CM03 is a potent DNA G-quadruplexes (G4s) ligand. CM03 can stabilise G4s, downregulating more G4-containing genes as well as increasing incidence of double-strand break events (DSBs) due to torsional strain on DNA and chromatin structure. CM03 has selective potency for pancreatic cancer cells
In Vitro
CM03 (0.4 μM; 24 or 48 h) increases the level of γ-H2AX protein when in combination with SAHA in MIA PaCa-2 and PANC-1. CM03 (0-100 nM; 96 h) exhibits highly anti-proliferative activity against pancreatic cancer cell lines. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: MIA PaCa-2 and PANC-1 Concentration: 0.4 μM Incubation Time: 24 h for MIA PaCa-2, 48 h for PANC-1 Result: Significantly increased the level of γ-H2AX protein when in combination with SAHA (1 μM). Cell Proliferation AssayCell Line: MIA PaCa-2, PANC-1, Capan-1 and BxPC-3 Concentration: 0-100 nM Incubation Time: 96 h Result: Exhibited highly anti-proliferative activity against pancreatic cancer cell lines with GI 50 s of 9.0 nM, 15.6 nM, 26.5 nM and 15.5 nM in MIA PaCa-2, PANC-1, Capan-1 and BxPC-3, respectively.
Form:Solid
IC50& Target:DNA synthesis
Specifiche
Specifiche e purezza
≥98%
Meccanismi biochimici e fisiologici
CM03 is a potent DNA G-quadruplexes (G4s) ligand. CM03 can stabilise G4s, downregulating more G4-containing genes as well as increasing incidence of double-strand break events (DSBs) due to torsional strain on DNA and chromatin structure. CM03 has selecti
Condizioni di conservazione di stoccaggio
Store at -20°C
Spedito in
Ice chest + Ice pads
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Certificati (CoA, COO, BSE/TSE e tabella di analisi)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Proprietà chimiche e fisiche
Solubilità
DMSO : 2 mg/mL (3.16 mM; ultrasonic and warming and heat to 60°C)
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Recensioni
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What is the purity of this product?
This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.
How should this product be stored?
Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.
How is this product shipped?
This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.
What are the CAS number, molecular formula and molecular weight?
The CAS Number is 2101208-44-8, the molecular formula is C34H44N6O6, and the molecular weight is 632.75 g/mol.
What documentation is provided?
Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.
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