≥99% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Argon charged,Desiccated,Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Hemokinin 1 (mouse) is a selective agonist of neurokinin-1 receptor , with K i of 0.175 nM and 560 nM for human NK1 receptor and human NK2 receptor, respectively.
In Vitro
Hemokinin 1 (mouse) (1 nM-3 μM) produces concentration-dependent contraction of RUB averaging 66±3% (n=6) of the maximal contraction produced by KCl (80 mM). Hemokinin 1 (mouse) (10 nM-10 μM) induces a quickly-developing contractile responses of GPI, as does the tachykinin NK3 receptor selective agonist senktide or neurokinin B (NKB). Hemokinin 1 (mouse) induces full agonist responses but with a 500 fold lower potency as compared to NKB. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Hemokinin 1 (mouse) (0.01-100 nmol/kg i.v., n=10) induces a dose-related hypotension that is maximal at the dose of 10 nmol/kg. For systolic blood pressure (SBP), the ED 50 value is 0.2 nmol/kg (0.1-0.4 nmol/kg) for Hemokinin 1 (mouse). For diastolic blood pressure (DBP), the ED 50 value is 0.1 nmol/kg (0.07-0.2 nmol/kg) for Hemokinin 1 (mouse). Hemokinin 1 (mouse) (0.1-100 nmol/kg, i.v.) induces a dose-related salivary secretion in atropine-pretreated rats . MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Form:Solid
IC50& Target:Ki: 0.175 nM (Human NK1 receptor), 560 nM (Human NK2 receptor)
Comprehensive hazard, handling, storage, and regulatory compliance document.
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View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Organic Polymers |
| Classe | Polypeptides |
| Subclass | Not available |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Polypeptides |
| Alternative Parents | Peptides Tyrosine and derivatives Phenylalanine and derivatives Glutamine and derivatives Leucine and derivatives Methionine and derivatives N-acyl-alpha amino acids and derivatives Alpha amino acid amides Serine and derivatives Amphetamines and derivatives 1-hydroxy-2-unsubstituted benzenoids N-acyl amines Primary carboxylic acid amides Secondary carboxylic acid amides Secondary alcohols Guanidines Sulfenyl compounds Dialkylthioethers Carboximidamides Propargyl-type 1,3-dipolar organic compounds Organic oxides Monoalkylamines Hydrocarbon derivatives Carbonyl compounds Primary alcohols Organopnictogen compounds |
| Molecular Framework | Aromatic homomonocyclic compounds |
| Substituents | Polypeptide - Alpha peptide - Tyrosine or derivatives - Phenylalanine or derivatives - Glutamine or derivatives - Leucine or derivatives - Methionine or derivatives - N-acyl-alpha amino acid or derivatives - Alpha-amino acid amide - Serine or derivatives - N-substituted-alpha-amino acid - Alpha-amino acid or derivatives - Amphetamine or derivatives - 1-hydroxy-2-unsubstituted benzenoid - Phenol - Monocyclic benzene moiety - Fatty amide - N-acyl-amine - Fatty acyl - Benzenoid - Secondary carboxylic acid amide - Secondary alcohol - Primary carboxylic acid amide - Amino acid or derivatives - Carboxamide group - Guanidine - Thioether - Propargyl-type 1,3-dipolar organic compound - Organic 1,3-dipolar compound - Dialkylthioether - Sulfenyl compound - Carboximidamide - Carboxylic acid derivative - Primary amine - Primary aliphatic amine - Organic oxygen compound - Organic nitrogen compound - Hydrocarbon derivative - Organonitrogen compound - Carbonyl group - Alcohol - Organic oxide - Organooxygen compound - Organosulfur compound - Organopnictogen compound - Primary alcohol - Amine - Aromatic homomonocyclic compound |
| Descrizione | This compound belongs to the class of organic compounds known as polypeptides. These are peptides containing ten or more amino acid residues. |
| External Descriptors | Not available |
| Solubilità | DMSO : 100 mg/mL (70.74 mM; Need ultrasonic) |
|---|---|
| Peso molecolare | 1413.700 g/mol |
| XLogP3 | -5.900 |
| Hydrogen Bond Donor Count | 22 |
| Hydrogen Bond Acceptor Count | 20 |
| Rotatable Bond Count | 47 |
| Exact Mass | 1412.75 Da |
| Monoisotopic Mass | 1412.75 Da |
| Topological Polar Surface Area | 682.000 Ų |
| Heavy Atom Count | 99 |
| Formal Charge | 0 |
| Complexity | 2720.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 11 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
