2-((4-(Carboxymethyl)phenoxy)methyl)benzoic Acid: Key FAQs

2-((4-(Carboxymethyl)phenoxy)methyl)benzoic acid is a bifunctional aromatic diacid linker compound bearing both a benzoic acid moiety and a phenoxyacetic acid moiety connected through a methylene ether bridge, making it a versatile building block for medicinal chemistry, polymer science, and supramolecular research.

CAS / SKU

C193907 (Aladdin SKU); CAS number to be confirmed from certificate of analysis

Molecular Formula

C16H14O5 (pending verification against CoA)

Functional Groups

Two carboxylic acid groups (–COOH) and one aryl ether linkage (–O–)

Key Structural Feature

Methylene ether bridge connecting an ortho-carboxyphenyl ring and a para-carboxymethylphenyl ring

Primary Research Applications

Bifunctional linker in organic synthesis, coordination chemistry, and medicinal chemistry scaffold construction

Storage Recommendation

Store in a cool, dry, well-ventilated location away from incompatible materials; confirm exact conditions on the product label

What Is 2-((4-(Carboxymethyl)phenoxy)methyl)benzoic Acid?

2-((4-(Carboxymethyl)phenoxy)methyl)benzoic acid (Aladdin SKU: C193907) is a small-molecule organic compound classified as a bifunctional aromatic diacid. Its structure consists of two aromatic rings connected by a methylene ether (–CH₂–O–) bridge: one ring carries a carboxylic acid group in the ortho position, while the second ring bears a carboxymethyl (–CH₂COOH) substituent in the para position.

This dual-carboxylic-acid architecture means the molecule presents two distinct acid functionalities with different electronic environments and steric contexts, enabling selective or orthogonal derivatization. The compound is therefore of interest as a building block in medicinal chemistry for scaffold construction, in coordination chemistry for ligand design, and in polymer chemistry as a monomer or cross-linking agent.

Purity, Specifications, and Quality

Aladdin Scientific supplies 2-((4-(Carboxymethyl)phenoxy)methyl)benzoic acid (C193907) as a research-grade reagent. Exact purity specifications, analytical data (such as HPLC purity, melting point, and NMR confirmation), and lot-specific certificates of analysis (CoA) are available upon request or can be downloaded from the Aladdin Scientific product page.

Researchers requiring high-purity material for sensitive assays—such as biological screening or quantitative structure–activity relationship (QSAR) studies—are advised to review the CoA for each lot before use. If a particular purity grade or custom quantity is required, please contact Aladdin Scientific's technical sales team to discuss options.

Note: Specific purity values are not reproduced here to avoid discrepancy with lot-specific data; always refer to the current CoA.

Handling, Safety, and Storage Guidelines

As with all research chemicals containing free carboxylic acid groups, standard laboratory precautions should be observed when handling 2-((4-(Carboxymethyl)phenoxy)methyl)benzoic acid. Researchers should consult the Safety Data Sheet (SDS) provided by Aladdin Scientific before first use.

General guidelines include: wear appropriate personal protective equipment (PPE) including nitrile gloves, safety glasses, and a laboratory coat; avoid inhalation of dust or aerosols; and work in a well-ventilated fume hood when weighing or dissolving the compound. In case of skin or eye contact, rinse immediately with copious amounts of water and seek medical advice if irritation persists.

For storage, keep the compound in a tightly sealed container in a cool, dry, and well-ventilated area, away from strong oxidising agents and bases. Refer to the product label and SDS for confirmed storage temperature and shelf-life information, as lot-specific conditions may apply.

Common Research Applications

The bifunctional diacid structure of 2-((4-(Carboxymethyl)phenoxy)methyl)benzoic acid lends itself to several categories of research application:

• Medicinal Chemistry: The compound can serve as a dipodal scaffold for constructing molecules that simultaneously engage two binding sites, or as an intermediate in the synthesis of more complex pharmacophores.
• Coordination Chemistry and Metal–Organic Frameworks (MOFs): Diacid linkers with mixed aromatic environments are commonly employed to construct porous coordination polymers and MOFs with tunable topology and porosity.
• Polymer Science: The two carboxylic acid groups can participate in condensation polymerisation reactions (e.g., polyester or polyamide formation), introducing a flexible ether linkage into the polymer backbone.
• Supramolecular Chemistry: The compound's geometry and hydrogen-bonding capacity make it a candidate building block for self-assembled supramolecular architectures.

