Drug synthesis

Amino groups, amino alcohols, vicinal diamines, and saturated nitrogen-containing heterocycles are widely found in drug molecules and their synthetic intermediates. The synthesis of these structures requires not only the introduction of nitrogen atoms, but also control over the position of ...

Converting aldehydes/ketones into amines is one of the most common C–N bond-forming approaches in pharmaceutical synthesis, monomer modification for materials, and fine chemical manufacturing. Reductive amination is popular largely because it can often be done “one-pot”: the carbonyl and ...