GSK2643943A - ≥98% , CAS No.2449301-27-1

CAS: 2449301-27-1 Cat. No.: G413665 Formula: C₁₇H₁₂FN₃ Peso molecolare: 277.3

GRADE & PURITY ≥98%

Synonyms

1H-​Indole-​3-​carbonitrile,2-​amino-​6-​[2-​(3-​fluorophenyl)​ethenyl]​-

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Panoramica

Information

GSK2643943A is an inhibitor ofdeubiquitylating enzyme (DUB)with IC50 of 160 nM forUSP20/Ub-Rho.

Targets

USP20/Ub-Rho (Cell-free assay) 160 nM

Specifications

Sinonimi

1H-​Indole-​3-​carbonitrile,2-​amino-​6-​[2-​(3-​fluorophenyl)​ethenyl]​-

Specifiche e purezza

≥98%

Meccanismi biochimici e fisiologici

GSK2643943A is an inhibitor of deubiquitylating enzyme (DUB) with IC50 of 160 nM for USP20/Ub-Rho.

Condizioni di conservazione di stoccaggio

Store at -20°C

Spedito in

Ice chest + Ice pads

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Tipo di azione

INHIBITOR

Purezza

≥98%

Proprietà del prodotto

• ALogP: 3.571
• Conteggio HBD: 2
• Legame rotabile: 2

Nomi e identificatori

• Pubchem Sid: 504773490
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504773490
• Sorrisi canonici: C1=CC(=CC(=C1)F)C=CC2=CC3=C(C=C2)C(=C(N3)N)C#N
• IUPAC Name: 2-amino-6-[(E)-2-(3-fluorophenyl)ethenyl]-1H-indole-3-carbonitrile
• InChIKey: CGXBPMZRTMXEIA-SNAWJCMRSA-N
• INCHI: 1S/C17H12FN3/c18-13-3-1-2-11(8-13)4-5-12-6-7-14-15(10-19)17(20)21-16(14)9-12/h1-9,21H,20H2/b5-4+
• Peso molecolare: 277.3
• Reaxy-Rn: 38910864
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=38910864&ln=

Proprietà chimiche e fisiche

• Solubilità: Solubility (25°C) In vitro DMSO: 55 mg/mL (198.34 mM); Ethanol: 8 mg/mL (28.84 mM); Water: Insoluble
• DMSO (mg/mL) Solubilità massima: 55
• DMSO (mM) Solubilità massima: 198.341146772449
• Acqua (mg/mL) Solubilità massima: ＜1
• Peso molecolare: 277.290 g/mol
• XLogP3: 4.300
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 277.102 Da
• Monoisotopic Mass: 277.102 Da
• Topological Polar Surface Area: 65.600 Ų
• Heavy Atom Count: 21
• Formal Charge: 0
• Complexity: 441.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 1
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 1
• Covalently-Bonded Unit Count: 1

Domande frequenti

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2449301-27-1, the molecular formula is C17H12FN3, and the molecular weight is 277.3 g/mol. InChIKey CGXBPMZRTMXEIA-SNAWJCMRSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.