Methyl 4-(2-methoxyphenyl)-2,4-dioxobutanoate: FAQs

Methyl 4-(2-methoxyphenyl)-2,4-dioxobutanoate is a bifunctional 1,3-diketone ester building block bearing both an aryl ketone and a methyl ester group, making it a versatile intermediate for heterocyclic synthesis and medicinal chemistry research.

CAS Number

To be confirmed — see product datasheet (review flag)

Molecular Formula

C12H12O5 (textbook-level assignment; verify against CoA)

Functional Groups

Aryl ketone, methyl ester, alpha-diketone motif (1,3-dioxo system)

Key Application

Heterocyclic synthesis intermediate; potential scaffold for medicinal chemistry

SKU

M700692

Supplier

Aladdin Scientific

What Is Methyl 4-(2-methoxyphenyl)-2,4-dioxobutanoate?

Methyl 4-(2-methoxyphenyl)-2,4-dioxobutanoate is an organic compound characterised by a 1,3-dioxobutanoate backbone substituted at the 4-position with a 2-methoxyphenyl (o-anisyl) carbonyl group and at the 1-position with a methyl ester. The compound belongs to the class of beta-ketoesters and 1,3-diketones, a structural motif widely exploited in synthetic organic chemistry for the construction of five- and six-membered heterocyclic rings through condensation reactions with dinucleophiles such as hydrazines, amidines, and ureas.

The 2-methoxyphenyl substituent introduces steric and electronic effects that can influence reaction selectivity and the physicochemical properties of derived products, including potential intramolecular hydrogen bonding and restricted rotation about the aryl–carbonyl bond.

Handling, Safety and Storage

As with most beta-ketoester compounds, Methyl 4-(2-methoxyphenyl)-2,4-dioxobutanoate should be handled using standard laboratory safety precautions. Researchers should wear appropriate personal protective equipment, including nitrile gloves, safety glasses, and a lab coat, and work in a well-ventilated fume hood.

For storage, the compound should be kept in a tightly sealed container away from moisture, heat, and strong oxidising agents. Cool, dry conditions (typically 2–8 °C or as specified on the product Certificate of Analysis) are recommended to preserve reagent integrity. Always consult the Safety Data Sheet (SDS) provided by Aladdin Scientific for compound-specific hazard classifications and first-aid measures before use.

Note: Specific GHS hazard classifications and recommended storage temperatures should be verified against the official Aladdin Scientific SDS for SKU M700692.

Purity, Specifications and Quality

Aladdin Scientific supplies Methyl 4-(2-methoxyphenyl)-2,4-dioxobutanoate under SKU M700692. Purity specifications and analytical data, including HPLC purity, NMR characterisation, and appearance, are detailed in the Certificate of Analysis (CoA) available for each production lot.

Researchers requiring high-purity material for sensitive applications such as asymmetric synthesis or biological assays should request the relevant CoA at the time of ordering to confirm the specific lot purity meets experimental requirements. Contact Aladdin Scientific technical support if custom purity grades or larger pack sizes are needed.

Typical Applications in Research

Methyl 4-(2-methoxyphenyl)-2,4-dioxobutanoate serves primarily as a synthetic building block in the preparation of heterocyclic compounds. The active methylene and dual carbonyl functionality make it receptive to a range of condensation reactions:

• Pyrazole synthesis: Reaction with monosubstituted or disubstituted hydrazines yields pyrazole or dihydropyrazole derivatives, useful scaffolds in medicinal chemistry.
• Pyrimidine synthesis: Condensation with amidines or guanidines can afford aminopyrimidine frameworks.
• Enol chemistry: The compound may exist partially in enol form, enabling chelation with metal ions relevant to coordination chemistry studies.

The ortho-methoxy group on the phenyl ring may be leveraged for further functionalisation or to modulate the pharmacophoric properties of final products. Specific literature references for these transformations should be identified and cited in any downstream publication.

Ordering and Customer Support

Methyl 4-(2-methoxyphenyl)-2,4-dioxobutanoate is available from Aladdin Scientific under SKU M700692. To place an order, visit the Aladdin Scientific website and search by product name or SKU, or contact your regional sales representative.

For technical enquiries regarding purity, compatibility, custom synthesis, or bulk pricing, please reach out to Aladdin Scientific's technical support team. Certificate of Analysis documents for specific lot numbers can be requested via the website or customer service channels. Information on shipping conditions, return policies, and payment options is available in the Help & Customer Service section of the Aladdin Scientific website.

Frequently asked questions

What is the molecular structure of Methyl 4-(2-methoxyphenyl)-2,4-dioxobutanoate?

The compound features a four-carbon 1,3-dioxobutanoate chain with a methyl ester at C-1 and a 2-methoxyphenyl ketone carbonyl at C-4, creating a 1,3-diketone (beta-ketoester) system. This architecture supports keto-enol tautomerism and makes the compound highly reactive towards dinucleophilic cyclisation partners. The exact molecular formula and molecular weight should be confirmed via the Aladdin Scientific product datasheet or Certificate of Analysis for SKU M700692.

How should Methyl 4-(2-methoxyphenyl)-2,4-dioxobutanoate be stored to maintain stability?

The reagent should be stored in a tightly sealed container under cool, dry conditions, away from moisture, light, and strong oxidising agents. Refrigerated storage (2–8 °C) is generally advisable for beta-ketoester compounds to minimise decomposition, but the precise recommended storage temperature for this specific compound should be confirmed by consulting the Aladdin Scientific SDS and CoA for SKU M700692. Always bring the container to room temperature before opening to avoid condensation contamination.

What are the main synthetic uses of Methyl 4-(2-methoxyphenyl)-2,4-dioxobutanoate in the laboratory?

This compound is primarily used as a building block for the synthesis of heterocyclic scaffolds, including pyrazoles and pyrimidines, via condensation with hydrazines or amidines respectively. The 1,3-diketone motif also makes it suitable for chelation studies in coordination chemistry. Researchers in medicinal chemistry value the 2-methoxyphenyl group for its potential to confer specific steric and electronic properties to the resulting heterocyclic products.

How can I obtain a Certificate of Analysis (CoA) for a specific lot of M700692?

Certificates of Analysis for Aladdin Scientific products, including SKU M700692, can be requested through the Aladdin Scientific website by entering the product SKU and lot number, or by contacting the customer service team directly. It is recommended to request the CoA before or at the time of ordering to confirm that the lot purity and specifications meet your experimental requirements.

Is Methyl 4-(2-methoxyphenyl)-2,4-dioxobutanoate available in bulk or custom quantities?

Aladdin Scientific offers a range of pack sizes for research reagents, and bulk or custom quantity enquiries for SKU M700692 can be directed to the Aladdin Scientific sales or technical support team. Custom purity grades or formulations may also be available upon request. Contact Aladdin Scientific directly for pricing and lead-time information for non-standard quantities.

References

1. Aladdin Scientific product page for Methyl 4-(2-methoxyphenyl)-2,4-dioxobutanoate, SKU M700692. Aladdin Scientific.
2. March, J. Advanced Organic Chemistry: Reactions, Mechanisms, and Structure. Wiley. (General reference for 1,3-diketone and beta-ketoester chemistry.)
3. Clayden, J.; Greeves, N.; Warren, S. Organic Chemistry. Oxford University Press. (Reference for keto-enol tautomerism and heterocycle synthesis from 1,3-dicarbonyl compounds.)

Products are supplied for research and development use only. Not for use in humans, animals, diagnosis, or therapy.