ERCC1-XPF-IN-2 - ≥98% , CAS No.1808986-37-9

CAS: 1808986-37-9 Cat. No.: E650443 Formula: C₁₅H₁₃Cl₂NO₃ Peso molecolare: 326.17

GRADE & PURITY ≥98%

Storage

Protected from light,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Panoramica

ERCC1-XPF-IN-2 is a potent ERCC1-XPF endonuclease inhibitor with an IC 50 value of 0.6 µM. ERCC1-XPF-IN-2 shows activity in nucleotide excision repair, cisplatin enhancement and γH2AX assays

In Vitro

ERCC1-XPF-IN-2 (compound 13) (0-100 µM) shows FEN-1 and DNase I activity with IC 50 s of >100, >100 µM, respectively. ERCC1-XPF-IN-2 slow binding kinetics with an K d value of ~30 µM. ERCC1-XPF-IN-2 shows not toxic to Hep-G2 cells at 10 µM and relatively short mouse and human microsomal half-lives with t 1/2 value of 23 min and 28 min for mouse and human, respectively.\nERCC1-XPF-IN-2 (0-60 µM; 24 h) shows inhibition of nucleotide excision repair (NER) with an IC 50 value of 15.6 μM in A375 cells. ERCC1-XPF-IN-2 (0-60 µM) increases the cisplatin activity with no toxicity. ERCC1-XPF-IN-2 (10 µM; 6h) causes a delay in DNA repair by a right shift towards higher numbers of γH2AX foci per cell. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Cytotoxicity AssayCell Line: A375 cells Concentration: 0-60 µM Incubation Time: Result: Showed no toxicity and increased the cisplatin activity up to 1.5-fold (PF50).

Form:Solid

IC50& Target:ERCC1-XPF

Specifications

Specifiche e purezza

≥98%

Meccanismi biochimici e fisiologici

ERCC1-XPF-IN-2 is a potent ERCC1-XPF endonuclease inhibitor with an IC 50 value of 0.6 µM. ERCC1-XPF-IN-2 shows activity in nucleotide excision repair, cisplatin enhancement and γH2AX assays.

Condizioni di conservazione di stoccaggio

Protected from light,Store at -80°C

Spedito in

Dry ice packs + Cold packs

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Tipo di azione

INHIBITOR

Purezza

≥98%

Nomi e identificatori

• Peso molecolare: 326.17

Proprietà chimiche e fisiche

• Solubilità: DMSO : ≥ 250 mg/mL (766.47 mM)

Domande frequenti

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?80 °C, protected from light. The material is light-sensitive — keep it in its original opaque or amber container.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1808986-37-9, the molecular formula is C15H13Cl2NO3, and the molecular weight is 326.17 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.