GppNHp - ≥95% , CAS No.64564-03-0

CAS: 64564-03-0 Cat. No.: G276465 Formula: C₁₀H₁₃N₆O₁₃P₃ • 4Li Peso molecolare: 545.93 PubChem CID: 135889524

GRADE & PURITY ≥95%

Synonyms

DTXSID30657541 | Tetralithium 2-amino-9-[5-O-({[(phosphonatoamino)phosphinato]oxy}phosphinato)pentofuranosyl]-3,9-dihydro-6H-purin-6-one | 5'-Guanylylimidodiphosphate Tetralithium Salt | Tetralithium;[[5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2

Storage

Store at -20°C,Desiccated

Shipped In

Ice chest + Ice pads

Panoramica

Guanylyl imidodiphosphate lithium (Gpp (NH) p lithium) is a non-hydrolyzable GTP analog. Guanylyl imidodiphosphate lithium increases adenylate cyclase activity. Guanylyl imidodiphosphate lithium binds to and irreversibly activates G proteins.

Specifications

Sinonimi

DTXSID30657541 | Tetralithium 2-amino-9-[5-O-({[(phosphonatoamino)phosphinato]oxy}phosphinato)pentofuranosyl]-3,9-dihydro-6H-purin-6-one | 5'-Guanylylimidodiphosphate Tetralithium Salt | Tetralithium;[[5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2

Specifiche e purezza

≥95%

Meccanismi biochimici e fisiologici

Non-hydrolyzable GTP analog. Has an amine group in place of an oxygen atom. Potent adenylate cyclase stimulator. Binds tightly to G-protein in the presence of Mg 2+ . Forms stable Ras complexes.

Condizioni di conservazione di stoccaggio

Store at -20°C,Desiccated

Spedito in

Ice chest + Ice pads

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Tipo di azione

ACTIVATOR

Nota

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Purezza

≥95%

Nomi e identificatori

• Pubchem Sid: 504773451
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504773451
• Sorrisi canonici: [Li+].[Li+].[Li+].[Li+].C1=NC2=C(N1C3C(C(C(O3)COP(=O)([O-])OP(=O)(NP(=O)([O-])[O-])[O-])O)O)N=C(NC2=O)N
• IUPAC Name: tetralithium;[[5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl]oxy-(phosphonatoamino)phosphinate
• InChIKey: NUKFMILQQVRELO-UHFFFAOYSA-J
• INCHI: 1S/C10H17N6O13P3.4Li/c11-10-13-7-4(8(19)14-10)12-2-16(7)9-6(18)5(17)3(28-9)1-27-32(25,26)29-31(23,24)15-30(20,21)22;;;;/h2-3,5-6,9,17-18H,1H2,(H,25,26)(H3,11,13,14,19)(H4,15,20,21,22,23,24);;;;/q;4*+1/p-4
• Isomeri SMILES: [Li+].[Li+].[Li+].[Li+].C1=NC2=C(N1C3C(C(C(O3)COP(=O)([O-])OP(=O)(NP(=O)([O-])[O-])[O-])O)O)N=C(NC2=O)N
• PubChem CID: 135889524
• Peso molecolare: 545.93

Proprietà chimiche e fisiche

• Solubilità: Soluble in water to 75 mM

Riferimenti

1. Liu Chuqi, Liu Dexiang, Zheng Xiang, Guan Jiali, Zhou Xinyan, Zhang Haikun, Wang Shen, Li Qiubai, Lu Gan, He Jun, Ma Cong.  (2025)  Munc13-4 mediates tumor immune evasion by regulating the sorting and secretion of PD-L1 via exosomes.  Nature Communications,  16  (1): (1-24).  [PMID:41083534] [10.1038/s41467-025-64149-9]

Domande frequenti

What is the purity of this product?

This product is supplied at ≥95% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C, desiccated. Keep the container tightly closed with desiccant — the material is moisture-sensitive.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 64564-03-0, the molecular formula is C10H13N6O13P3 ? 4Li, and the molecular weight is 545.93 g/mol. InChIKey NUKFMILQQVRELO-UHFFFAOYSA-J.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.