1-Cyclopropylpropan-1-amine HCl: Properties & Lab Use FAQ

1-cyclopropylpropan-1-amine hydrochloride is a stable hydrochloride salt of a primary aliphatic amine bearing a cyclopropyl substituent, widely used as a versatile building block in organic synthesis and medicinal chemistry research.

Product Name

1-Cyclopropylpropan-1-amine hydrochloride

SKU

C177155

Chemical Class

Primary aliphatic amine hydrochloride salt

Key Structural Feature

Cyclopropyl ring attached to a propan-1-amine backbone

Typical Application

Building block for medicinal chemistry and drug discovery

Physical Form

Hydrochloride salt (solid at room temperature)

What Is 1-Cyclopropylpropan-1-amine Hydrochloride?

1-Cyclopropylpropan-1-amine hydrochloride (SKU: C177155) is the hydrochloride salt of 1-cyclopropylpropan-1-amine, a primary amine in which a cyclopropyl group and an ethyl group are attached to the same carbon bearing the amino function. The cyclopropyl ring is a well-established pharmacophore that imparts conformational rigidity, modulates basicity, and can improve metabolic stability relative to open-chain alkyl analogues. Conversion to the hydrochloride salt enhances crystallinity, shelf stability, and ease of weighing compared with the free base, making it the preferred commercial form for research use.

Handling, Safety, and Storage Guidelines

As with all primary amine salts, appropriate laboratory precautions should be observed when handling 1-cyclopropylpropan-1-amine hydrochloride. Use personal protective equipment including nitrile gloves, safety glasses, and a lab coat. Work in a well-ventilated area or fume hood to minimise inhalation exposure to dust or vapours.

Store the compound in a tightly sealed container in a cool, dry place away from strong oxidising agents, acids in excess, and moisture. The hydrochloride salt form is generally more hygroscopic than neutral organic solids; desiccant storage is recommended. Always consult the current Safety Data Sheet (SDS) supplied by Aladdin Scientific before use, as it contains authoritative hazard classification, first-aid measures, and disposal guidance specific to this product.

Research and Synthetic Applications

1-Cyclopropylpropan-1-amine hydrochloride serves primarily as a versatile amine building block in medicinal chemistry and drug discovery programmes. The free base, generated in situ by treatment with a suitable base (e.g., triethylamine, potassium carbonate), can participate in a broad range of coupling reactions including reductive aminations, amide bond formations, sulfonamide preparations, and urea or carbamate syntheses.

The cyclopropyl motif is frequently incorporated into drug candidates to exploit its bioisosteric relationship with vinyl groups and its ability to influence lipophilicity (logP) and pKa relative to acyclic analogues. Researchers in fragment-based drug discovery and lead optimisation may use this compound to probe structure–activity relationships (SAR) at an amine-bearing stereocentre. The compound may also serve as a precursor in the preparation of more complex nitrogen-containing heterocyclic scaffolds.

Ordering, Availability, and Purity Specifications

1-Cyclopropylpropan-1-amine hydrochloride is available from Aladdin Scientific under SKU C177155. Researchers and procurement teams should contact Aladdin Scientific directly or visit the product page for current stock levels, available pack sizes, pricing, and purity certificate information. Certificate of Analysis (CoA) documents confirming lot-specific purity data are typically available on request or via the Aladdin website using the lot number printed on the product label.

For bulk or custom quantity enquiries, please reach out to the Aladdin Scientific sales team. Lead times, minimum order quantities, and pricing tiers for larger volumes are available upon request. Ensure that the correct SKU (C177155) is quoted in all purchase orders to avoid fulfilment errors.

Frequently Asked Questions: Quick-Reference Summary

This section consolidates the most common enquiries received from researchers and procurement professionals regarding 1-cyclopropylpropan-1-amine hydrochloride (C177155). For questions not addressed here, please contact Aladdin Scientific technical support. Detailed answers to each question are provided in the FAQ section below.

Frequently asked questions

What is the difference between 1-cyclopropylpropan-1-amine and its hydrochloride salt, and which form should I order?

The free base is a liquid or low-melting solid amine that is volatile and more susceptible to oxidation and moisture uptake, making accurate weighing difficult. The hydrochloride salt (C177155) is a crystalline solid with greater stability, easier handling, and longer shelf life under standard storage conditions. For most synthetic applications, the free base is regenerated in situ by treating the salt with an inorganic base such as potassium carbonate or an amine base such as triethylamine prior to the reaction.

How should I dissolve 1-cyclopropylpropan-1-amine hydrochloride for use in a reaction or assay?

The hydrochloride salt is generally soluble in polar protic solvents such as water, methanol, and ethanol. For organic reactions requiring the free base, dissolve the salt in a suitable aqueous or mixed solvent and treat with a stoichiometric amount of base to liberate the free amine, or use the salt directly in a reaction buffered with excess base. For biological assays, prepare stock solutions in water or DMSO according to the solubility requirements of your assay system, and verify concentration by appropriate analytical methods.

Is 1-cyclopropylpropan-1-amine hydrochloride chiral, and is an enantiopure form available?

Yes, the compound contains a stereocentre at C-1 of the propan-1-amine moiety, where the cyclopropyl group, ethyl group, amino group, and hydrogen are all distinct substituents. The racemic mixture is the standard commercial form offered as C177155. Researchers requiring enantiopure (R)- or (S)-enantiomers for SAR studies or asymmetric synthesis should contact Aladdin Scientific to enquire about custom synthesis options or alternative catalogue entries.

What are the recommended storage conditions to maintain compound integrity?

Store 1-cyclopropylpropan-1-amine hydrochloride in a tightly sealed container at room temperature or under refrigeration (2–8 °C) in a dry environment. Use desiccant packaging to protect against moisture uptake, which can accelerate degradation of amine salts. Avoid prolonged exposure to air, light, and heat. Always check the current product SDS and CoA for lot-specific recommendations.

Can this compound be used as a fragment in fragment-based drug discovery (FBDD)?

1-Cyclopropylpropan-1-amine hydrochloride can serve as a valuable amine-containing fragment for FBDD campaigns, given its low molecular weight and the pharmacophoric value of the cyclopropyl group. It can be screened directly in biophysical assays (after free-base liberation) or used as a synthetic handle to build more complex fragment libraries. Researchers should assess its physicochemical properties, including aqueous solubility and pKa, within the context of their specific fragment screening platform.

References

1. Aladdin Scientific product page for 1-cyclopropylpropan-1-amine hydrochloride, SKU C177155.
2. General reference: March, J. Advanced Organic Chemistry: Reactions, Mechanisms, and Structure. Wiley, for amide coupling and reductive amination methodology.
3. Lovering, F.; Bikker, J.; Humblet, C. Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success. J. Med. Chem. 2009, 52, 6752–6756. doi:10.1021/jm901241e
4. Talele, T. T. The 'cyclopropyl fragment' is a versatile player that frequently appears in preclinical/clinical drug molecules. J. Med. Chem. 2016, 59, 8712–8756. doi:10.1021/acs.jmedchem.6b00472

Products are supplied for research and development use only. Not for use in humans, animals, diagnosis, or therapy.