Researchers are encouraged to consult primary literature for specific protocols; Aladdin Scientific can advise on suitable grades for particular applications.

Ordering, Availability, and Customer Support

2-((4-(Carboxymethyl)phenoxy)methyl)benzoic acid is available from Aladdin Scientific under SKU C193907. To place an order, visit the Aladdin Scientific website and search by product name or SKU, or contact the customer service team directly for bulk quantities, custom packaging, or expedited delivery enquiries.

For technical questions regarding purity suitability for a specific assay, compatibility with particular solvents, or scale-up requirements, Aladdin Scientific's technical support team is available via the website's enquiry form or by telephone during business hours. Certificate of Analysis and Safety Data Sheet documents are available for download on the product page or upon request.

For questions about pricing, promotions, or institutional purchase orders, please refer to the Aladdin Scientific ordering and payment FAQ pages, or contact the sales team directly.

Frequently asked questions

What is the molecular structure of 2-((4-(Carboxymethyl)phenoxy)methyl)benzoic acid?

The compound contains two phenyl rings connected by a –CH2–O– (methylene ether) bridge. One ring bears a carboxylic acid (–COOH) group at the ortho position; the other bears a carboxymethyl (–CH2COOH) group at the para position. This arrangement provides two chemically distinct carboxylic acid handles within a single rigid-flexible hybrid scaffold.

What solvents are typically used to dissolve this compound?

Aromatic diacids of this structural class are generally soluble in polar aprotic solvents such as dimethyl sulfoxide (DMSO) and dimethylformamide (DMF), and in aqueous base (due to carboxylate salt formation). Solubility in common organic solvents such as ethanol or acetone may be moderate. Researchers should perform a small-scale solubility test and consult the SDS; Aladdin Scientific's technical team can provide further guidance.

How should I store 2-((4-(Carboxymethyl)phenoxy)methyl)benzoic acid to maintain its stability?

Store the compound in a tightly sealed container under cool, dry, and well-ventilated conditions, protected from moisture and light. Avoid contact with strong oxidising agents or strong bases. Always refer to the specific storage conditions stated on the product label and the current Safety Data Sheet (SDS) supplied with the product, as lot-specific recommendations may differ.

Can this compound be used as a linker in metal–organic framework (MOF) synthesis?

The dual carboxylic acid groups and mixed-rigidity architecture of this compound make it a structurally interesting candidate for MOF ligand design. Diacid linkers with ether spacers have been explored in coordination polymer synthesis to tune pore geometry and flexibility. However, its specific performance in MOF synthesis would need to be validated experimentally; Aladdin Scientific recommends consulting relevant primary literature for suitable synthesis protocols.

How do I obtain a Certificate of Analysis (CoA) or Safety Data Sheet (SDS) for C193907?

The Certificate of Analysis and Safety Data Sheet for C193907 can be downloaded directly from the product page on the Aladdin Scientific website by searching for the SKU or product name. If you require a lot-specific CoA or cannot locate the document online, please contact Aladdin Scientific customer service with your lot number and order details.

References

1. Aladdin Scientific product page for 2-((4-(Carboxymethyl)phenoxy)methyl)benzoic acid, SKU C193907. Retrieved from Aladdin Scientific official website.
2. General reference: March, J. Advanced Organic Chemistry: Reactions, Mechanisms, and Structure. Wiley-Interscience. (Textbook-level background on aromatic carboxylic acids and ether chemistry.)
3. Yaghi, O. M. et al. Reticular synthesis and the design of new materials. Nature, 423, 705–714 (2003). (Background on diacid linkers in MOF design; applicability to this specific compound requires verification.) doi:10.1038/nature01650

Products are supplied for research and development use only. Not for use in humans, animals, diagnosis, or therapy.