Levalbuterol tartrate - ≥99% , CAS No.661464-94-4

CAS: 661464-94-4 Cat. No.: L412848 Formula: C₃₀H₄₈N₂O₁₂ Peso molecolare: 628.71 Numero EC: 627-134-8

GRADE & PURITY ≥99%

Synonyms

(R)-4-(2-(tert-butylamino)-1-hydroxyethyl)-2-(hydroxymethyl)phenol (2R,3R)-2,3-dihydroxysuccinic acid | (R)-4-(2-(tert-Butylamino)-1-hydroxyethyl)-2-(hydroxy-methyl)phenol (2R,3R)-2,3-dihydroxysuccinate | (R)-4-(2-(tert-Butylamino)-1-hydroxyethyl)-2-(hydr

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Panoramica

Information

Levalbuterol tartrate Levalbuterol HCl is a relatively selective beta2-adrenergic receptor agonist used for the treatment of asthma.

In vivo

Racemic albuterol (7.5 mg, bid) results in a greater improvement in their forced expiratory volume in 1 second (FEV1) as well as in their asthma scores after 1 hour of continuous treatment compared to the Levalbuterol (3.75 mg, bid) administration in children with asthma. The greater improvement in asthma scores is maintained after the second hour of continuous therapy in the racemic albuterol group but not for forced expiratory volume in 1 second (FEV1) measurements. Levalbuterol (1.25 mg) requires significantly fewer median total nebulizations and scheduled nebulizations compared with those in the racemic albuterol (2.5 mg) group in patients with asthma or chronic obstructive pulmonary disease (COPD). Disease symptom assessment and subject general well-being score scores improves significantly from baseline in both levalbuterol (1.25 mg) and racemic albuterol (2.5 mg) treatment groups, and beta-mediated adverse effects mean scores are significantly greater with levalbuterol versus racemic albuterol.

Application:

Levosalbutamol tartrate(levalbuterol) is the R-enantiomer of the short-acting β2-adrenergic receptor agonist salbutamol.

Specifications

Sinonimi

(R)-4-(2-(tert-butylamino)-1-hydroxyethyl)-2-(hydroxymethyl)phenol (2R,3R)-2,3-dihydroxysuccinic acid | (R)-4-(2-(tert-Butylamino)-1-hydroxyethyl)-2-(hydroxy-methyl)phenol (2R,3R)-2,3-dihydroxysuccinate | (R)-4-(2-(tert-Butylamino)-1-hydroxyethyl)-2-(hydr

Specifiche e purezza

≥99%

Meccanismi biochimici e fisiologici

Levalbuterol HCl is a relatively selective beta2-adrenergic receptor agonist used for the treatment of asthma.

Condizioni di conservazione di stoccaggio

Store at -20°C

Spedito in

Ice chest + Ice pads

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Tipo di azione

AGONIST

Purezza

≥99%

Nomi e identificatori

Pubchem Sid

488201433

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/488201433

Sorrisi canonici

CC(C)(C)NCC(C1=CC(=C(C=C1)O)CO)O.C(C(C(=O)O)O)(C(=O)O)O

IUPAC Name

4-[(1R)-2-(tert-butylamino)-1-hydroxyethyl]-2-(hydroxymethyl)phenol;(2R,3R)-2,3-dihydroxybutanedioic acid

InChIKey

SQOXPNYIJRDVRE-RVHANOPWSA-N

INCHI

1S/C13H21NO3.C4H6O6/c1-13(2,3)14-7-12(17)9-4-5-11(16)10(6-9)8-15;5-1(3(7)8)2(6)4(9)10/h4-6,12,14-17H,7-8H2,1-3H3;1-2,5-6H,(H,7,8)(H,9,10)/t12-;1-,2-/m01/s1

Isomeri SMILES

CC(C)(C)NC[C@@H](C1=CC(=C(C=C1)O)CO)O.[C@@H]([C@H](C(=O)O)O)(C(=O)O)O

Peso molecolare

628.71

Reaxy-Rn

33764176

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=33764176&ln=

Proprietà chimiche e fisiche

• Solubilità: Solubility (25°C) In vitro DMSO: 100 mg/mL (159.05 mM); Water: 100 mg/mL (159.05 mM); Ethanol: Insoluble