Chrysophanol 8-O-glucoside: Properties, Uses & FAQs

Chrysophanol 8-O-glucoside is a naturally occurring anthraquinone glycoside in which the aglycone chrysophanol is linked to a glucose moiety at the 8-position, and it is supplied by Aladdin Scientific (SKU C649519) as a high-purity reference standard for pharmacological and phytochemical research.

Product SKU

C649519

Also Known As / Reference ID

HY-N2395 (MCE cross-reference)

Compound Class

Anthraquinone O-glycoside (natural product)

Aglycone

Chrysophanol (1,8-dihydroxy-3-methylanthraquinone)

Glycosylation Site

8-OH position of the anthraquinone scaffold

Sugar Moiety

D-Glucose

Typical Application

Phytochemical research, bioactivity studies, HPLC reference standard

What Is Chrysophanol 8-O-glucoside?

Chrysophanol 8-O-glucoside is a naturally occurring anthraquinone glycoside found in various medicinal plants, including species in the genera Rheum and Rumex. The compound consists of the anthraquinone aglycone chrysophanol (1,8-dihydroxy-3-methylanthraquinone) with a glucose unit attached via an O-glycosidic bond at the C-8 hydroxyl position.

As a glycosylated form of chrysophanol, this compound typically exhibits altered solubility and bioavailability relative to the free aglycone. It is isolated from plant material and supplied as a purified reference standard suitable for use in phytochemical profiling, pharmacokinetic studies, and bioassay development.

Purity, Grade, and Quality Specifications

Aladdin Scientific supplies Chrysophanol 8-O-glucoside (SKU C649519) as a research-grade reference standard. Customers requiring precise purity data, such as HPLC purity percentage, specific optical rotation, and water content, should consult the Certificate of Analysis (CoA) issued with each specific lot.

When evaluating reagent suitability, researchers should confirm: (1) HPLC purity is appropriate for the intended assay sensitivity; (2) the compound identity has been verified by NMR or MS; and (3) the lot-specific CoA is retained for experimental records. Contact Aladdin Scientific's technical support team to request a CoA for a specific lot number prior to purchase if required.

Solubility and Storage Guidelines

As an anthraquinone O-glucoside, Chrysophanol 8-O-glucoside is generally more water-soluble than its aglycone chrysophanol due to the hydrophilic glucose moiety. It is commonly dissolved in dimethyl sulfoxide (DMSO) to prepare stock solutions for biological assays; aqueous buffer solubility depends on pH and concentration and should be verified experimentally for each application.

General storage recommendations for anthraquinone glycoside reference standards include: storage at −20 °C or as specified on the product label, protection from light due to photosensitivity of the anthraquinone chromophore, and use of desiccated conditions to prevent moisture uptake. Always refer to the product label and CoA for lot-specific storage instructions. Avoid repeated freeze-thaw cycles to maintain compound integrity.

Research Applications

Chrysophanol 8-O-glucoside is used primarily as an analytical reference standard and research tool in the following contexts:

• Phytochemical profiling: HPLC and LC-MS quantification of anthraquinone glycosides in herbal extracts and traditional medicine preparations.
• Pharmacokinetic studies: Investigation of absorption, distribution, metabolism, and excretion (ADME) of anthraquinone glycosides following oral administration.
• Bioactivity screening: In vitro evaluation of potential anti-inflammatory, antioxidant, or other biological activities, consistent with research conducted on structurally related anthraquinone glycosides.
• Method validation: Use as a certified or characterised reference material for validating analytical methods in food safety and herbal medicine quality control laboratories.

Researchers should conduct independent validation of any bioactivity data for their specific experimental systems.

Ordering, Handling, and Regulatory Information

Ordering: Chrysophanol 8-O-glucoside is available from Aladdin Scientific under SKU C649519. To place an order, contact your regional Aladdin Scientific sales representative, use the online portal, or submit a purchase order referencing the SKU. For bulk quantities or custom packaging, please contact technical sales.

Handling precautions: Handle as a research chemical following standard laboratory safety practices. Wear appropriate personal protective equipment (PPE) including gloves and safety glasses. Consult the Safety Data Sheet (SDS) before use. Anthraquinone derivatives may cause skin and eye irritation; avoid inhalation of dust or aerosols.

Regulatory: This product is supplied for research use only (RUO) and is not approved for human or veterinary diagnostic or therapeutic use. Export may be subject to local regulations; purchasers are responsible for compliance.

Frequently asked questions

What is the catalog number for Chrysophanol 8-O-glucoside at Aladdin Scientific?

Chrysophanol 8-O-glucoside is listed under SKU C649519 at Aladdin Scientific. It is also cross-referenced with MCE catalog number HY-N2395. Please quote SKU C649519 when placing your order.

What solvents are recommended for dissolving Chrysophanol 8-O-glucoside?

DMSO is commonly used to prepare stock solutions of anthraquinone glycosides for biological assays, as it offers good solubility for this compound class. Solubility in aqueous buffers is generally higher than for the free aglycone due to the glucose moiety, but should be verified experimentally for each application and concentration. Always consult the product CoA and SDS for specific guidance.

How should Chrysophanol 8-O-glucoside be stored to maintain stability?

As an anthraquinone glycoside, this compound should generally be stored at −20 °C, protected from light, and kept under dry conditions to prevent degradation and moisture uptake. Repeated freeze-thaw cycles should be avoided. Please refer to the specific storage instructions printed on the product label and the lot CoA, as these take precedence.

What analytical methods are suitable for verifying the identity and purity of Chrysophanol 8-O-glucoside?

HPLC with UV detection (typically monitoring the anthraquinone chromophore around 254–430 nm) is the standard method for purity assessment of anthraquinone glycosides. Compound identity can be confirmed by LC-MS (molecular ion verification) and NMR spectroscopy (structural assignment). The lot-specific CoA from Aladdin Scientific will state the analytical methods and purity results used for batch release.

Is Chrysophanol 8-O-glucoside approved for therapeutic or diagnostic use in humans?

No. Chrysophanol 8-O-glucoside (SKU C649519) is supplied by Aladdin Scientific strictly for research use only (RUO). It has not been approved by any regulatory authority for therapeutic, diagnostic, or veterinary use. It must not be administered to humans or animals.

References

1. MedChemExpress (MCE) product page for Chrysophanol 8-O-glucoside, HY-N2395. Retrieved from MedChemExpress catalog.
2. General reference: Anthraquinone glycosides in Rheum and Rumex species — phytochemistry and biological activities. [Specific citation needed; textbook-level background claim.]
3. Chrysophanol (aglycone) phytochemistry and pharmacology: general textbook reference for anthraquinone scaffold properties. [Specific citation needed.]

Products are supplied for research and development use only. Not for use in humans, animals, diagnosis, or therapy.