JMV 2959 hydrochloride - ≥98% , CAS No.2448414-54-6

CAS: 2448414-54-6 Cat. No.: J650413 Formula: C₃₀H₃₃ClN₆O₂ Peso molecolare: 545.08

GRADE & PURITY ≥98%

Storage

Store at 2-8°C,Desiccated

Shipped In

Wet ice

Panoramica

JMV 2959 hydrochloride is a growth hormone secretagogue receptor type 1a ( GHS-R 1a ) antagonist with an IC 50 of 32±3 nM in LLC-PK 1 cells.

In Vitro

JMV 2959 is a growth hormone secretagogue receptor type 1a (GHS-R 1a ) antagonist with an IC 50 of 32 nM. JMV 2959 does not induce any intracellular calcium mobilization by itself. The dissociation constant of the receptor/JMV 2959 complex is determined by the Schild method. This experiment reveals a dissociation constant Kb of 19±6 nM. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Intraperitoneal (i.p.) administration of Ghrelin (0.033, 0.1, and 0.33 mg/kg) does not alter the acoustic startle responses (ASR) or prepulse inhibition (PPI) in rats. Conversely, i.p. injection of JMV 2959 (1, 3, and 6 mg/kg), dose dependently decrease the ASR and increase PPI. Pretreatment with JMV 2959 at a dose with no effect on ASR or PPI per se, completely blocks Phencyclidine (PCP)-induced (2 mg/kg) deficits in PPI while pretreatment with the highest dose of Ghrelin does not potentiate or alter PPI responses of a sub-threshold dose of PCP (0.75 mg/kg). MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal administration

Rats Two-hundred-gram male Sprague-Dawley rats are used in the study. The animals (n=15) are randomly assigned to an initial treatment dose or vehicle and subsequently receive all the different doses tested in a counter balanced design. Each test is separated by a 3- to 4-day-long washout period. The rats are given the i.p. injection of JMV 2959 (1, 3, and 6 mg/kg) (or vehicle) 17 min prior to being placed in the startle cages (i.e., 25 min prior to the first pulse) . aladdin has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:IC50: 32±3 nM (GHS-R 1a , in LLC-PK 1 cells)

Specifications

Specifiche e purezza

≥98%

Meccanismi biochimici e fisiologici

JMV 2959 hydrochloride is a growth hormone secretagogue receptor type 1a ( GHS-R 1a ) antagonist with an IC 50 of 32±3 nM in LLC-PK 1 cells.

Condizioni di conservazione di stoccaggio

Store at 2-8°C,Desiccated

Spedito in

Wet ice

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Tipo di azione

ANTAGONIST

Purezza

≥98%

Nomi e identificatori

Peso molecolare

545.08

Proprietà chimiche e fisiche

• Solubilità: DMSO : 250 mg/mL (458.65 mM; Need ultrasonic) H2O : 25 mg/mL (45.86 mM; Need ultrasonic)

Domande frequenti

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at 2–8 °C, desiccated. Keep the container tightly closed with desiccant — the material is moisture-sensitive.

How is this product shipped?

This product ships chilled on wet ice. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2448414-54-6, the molecular formula is C30H33ClN6O2, and the molecular weight is 545.08 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.