Doxylamine Succinate - 10mM in DMSO , Histamine H1 receptor antagonist, CAS No.562-10-7, Histamine H1 receptor antagonist

CAS: 562-10-7 Cat. No.: D424761 Formula: C₁₇H₂₂N₂O·C₄H₆O₄ Peso molecolare: 388.46 Numero EC: 209-228-7

QUALITÀ & PUREZZA 10mM in DMSO

Synonyms

Doxylamine succinate|562-10-7|Decapryn|Gittalun|Unisom|Hoggar N|Doxylamine (succinate)|Doxylamine succinate salt|Doxy-sleep-aid|Evigoa D|Decapryn Succinate|Doxylamine hydrogen succinate|Alsadorm|Mereprine|Sedaplus|A-H Injection|Doxylamine succinate (1:1)|

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Panoramica

Doxylamine succinate competitively inhibits histamine at H1 receptors with substantial sedative and anticholinergic effects

Specifiche

Sinonimi

Doxylamine succinate | 562-10-7 | Decapryn | Gittalun | Unisom | Hoggar N | Doxylamine (succinate) | Doxylamine succinate salt | Doxy-sleep-aid | Evigoa D | Decapryn Succinate | Doxylamine hydrogen succinate | Alsadorm | Mereprine | Sedaplus | A-H Injection | Doxylamine succinate (1:1) |

Specifiche e purezza

10mM in DMSO

Meccanismi biochimici e fisiologici

Doxylamine Succinate is an antihistaminic, sedative, and hypnotic. Doxylamine Succinate is also a H1 histamine receptor antagonist.

Condizioni di conservazione di stoccaggio

Store at -80°C

Spedito in

Dry ice packs + Cold packs

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Tipo di azione

ANTAGONIST

Meccanismo d'azione

Histamine H1 receptor antagonist

Nomi e identificatori

Pubchem Sid

528771237

Sorrisi canonici

CC(C1=CC=CC=C1)(C2=CC=CC=N2)OCCN(C)C.C(CC(=O)O)C(=O)O

IUPAC Name

butanedioic acid;N,N-dimethyl-2-(1-phenyl-1-pyridin-2-ylethoxy)ethanamine

InChIKey

KBAUFVUYFNWQFM-UHFFFAOYSA-N

INCHI

1S/C17H22N2O.C4H6O4/c1-17(20-14-13-19(2)3,15-9-5-4-6-10-15)16-11-7-8-12-18-16;5-3(6)1-2-4(7)8/h4-12H,13-14H2,1-3H3;1-2H2,(H,5,6)(H,7,8)

Isomeri SMILES

CC(C1=CC=CC=C1)(C2=CC=CC=N2)OCCN(C)C.C(CC(=O)O)C(=O)O

WGK Germania

2

RTECS

US9275000

Peso molecolare

388.46

Reaxy-Rn

3829474

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=3829474&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Classe Benzene and substituted derivatives
      • Subclass Benzylethers

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Classe: Benzene and substituted derivatives
• Subclass: Benzylethers
• Intermediate Tree Nodes: Not available
• Direct Parent: Benzylethers
• Alternative Parents: Pyridines and derivatives Dicarboxylic acids and derivatives Heteroaromatic compounds Trialkylamines Dialkyl ethers Azacyclic compounds Organopnictogen compounds Hydrocarbon derivatives
• Molecular Framework: Not available
• Substituents: Benzylether - Dicarboxylic acid or derivatives - Pyridine - Heteroaromatic compound - Tertiary aliphatic amine - Tertiary amine - Azacycle - Organoheterocyclic compound - Ether - Dialkyl ether - Amine - Organopnictogen compound - Organooxygen compound - Organonitrogen compound - Organic oxygen compound - Organic nitrogen compound - Hydrocarbon derivative - Aromatic heteromonocyclic compound
• Descrizione: This compound belongs to the class of organic compounds known as benzylethers. These are aromatic ethers with the general formula ROCR' (R = alkyl, aryl; R'=benzene).
• External Descriptors: organic molecular entity

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Obiettivi associati (umani)

VDR Tclin Vitamin D receptor (26531 Activities)

Discover Target: VDR

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EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)

Discover Target: EHMT2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

BLM Tchem Bloom syndrome protein (4248 Activities)

Discover Target: BLM

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GMNN Tbio Geminin (128009 Activities)

Discover Target: GMNN

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MBNL1 Tbio Muscleblind-like protein 1 (34431 Activities)

Discover Target: MBNL1

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SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 Activities)

Discover Target: SLCO1B3

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Obiettivi associati (non umani)

Pseudomonas aeruginosa (123386 Activities)

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Klebsiella pneumoniae (43867 Activities)

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Staphylococcus aureus (210822 Activities)

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Acinetobacter baumannii (41033 Activities)

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Escherichia coli (133304 Activities)

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Plasmodium falciparum (966862 Activities)

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Cryptococcus neoformans (21258 Activities)

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Candida albicans (78123 Activities)

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rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

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Impa1 Inositol monophosphatase 1 (16203 Activities)

Discover Target: Impa1

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Meccanismi d'azione

Proprietà chimiche e fisiche

• Sensibilità: Light sensitive
• Punto di fusione (°C): 95-98°C
• Peso molecolare: 388.500 g/mol
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 9
• Exact Mass: 388.2 Da
• Monoisotopic Mass: 388.2 Da
• Topological Polar Surface Area: 100.000 Ų
• Heavy Atom Count: 28
• Formal Charge: 0
• Complexity: 369.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 1
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

XLogP3