2,3,4,4-Tetrabromidiphenyl Ether: Properties & Lab Handling Guide

2,3,4,4-TetrabroModiphenyl ether is a tetrabrominated polybrominated diphenyl ether (PBDE) congener used as an analytical reference standard and research reagent in environmental chemistry, toxicology, and flame-retardant studies.

Product Name

2,3,4,4-Tetrabromidiphenyl ether

SKU

T1539666

Chemical Class

Polybrominated Diphenyl Ether (PBDE) congener

Typical Use

Analytical reference standard; environmental and toxicological research

Halogen Substitution

Four bromine atoms at positions 2, 3, 4, and 4'

Storage Recommendation

Store in a cool, dry, well-ventilated area away from light and ignition sources

Chemical Identity and Physical Properties

2,3,4,4-Tetrabromidiphenyl ether (also written as 2,3,4,4'-BDE or BDE-69 in standard PBDE nomenclature) is a halogenated aromatic ether belonging to the polybrominated diphenyl ether (PBDE) family. The molecule consists of two phenyl rings connected by an oxygen bridge, with four bromine substituents located at the 2, 3, 4, and 4' positions. This substitution pattern confers a relatively high molecular weight and lipophilicity characteristic of tetra-brominated congeners.

Key physicochemical attributes of tetra-BDE congeners as a class include low water solubility, high log K_ow values indicating strong hydrophobicity, and significant thermal stability — properties that historically made related compounds attractive as additive flame retardants in polymeric materials. The compound is supplied by Aladdin Scientific under SKU T1539666 and is intended for research use only.

Note: Specific numerical values for melting point, boiling point, and exact molecular weight are not confirmed in the current source material and should be verified against the certificate of analysis (CoA) prior to experimental use.

Research Applications

2,3,4,4-Tetrabromidiphenyl ether is primarily employed in the following research contexts:

• Environmental monitoring and analysis: PBDE congeners, including tetra-brominated variants, are persistent organic pollutants (POPs) detected in environmental matrices such as sediment, water, air, and biota. This compound serves as an authentic reference standard for method development, instrument calibration, and spike-recovery validation in gas chromatography–mass spectrometry (GC-MS) and high-resolution mass spectrometry (HRMS) workflows.
• Toxicological and mechanistic studies: Researchers investigating endocrine disruption, neurodevelopmental toxicity, and thyroid hormone interference associated with PBDE exposure use pure congener standards to establish dose–response relationships in cell-based or animal model systems.
• Flame retardant research: Material scientists and polymer chemists studying historical or emerging flame-retardant chemistries may use this compound to benchmark performance or evaluate degradation pathways.
• Metabolite and transformation product studies: The compound can serve as a parent material or reference in studies examining photolytic debromination, microbial biotransformation, and metabolic hydroxylation of PBDEs.

All applications should comply with applicable local and national regulations governing the handling and disposal of halogenated persistent organic pollutants.

Safety, Handling, and Storage Guidelines

As a brominated aromatic compound and member of a chemical class associated with environmental persistence and potential toxicity, 2,3,4,4-Tetrabromidiphenyl ether must be handled with appropriate precautions. The following guidelines apply to routine laboratory use:

Personal Protective Equipment (PPE)

• Wear chemical-resistant nitrile or neoprene gloves when handling the compound in any form.
• Use safety glasses or splash goggles to protect eyes from accidental contact.
• Work in a fume hood or well-ventilated area to minimize inhalation of vapors or particulates.
• Wear a laboratory coat and closed-toe shoes at all times.

Storage

• Store in a tightly sealed container in a cool, dry location away from direct sunlight and heat sources.
• Keep separate from oxidizing agents, strong bases, and incompatible materials.
• Adhere to local regulations for storage of halogenated organic compounds.

Waste Disposal

• Do not pour down the drain. Collect waste in labeled, chemically resistant containers.
• Dispose of as halogenated organic waste in compliance with institutional and regulatory requirements.

Important: Consult the Safety Data Sheet (SDS) specific to SKU T1539666 for complete hazard classifications, first-aid measures, and emergency response procedures before use.

Quality, Purity, and Ordering Information

Aladdin Scientific offers 2,3,4,4-Tetrabromidiphenyl ether under SKU T1539666. Researchers should note the following quality and ordering considerations:

• Purity: The purity specification for this reagent should be confirmed on the product page or certificate of analysis (CoA) prior to purchase. For quantitative analytical work, select the highest available purity grade.
• CoA and SDS: Certificates of Analysis and Safety Data Sheets are available on request or via the Aladdin Scientific product portal. Review these documents before commencing laboratory work.
• Packaging: Available pack sizes are listed on the product page; contact Aladdin Scientific customer service for bulk or custom quantity requirements.
• Regulatory compliance: As a PBDE congener, import, export, and use of this compound may be subject to national chemical control regulations. Procurement teams should verify applicable restrictions in their jurisdiction before ordering.

For ordering assistance, contact Aladdin Scientific customer service or your regional sales representative. Reference SKU T1539666 to ensure accurate fulfillment.

Frequently asked questions

What is 2,3,4,4-Tetrabromidiphenyl ether used for in research?

It is primarily used as an analytical reference standard for GC-MS and HRMS-based environmental analysis of PBDE congeners, and as a pure compound in toxicological studies investigating endocrine disruption and neurodevelopmental effects associated with PBDE exposure. It may also be used in flame-retardant research and PBDE transformation studies.

How should I store 2,3,4,4-Tetrabromidiphenyl ether (SKU T1539666)?

Store the compound in a tightly sealed container in a cool, dry, well-ventilated area away from direct sunlight, heat sources, and ignition sources. Keep it segregated from oxidizing agents and strong bases. Always consult the product-specific SDS for complete storage requirements.

Is 2,3,4,4-Tetrabromidiphenyl ether subject to regulatory restrictions?

PBDE congeners are classified as persistent organic pollutants (POPs) under international frameworks such as the Stockholm Convention, and their use, import, and export may be subject to regulatory controls that vary by jurisdiction. Researchers and procurement teams should verify applicable national and regional chemical regulations before purchasing or using this compound.

Where can I find the Certificate of Analysis (CoA) for SKU T1539666?

The Certificate of Analysis for T1539666 is available through the Aladdin Scientific product portal or can be requested from customer service. The CoA will confirm the lot-specific purity, analytical test results, and other quality parameters relevant to your application.

What personal protective equipment (PPE) should I use when handling this compound?

Use chemical-resistant nitrile or neoprene gloves, safety glasses or splash goggles, and a laboratory coat. Handle the compound in a fume hood or well-ventilated area to avoid inhalation of vapors or particulates. Consult the SDS for SKU T1539666 for full PPE and emergency response guidance.

References

1. Stockholm Convention on Persistent Organic Pollutants. United Nations Environment Programme (UNEP). Annex A, B, and C listings for polybrominated diphenyl ethers.
2. de Wit, C.A. (2002). An overview of brominated flame retardants in the environment. Chemosphere, 46(5), 583–624. doi:10.1016/S0045-6535(01)00225-9
3. Hites, R.A. (2004). Polybrominated diphenyl ethers in the environment and in people: a meta-analysis of concentrations. Environmental Science & Technology, 38(4), 945–956. doi:10.1021/es035082g

Products are supplied for research and development use only. Not for use in humans, animals, diagnosis, or therapy.