N-succidimidyl-S-acetyl(thiotetraethylene glycol) - ≥95% , CAS No.937025-17-7

CAS: 937025-17-7 Cat. No.: D487375 Formula: C₁₇H₂₇NO₉S Peso molecolare: 421.46

GRADE & PURITY ≥95%

Synonyms

15-Acetylthio-4,7,10,13-tetraoxa-pentadecanoic acid succinimidyl ester | 2,5-Dioxo-1-pyrrolidinyl 17-oxo-4,7,10,13-tetraoxa-16-thiaoctadecanoate | Acetyl-S-dPEG4-NHS ester | Polyethylene glycol | dPEG(R)4-SATA

Storage

Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Application

Antibody Drug Conjugates(ADC), Drug Delivery, Surface Modification, PEGylation of Protein, Peptide & Oligo

Panoramica

Features and advantages：

dPEG4-SATA (S-acetyl-dPEG4-NHS ester) contains an acetyl-protected thiol on one end of a single molecular weight dPEG linker and an amine-reactive N-hydroxysuccinimide (NHS) ester on the other end. One or more free primary amines on the target molecule can be reacted with dPEG4-SATA to install a protected thiol connected to the molecule via the dPEG linker. Three different linker lengths provide precise distance control between the target molecule and the acetyl-protected thiol group. The dPEG linker imparts water solubility and reduced immunogenicity to the target molecule. Compared to reagents containing only hydrocarbon spacers, dPEG-containing reagents also reduce aggregation and precipitation of crosslinked proteins. The acetyl group is easily removed by mild chemical deprotection with hydroxylamine hydrochloride, exposing the free thiol, which can then be used to form a disulfide or thiol ether bond to another molecule. Although commonly used with proteins, these reagents are also suitable for any small molecules or peptides with suitable functionalities.

Specifications

Sinonimi

15-Acetylthio-4,7,10,13-tetraoxa-pentadecanoic acid succinimidyl ester | 2,5-Dioxo-1-pyrrolidinyl 17-oxo-4,7,10,13-tetraoxa-16-thiaoctadecanoate | Acetyl-S-dPEG4-NHS ester | Polyethylene glycol | dPEG(R)4-SATA

Specifiche e purezza

≥95%

Condizioni di conservazione di stoccaggio

Store at -20°C,Argon charged

Spedito in

Ice chest + Ice pads

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Purezza

≥95%

Nomi e identificatori

• Sorrisi canonici: CC(=O)SCCOCCOCCOCCOCCC(=O)ON1C(=O)CCC1=O
• IUPAC Name: (2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-(2-acetylsulfanylethoxy)ethoxy]ethoxy]ethoxy]propanoate
• InChIKey: RIXCZLCOQODDNF-UHFFFAOYSA-N
• INCHI: 1S/C17H27NO9S/c1-14(19)28-13-12-26-11-10-25-9-8-24-7-6-23-5-4-17(22)27-18-15(20)2-3-16(18)21/h2-13H2,1H3
• Isomeri SMILES: CC(=O)SCCOCCOCCOCCOCCC(=O)ON1C(=O)CCC1=O
• Peso molecolare: 421.46
• Reaxy-Rn: 18838528
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=18838528&ln=