Crosslinkers

Browse crosslinkers for conjugation, immobilization, interaction studies, and structural probing. Compare linker chemistries suited to proteins, peptides, nucleic acids, and other biomolecules.

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  1. Dimethyl Pimelimidate Dihydrochloride
    CAS: 58537-94-3 PubChem CID: 11402688 Formula: C9H18N2O2·2HCl Molecular Weight: 259.17
    In Stock Item #: D155696
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    Technical Identifiers
    IUPAC Name
    dimethyl heptanediimidate;dihydrochloride
    SMILES
    COC(=N)CCCCCC(=N)OC.Cl.Cl
    InChIKey
    LRHXBHUTQWIZTN-UHFFFAOYSA-N
    InChI
    1S/C9H18N2O2.2ClH/c1-12-8(10)6-4-3-5-7-9(11)13-2;;/h10-11H,3-7H2,1-2H3;2*1H
    Synonyms
    Dimethyl pimelimidate dihydrochloride | Dimethyl pimelimidate dihydrochloride, >=99.0% (AT) | Dimethyl Pimelimidate D...
  2. DNP-PEG4-NHS ester
    CAS: 858126-78-0 Formula: C21H28N4O12 Molecular Weight: 528.47
    In Stock Item #: D336181
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    Technical Identifiers
    IUPAC Name
    (2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-(2,4-dinitroanilino)ethoxy]ethoxy]ethoxy]ethoxy]propanoate
    SMILES
    C1CC(=O)N(C1=O)OC(=O)CCOCCOCCOCCOCCNC2=C(C=C(C=C2)[N+](=O)[O-])[N+](=O)[O-]
    InChIKey
    OZBOCCBKQAMCSA-UHFFFAOYSA-N
    InChI
    1S/C21H28N4O12/c26-19-3-4-20(27)23(19)37-21(28)5-7-33-9-11-35-13-14-36-12-10-34-8-6-22-17-2-1-16(24(29)30)15-18(17)25(31)32/h1-2,15,22H,3-14H2
  3. DBCO-NHCO-PEG5-NHS ester
    CAS: 1378531-80-6 Formula: C36H43N3O11 Molecular Weight: 693.74
    In Stock Item #: D338360
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    Technical Identifiers
    IUPAC Name
    (2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-[3-[[3-(2-azatricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl)-3-oxopropyl]amino]-3-oxoproposhow more
    SMILES
    C1CC(=O)N(C1=O)OC(=O)CCOCCOCCOCCOCCOCCC(=O)NCCC(=O)N2CC3=CC=CC=C3C#CC4=CC=CC=C42
    InChIKey
    VGKLBFTYZNBCQG-UHFFFAOYSA-N
    InChI
    1S/C36H43N3O11/c40-32(37-16-13-33(41)38-27-30-7-2-1-5-28(30)9-10-29-6-3-4-8-31(29)38)14-17-45-19-21-47-23-25-49-26-24-48-22-20-46-18-15-36(44)50-39-34show more
    Synonyms
    DBCO-PEG5-NHS ester | DBCO-PEG(5)-NHS | DBCO-NH-PEG5-NHS ester
  4. Bis-PEG2-acid
    CAS: 19364-66-0 Formula: C8H14O6 Molecular Weight: 206.19
    In Stock Item #: B339051
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    Technical Identifiers
    IUPAC Name
    3-[2-(2-carboxyethoxy)ethoxy]propanoic acid
    SMILES
    C(COCCOCCC(=O)O)C(=O)O
    InChIKey
    BOXWYBCUJGWEOJ-UHFFFAOYSA-N
    InChI
    1S/C8H14O6/c9-7(10)1-3-13-5-6-14-4-2-8(11)12/h1-6H2,(H,9,10)(H,11,12)
    Synonyms
    3,3'-(ETHANE-1,2-DIYLBIS(OXY))DIPROPANOIC ACID | LCZC1128 | Bis-PEG(2)-acid | EN300-6486786 | SY272991 | 3-[2-(2-CARB...
