitor. The expression of MCL1 protein is reduced 2 hours after treatment and is further reduced after 16 hour exposure to CDK9-IN-2 (500 nM). MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

Specifications

Sinonimi
N2'-(trans-4-Aminocyclohexyl)-5'-chloro-N6-(3-fluorobenzyl)-[2,4'-bipyridine]-2',6-diamine
Specifiche e purezza
Moligand™, ≥99%
Meccanismi biochimici e fisiologici
CDK9-IN-2 is a special cyclin-dependent kinase 9 ( CDK9 ) inhibitor, extracted from patent WO/2012131594A1, compound CDKI(8), has an IC 50 of 5 nM and 7 nM in H929 multiple myeloma(MM) cell line (72 hours) and A2058 skin cell line (72 hours), respectively
Condizioni di conservazione di stoccaggio
Protected from light,Store at -20°C,Argon charged
Spedito in
Ice chest + Ice pads
Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.
Grado
Moligand™
Tipo di azione
INHIBITOR
Purezza
≥99%
Nomi e identificatori
Isomeri SMILES
C1CC(CCC1N)NC2=NC=C(C(=C2)C3=NC(=CC=C3)NCC4=CC(=CC=C4)F)Cl
PubChem CID
49855228
Peso molecolare
425.93

Documentazione

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Certificati (CoA, COO, BSE/TSE e tabella di analisi)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Proprietà chimiche e fisiche
SolubilitàDMSO : 50 mg/mL (117.39 mM; Need ultrasonic)
SensibilitàLight sensitive
Peso molecolare425.900 g/mol
XLogP34.700
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count6
Rotatable Bond Count6
Exact Mass425.178 Da
Monoisotopic Mass425.178 Da
Topological Polar Surface Area75.900 Ų
Heavy Atom Count30
Formal Charge0
Complexity518.000
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
Calcolatori di soluzioni
Recensioni

Recensioni dei clienti

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