6-Methoxy-2-methylpyrimidin-4-amine: Properties & Lab FAQ

6-Methoxy-2-methylpyrimidin-4-amine is a substituted aminopyrimidine building block widely used in medicinal chemistry and heterocyclic synthesis research.

Product Name

6-Methoxy-2-methylpyrimidin-4-amine

SKU

M691945

Molecular Formula

C6H9N3O

Core Structure

Pyrimidine ring with methoxy at C-6, methyl at C-2, and amino group at C-4

Compound Class

Aminopyrimidine heterocycle

Primary Application

Synthetic building block for medicinal chemistry and agrochemical research

Chemical Identity and Structure

6-Methoxy-2-methylpyrimidin-4-amine (SKU: M691945) is a six-membered nitrogen-containing heterocycle belonging to the pyrimidine family. The compound features three key substituents on the pyrimidine ring: an amino group (–NH2) at the 4-position, a methoxy group (–OCH3) at the 6-position, and a methyl group (–CH3) at the 2-position. Its molecular formula is C6H9N3O, and it is also commonly referred to as 4-amino-6-methoxy-2-methylpyrimidine in the literature.

The presence of both a primary amine and a methoxy group on the electron-deficient pyrimidine scaffold makes this compound a versatile intermediate capable of undergoing nucleophilic substitution, condensation, and cross-coupling reactions, which are extensively exploited in the synthesis of pharmacologically active molecules.

Handling, Solubility, and Storage

As with most heterocyclic amines, 6-Methoxy-2-methylpyrimidin-4-amine should be handled with standard laboratory precautions: wear appropriate personal protective equipment including gloves, safety glasses, and a lab coat. Work in a well-ventilated area or fume hood when weighing or preparing solutions.

The compound is expected to show moderate solubility in polar organic solvents such as dimethyl sulfoxide (DMSO), dimethylformamide (DMF), and ethanol, while exhibiting limited solubility in non-polar solvents such as hexane or diethyl ether. For aqueous applications, solubility may be enhanced under mildly acidic conditions due to protonation of the amino group.

For long-term storage, keep the material in a tightly sealed container away from light, heat, and moisture, at room temperature or under refrigeration (2–8 °C) as indicated on the product label. Always verify storage conditions on the current Certificate of Analysis (CoA) supplied with your lot.

Applications in Research and Synthesis

6-Methoxy-2-methylpyrimidin-4-amine serves primarily as a synthetic building block in medicinal chemistry, agrochemical research, and materials science. The aminopyrimidine motif is a privileged scaffold found in numerous biologically active compounds, including kinase inhibitors, antiviral agents, and herbicides.

Researchers use this compound as a starting material or intermediate for constructing more complex heterocyclic architectures. The amino group at C-4 can be acylated, sulfonylated, or engaged in reductive amination, while the methoxy group at C-6 is susceptible to nucleophilic displacement, enabling introduction of diverse nitrogen, oxygen, or carbon nucleophiles. These orthogonal handles provide significant synthetic flexibility.

Ordering and Quality Information

6-Methoxy-2-methylpyrimidin-4-amine is available from Aladdin Scientific under SKU M691945. When placing an order, please reference this SKU to ensure you receive the correct material. Aladdin Scientific provides a Certificate of Analysis (CoA) with each lot, detailing purity, appearance, and analytical data such as NMR or HPLC results where applicable.

For bulk quantities, custom packaging, or specific purity grades, please contact Aladdin Scientific's technical sales team. Procurement managers should verify current pricing, availability, and lead times directly through the Aladdin Scientific website or by contacting customer service.

Frequently asked questions

What is 6-Methoxy-2-methylpyrimidin-4-amine used for in research?

6-Methoxy-2-methylpyrimidin-4-amine is primarily used as a synthetic building block in medicinal chemistry and agrochemical research. Its aminopyrimidine scaffold serves as a key intermediate for the preparation of kinase inhibitors, heterocyclic drug candidates, and other biologically active molecules. The compound's reactive amino and methoxy groups allow diverse chemical transformations.

What solvents are suitable for dissolving 6-Methoxy-2-methylpyrimidin-4-amine?

6-Methoxy-2-methylpyrimidin-4-amine is expected to dissolve well in polar organic solvents such as DMSO, DMF, and ethanol. Solubility in water is limited but may be improved under mildly acidic conditions. Non-polar solvents such as hexane are generally not suitable. Always perform a preliminary solubility test for your specific application and concentration requirements.

How should 6-Methoxy-2-methylpyrimidin-4-amine be stored to maintain stability?

The compound should be stored in a tightly sealed container, protected from light, moisture, and heat. Storage at room temperature or under refrigeration (2–8 °C) is generally recommended for aminopyrimidine compounds. Always consult the lot-specific Certificate of Analysis from Aladdin Scientific for confirmed storage conditions.

What is the SKU for 6-Methoxy-2-methylpyrimidin-4-amine at Aladdin Scientific?

The SKU for 6-Methoxy-2-methylpyrimidin-4-amine at Aladdin Scientific is M691945. Please use this SKU when placing orders or making inquiries to ensure accurate product identification.

What safety precautions should be taken when handling this compound?

Standard laboratory precautions apply: wear nitrile gloves, safety glasses, and a lab coat. Handle the compound in a well-ventilated area or fume hood. Consult the Safety Data Sheet (SDS) provided by Aladdin Scientific for comprehensive hazard information, first-aid measures, and disposal guidelines specific to this material.

References

1. Joule, J. A.; Mills, K. Heterocyclic Chemistry, 5th ed.; Wiley-Blackwell: Oxford, 2010. General reference for pyrimidine chemistry and reactivity.
2. Aladdin Scientific Product Page: 6-Methoxy-2-methylpyrimidin-4-amine, SKU M691945.

Products are supplied for research and development use only. Not for use in humans, animals, diagnosis, or therapy.