  5. di-Boc-cystamine
    CAS: 67385-10-8 Formula: C14H28N2O4S2 Molecular Weight: 352.51
    In Stock Item #: D340481
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    Technical Identifiers
    IUPAC Name
    tert-butyl N-[2-[2-[(2-methylpropan-2-yl)oxycarbonylamino]ethyldisulfanyl]ethyl]carbamate
    SMILES
    CC(C)(C)OC(=O)NCCSSCCNC(=O)OC(C)(C)C
    InChIKey
    HBTMWZADMHBLMY-UHFFFAOYSA-N
    InChI
    1S/C14H28N2O4S2/c1-13(2,3)19-11(17)15-7-9-21-22-10-8-16-12(18)20-14(4,5)6/h7-10H2,1-6H3,(H,15,17)(H,16,18)
    Synonyms
    DTXSID00393924 | [2-(2-tert-Butoxycarbonylamino-ethyldisulfanyl)-ethyl]-carbamic acid tert-butyl ester | Di-tert-Buty...
  6. 4-(2-Chloropropionyl)phenylacetic acid
    CAS: 84098-73-7 Formula: C11H11ClO3 Molecular Weight: 226.66
    Out of Stock Item #: C332248
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    Technical Identifiers
    IUPAC Name
    2-[4-(2-chloropropanoyl)phenyl]acetic acid
    SMILES
    CC(C(=O)C1=CC=C(C=C1)CC(=O)O)Cl
    InChIKey
    SYKQUPRADSJCQY-UHFFFAOYSA-N
    InChI
    1S/C11H11ClO3/c1-7(12)11(15)9-4-2-8(3-5-9)6-10(13)14/h2-5,7H,6H2,1H3,(H,13,14)
    Synonyms
    FT-0641939 | 2-[4-(2-chloro-1-oxopropyl)phenyl]acetic acid | 2-(4-(2-Chloropropanoyl)phenyl)acetic acid | 4-(2-chloro...
  7. 3-Maleimidopropionic Acid Hydrazonium, Trifluoroacetate
    CAS: 359436-61-6 Formula: C9H10F3N3O5 Molecular Weight: 296.18
    In Stock Item #: M332246
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    Technical Identifiers
    IUPAC Name
    3-(2,5-dioxopyrrol-1-yl)propanehydrazide;2,2,2-trifluoroacetic acid
    SMILES
    C1=CC(=O)N(C1=O)CCC(=O)NN.C(=O)(C(F)(F)F)O
    InChIKey
    BADCXPKRBUEEMA-UHFFFAOYSA-N
    InChI
    1S/C7H9N3O3.C2HF3O2/c8-9-5(11)3-4-10-6(12)1-2-7(10)13;3-2(4,5)1(6)7/h1-2H,3-4,8H2,(H,9,11);(H,6,7)
    Synonyms
    3-Maleimidopropionic Acid Hydrazonium Trifluoroacetate | 3-Maleimidopropionic Acid Hydrazonium, Trifluoroacetate | 3-...
