Hepatitis B Animal Model
Chronic hepatitis B (CHB) caused by hepatitis B virus (HBV) infection and associated liver cirrhosis (L.C). Hepatocellular carcinoma (HCC) and liver failure are
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3228 articles
Animal model of urethral hypospadias
Hypospadias is a urethral malformation in which the opening of the urethra fails to reach its normal position due to abnormal development of the anterior urethr
Mouse Chromosome Recombination Technology
Homologous recombination is a type of genetic recombination, which refers to the rearrangement of DNA caused by the exchange of nucleic acid sequences between t
RNA interference-based knockdown technology in animals
RNAi is a type of gene silencing that occurs through in vivo shearing to form small (~21 nt) double-stranded RNAs in which the antisense strand is complementary
Bacterial artificial chromosome transgenic animal technology
Bacterial artificial chromosomes (BAC) are vector systems that allow the cloning of large segments of exogenous DNA. It consists mainly of a replicon composed o
Animal model of Acinetobacter baumannii infection
Acinetolacter baumannii is a gram-negative bacillus that does not ferment sugars, and is widely distributed in nature. Hospitals and human skin, belonging to th
Preparation of transgenic animals by infection with recombinant retroviral (lentiviral) vectors
Lentiviral vector is a new type of transgenic vector developed in recent years. Lentiviruses belong to the subfamily of retroviruses. After structural modificat
CRISPR/Cas9 system-based gene knockout technology in animals
CRISPR/Cas (clustered regularly interspaced short palindromic repeats/CRISPR-associated system) is present in most bacteria and almost all archaea, and is an im
Knockout technology based on homologous recombination of embryonic stem cells
Homologous recombination is a type of genetic recombination, which refers to the rearrangement of DNA caused by the exchange of nucleic acid sequences between t