Gentamicin - Moligand™, ≥900IU/mg (Microbiological assay of antibiotics, Dried Basis) , Gating inhibitor of TRPA1;Inhibitor of TRPV5, CAS No.1403-66-3, Gating inhibitor of TRPA1;Inhibitor of TRPV5

CAS: 1403-66-3 Cat. No.: G302822 Numero EC: 215-765-8

GRADE & PURITY Moligand™, ≥900IU/mg (Microbiological assay of antibiotics, Dried Basis)

Synonyms

Gentamicina | Gentamicine (INN-French) | Lyramycin | STL454325 | Gentamicins | GENTAMYCIN | Gentamicin (TN) | Genoptic S.O.P. | gentamicin | Gentamicinum [INN-Latin] | Gentamycin C1 | 1294497-75-8 | SCHEMBL537630 | AC-13386 | Centicin | HSDB 3087 | Refoba

Storage

Protected from light,Store at -20°C,Argon charged,Desiccated

Shipped In

Ice chest + Ice pads

Panoramica

Gentamicin is a Aminoglycoside with oral activity, which can inhibit the growth of Gram-positive bacteria and gram-negative bacteria and inhibit many mycoplasma strains in tissue culture. The IC50 value of Gentamicin inhibiting DNase I activity is 0.57 mM.

Specifications

Sinonimi

Gentamicina | Gentamicine (INN-French) | Lyramycin | STL454325 | Gentamicins | GENTAMYCIN | Gentamicin (TN) | Genoptic S.O.P. | gentamicin | Gentamicinum [INN-Latin] | Gentamycin C1 | 1294497-75-8 | SCHEMBL537630 | AC-13386 | Centicin | HSDB 3087 | Refoba

Specifiche e purezza

Moligand™, ≥900IU/mg (Microbiological assay of antibiotics, Dried Basis)

Condizioni di conservazione di stoccaggio

Protected from light,Store at -20°C,Argon charged,Desiccated

Spedito in

Ice chest + Ice pads

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Grado

Moligand™

Tipo di azione

GATING INHIBITOR, INHIBITOR

Meccanismo d'azione

Gating inhibitor of TRPA1;Inhibitor of TRPV5

Nomi e identificatori

Pubchem Sid

504750674

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/504750674

Sorrisi canonici

CC(C1CCC(C(O1)OC2C(CC(C(C2O)OC3C(C(C(CO3)(C)O)NC)O)N)N)N)NC

IUPAC Name

2-[4,6-diamino-3-[3-amino-6-[1-(methylamino)ethyl]oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol

InChIKey

CEAZRRDELHUEMR-UHFFFAOYSA-N

INCHI

1S/C21H43N5O7/c1-9(25-3)13-6-5-10(22)19(31-13)32-16-11(23)7-12(24)17(14(16)27)33-20-15(28)18(26-4)21(2,29)8-30-20/h9-20,25-29H,5-8,22-24H2,1-4H3

Isomeri SMILES

CC(C1CCC(C(O1)OC2C(CC(C(C2O)OC3C(C(C(CO3)(C)O)NC)O)N)N)N)NC

CAS alternativo

1403-66-3

Termini MeSH

G Myticin;G-Myticin;Garamycin;Gentacycol;Gentamicin;Gentamicin Sulfate;Gentamicin Sulfate (USP);Gentamicins;Gentamycin;Gentamycins;Gentavet;Genticin;GMyticin;Sulfate, Gentamicin

Reaxy-Rn

1357063

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1357063&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic oxygen compounds
    • Classe Organooxygen compounds
      • Subclass Carbohydrates and carbohydrate conjugates
        • Level5 Aminosaccharides
          • Level6 Aminoglycosides
            • Level7 Aminocyclitol glycosides

• Kingdom: Organic compounds
• Superclass: Organic oxygen compounds
• Classe: Organooxygen compounds
• Subclass: Carbohydrates and carbohydrate conjugates
• Intermediate Tree Nodes: Aminosaccharides - Aminoglycosides
• Direct Parent: Aminocyclitol glycosides
• Alternative Parents: 2-deoxystreptamine aminoglycosides O-glycosyl compounds Aminocyclitols and derivatives Cyclohexylamines Cyclohexanols Oxanes Monosaccharides Tertiary alcohols 1,2-aminoalcohols Oxacyclic compounds Dialkylamines Acetals Organopnictogen compounds Monoalkylamines Hydrocarbon derivatives
• Molecular Framework: Aliphatic heteromonocyclic compounds
• Substituents: Amino cyclitol glycoside - 2-deoxystreptamine aminoglycoside - Glycosyl compound - O-glycosyl compound - Aminocyclitol or derivatives - Cyclohexanol - Cyclohexylamine - Cyclitol or derivatives - Monosaccharide - Oxane - Tertiary alcohol - Cyclic alcohol - Secondary alcohol - 1,2-aminoalcohol - Secondary amine - Acetal - Organoheterocyclic compound - Secondary aliphatic amine - Oxacycle - Alcohol - Hydrocarbon derivative - Primary aliphatic amine - Organopnictogen compound - Organic nitrogen compound - Amine - Primary amine - Organonitrogen compound - Aliphatic heteromonocyclic compound
• Descrizione: This compound belongs to the class of organic compounds known as aminocyclitol glycosides. These are organic compounds containing an amicocyclitol moiety glycosidically linked to a carbohydrate moiety. There are two major classes of aminoglycosides containing a 2-streptamine core. They are called 4,5- and 4,6-disubstituted 2-deoxystreptamines.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Obiettivi associati (umani)

TRPA1 Tclin Transient receptor potential cation channel subfamily A member 1 (1 Activities)

Discover Target: TRPA1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TRPV5 Tchem Transient receptor potential cation channel subfamily V member 5 (0 Activities)

Discover Target: TRPV5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Meccanismi d'azione

Proprietà chimiche e fisiche

• Sensibilità: Moisture sensitive;Heat sensitive;Light sensitive
• Peso molecolare: 477.600 g/mol
• XLogP3: -4.100
• Hydrogen Bond Donor Count: 8
• Hydrogen Bond Acceptor Count: 12
• Rotatable Bond Count: 7
• Exact Mass: 477.316 Da
• Monoisotopic Mass: 477.316 Da
• Topological Polar Surface Area: 200.000 Ų
• Heavy Atom Count: 33
• Formal Charge: 0
• Complexity: 636.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 13
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1