Experimental measurement of pharmacokinetic parameters of sulfonamides
Sulfonamides can react with certain reagents to form colored substances, and their blood concentrations can be quantified by colorimetry. In acidic environments
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Tests for syrup preparations
Syrup (Appendix I K of Part II of the 2010 edition of the Chinese Pharmacopoeia) refers to a concentrated aqueous sucrose solution containing the drug for oral
Experimental effects of sodium phenobarbital and actinomycin D on cytochrome P-450 content in mouse liver
P-450 belongs to hemoglobin protein, and its reduced form combines with CO and shows an absorption peak at 450 nm. Therefore, the content of P-450 can be determ
Detergents, rinses, and enemas screening tests
Lotion (Chinese Pharmacopoeia, 2010 Edition, Part II, Appendix I S) means a solution, emulsion, or suspension containing a drug for cleansing or applying to unb
Applying, coating, filming agent inspection test
Application (Appendix I T of Part II of the 2010 edition of the Chinese Pharmacopoeia) refers to liquid preparations containing a solution, emulsion or suspensi
Experimental action of prazosin on isolated vascular smooth muscle
The rabbit isolated aortic strip assay can be used to observe the effects of drugs on the diastolic and contractile functions of vascular smooth muscle. Observa
Analytical experiments on the mechanism of action of unknown antihypertensive drugs
Ganglion blockers affect the blood pressure drop induced by direct stimulation of the vagus nerve and the boosting effect of clamping the common carotid artery,
Experimental prevention of barium chloride-induced arrhythmias by propranolol and quinidine
Barium chloride induces arrhythmias by increasing the inward Na+ current in Purkinje fibers and increasing the depolarization rate of the maximal diastolic pote
Experiments on the effect of different routes of administration on drug action
In pharmacology experiments, there are many factors affecting the experimental results, some of which can be controlled, while some are difficult to control. In