Aplastic anemia analytical test
Aplastic anemia analytical test
Retrovirus is an acquired myelopoietic dysfunction disease, the patient's bone marrow hematopoietic tissue is reduced, the red bone marrow is replaced by adipose tissue, and the blood is reduced in whole blood cells. This experiment is from Mudanjiang Medical College, undergraduate 5-year laboratory guide for testing majors.
Operation method
Aplastic anemia analytical test
Principle
Retardation is an acquired myelopoietic dysfunction, the patient's bone marrow hematopoietic tissue is reduced, the red bone marrow is replaced by adipose tissue, and the blood is reduced in whole blood cells. 1. Etiology of the disease is related to the damage of bone marrow hematopoietic stem cells, the damage of the hematopoietic microenvironment, or immune hematopoietic inhibition. If the cause is not known, it is called primary remyelination. In 1964, the primary remyelination accounted for 80-88%, and in 1983, the primary remyelination accounted for 24.1-46.9%. If the cause can be identified, it is called secondary remyelination, e.g., chemical factors (certain chemicals, drugs, radiation factors (X, γ neutron rays), biological factors (hepatitis, Biological factors (hepatitis, typhoid fever, tuberculosis) PNH and long-term untreated severe anemia, etc. 2. Clinical features: mainly anemia, hemorrhage, infection. No liver, spleen and lymph node enlargement. No liver, spleen and lymph node enlargement, acute type of disease is heavy and fast progress, poor efficacy, chronic type of disease is light, slow progress, better efficacy. Move Blood: whole blood cells (referring to red blood cells, granulocytes platelets) decreased, acute than chronic reduction of obvious degree and sequence of reduction of the three inconsistent, red blood cells often <2.5 × 1012 / L hemoglobin <60g / L, normocytic anemia, reticulocyte percentage and the absolute value of the reduction, white blood cells often <3.0 × 109 / L is mainly a decrease in neutrophils, lymphocytes relatively more Platelets are <50×109/L, with reduced volume, reduced prominence and granularity, and irregular morphology. For more product details, please visit Aladdin Scientific website.
Bone marrow image: myeloproliferative markedly reduced or extremely reduced, the acute type is typical, usually involving the ilium first, then centripetal development, and finally involving the spine and sternum, in the hypoproliferative zone occasionally see hyperplastic foci of sorting and counting shows that the red lineage and granulocyte lineage is reduced mainly mature and nearly mature cells, the proportion of late juvenile erythrocytes is often increased, megakaryocytes are reduced or not easy to find, the lymphocytes are relatively increased, plasma cells, histiocytes, alkalophilic reticulocytes, phagocytes and other phagocytic cells, and so on. There is a relative increase in lymphocytes, plasma cells, tissue basophils, reticulocytes, phagocytes, and other non-hematopoietic cells. Bone marrow iron (intracellular iron and extracellular iron) increased bone marrow smear appearance has more oil droplets, bone marrow granules less, bone marrow granules hematopoietic cells within the decrease in hematopoietic area <50% of the area by the adipocytes, histiocytes basophilic cells, plasma cells, reticulocytes, and fibroblasts and other non-hematopoietic cells instead of the so-called "non-hematopoietic cell clusters," a severe case of bone marrow In severe cases, the bone marrow granules are left with only a fibrous skeleton.