  8. Sulfo-Cy3 DBCO
    CAS: 1782950-79-1 PubChem CID: 146680152 Formula: C50H54N4O11S3 Molecular Weight: 983.18
    In Stock Item #: S335279
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    Technical Identifiers
    IUPAC Name
    2-[(E,3E)-3-[1-[6-[[3-(2-azatricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl)-3-oxopropyl]amino]-6-oxohexyl]-3,3-dimethyl-5-sulfoindoshow more
    SMILES
    CC1(C2=C(C=CC(=C2)S(=O)(=O)[O-])[N+](=C1C=CC=C3C(C4=C(N3CCCCCC(=O)NCCC(=O)N5CC6=CC=CC=C6C#CC7=CC=CC=C75)C=CC(=C4)S(=O)(=O)O)(C)C)CCCS(=O)(=O)O)C
    InChIKey
    ALLGTQOHAQKUOH-UHFFFAOYSA-N
    InChI
    1S/C50H54N4O11S3/c1-49(2)40-32-38(67(60,61)62)23-25-43(40)52(45(49)18-12-19-46-50(3,4)41-33-39(68(63,64)65)24-26-44(41)53(46)30-13-31-66(57,58)59)29-1show more
    Synonyms
    DBCO-Cy3 | DBCO-Sulfo-Cy3
  9. Biotin-PEG3-NHS ester
    CAS: 1253286-56-4 Formula: C23H36N4O9S Molecular Weight: 544.62
    In Stock Item #: B346583
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    Technical Identifiers
    IUPAC Name
    (2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]ethoxy]ethoxy]ethoxy]proshow more
    SMILES
    C1CC(=O)N(C1=O)OC(=O)CCOCCOCCOCCNC(=O)CCCCC2C3C(CS2)NC(=O)N3
    InChIKey
    QIAUJZJSFIYGMH-HOIFWPIMSA-N
    InChI
    1S/C23H36N4O9S/c28-18(4-2-1-3-17-22-16(15-37-17)25-23(32)26-22)24-8-10-34-12-14-35-13-11-33-9-7-21(31)36-27-19(29)5-6-20(27)30/h16-17,22H,1-15H2,(H,24show more
  10. α-Amine-ω-propionic acid octaethylene glycol
    CAS: 756526-04-2 Formula: C19H39NO10 Molecular Weight: 441.52
    In Stock Item #: A122172
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    Technical Identifiers
    IUPAC Name
    3-[2-[2-[2-[2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid
    SMILES
    C(COCCOCCOCCOCCOCCOCCOCCOCCN)C(=O)O
    InChIKey
    YLKOHZCQTVYVDB-UHFFFAOYSA-N
    InChI
    1S/C19H39NO10/c20-2-4-24-6-8-26-10-12-28-14-16-30-18-17-29-15-13-27-11-9-25-7-5-23-3-1-19(21)22/h1-18,20H2,(H,21,22)
    Synonyms
    Amino-PEG8-COOH | 3-[2-[2-[2-[2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoic ac...
  11. O-(2-Aminoethyl)-O′-[2-(Boc-amino)ethyl]octaethylene glycol
    CAS: 890091-43-7 Formula: C25H52N2O11 Molecular Weight: 556.69
    Out of Stock Item #: A122204
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    Technical Identifiers
    IUPAC Name
    tert-butyl N-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl]carbamate
    SMILES
    CC(C)(C)OC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN
    InChIKey
    RTTGVFBQUXJWJG-UHFFFAOYSA-N
    InChI
    1S/C25H52N2O11/c1-25(2,3)38-24(28)27-5-7-30-9-11-32-13-15-34-17-19-36-21-23-37-22-20-35-18-16-33-14-12-31-10-8-29-6-4-26/h4-23,26H2,1-3H3,(H,27,28)
    Synonyms
    Boc-PEG-amine (n=8) | AKOS040741402 | t-Boc-N-amido-PEG9-Amine | WS-01853 | Boc-N-amido-PEG9-Amine | DTXSID10405128 |...
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Frequently Asked Questions

How do I choose Crosslinkers for my workflow?
Match reactivity, spacer length, photophysical properties, and conjugation chemistry to your target. Consider water solubility, cell permeability, and downstream detection method.
What specifications matter for Crosslinkers?
Functional group reactivity, purity (HPLC), spacer length, optical properties (excitation/emission for fluorophores), water solubility, and storage stability. Light sensitivity is critical for photoactivatable compounds.
Are bifunctional and bioorthogonal variants available?
Yes. Hetero-bifunctional linkers, click chemistry reagents (azide/alkyne), and bioorthogonal handles are available for two-step labeling and conjugation workflows.
How should light-sensitive compounds be handled?
Store light-sensitive products in amber containers, protected from ambient light. Many products are stable at -20°C in the dark. Use minimal light exposure during weighing and dilution.

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