PCSK9

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  1. Anacetrapib, Cholesteryl ester transfer protein inhibitor
    CAS: 875446-37-0 Numero EC: 810-468-5 Formula: C30H25F10NO3 Peso molecolare: 637.51
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● In magazzino — Magazzino negli USA, spedizione nell'EU* Oggetto #: A127068
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    (4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-[[2-(4-fluoro-2-methoxy-5-propan-2-ylphenyl)-5-(trifluoromethyl)phenyl]methyl]-4-methyl-1,3-oxazolidin-2-show more
    SMILES
    CC1C(OC(=O)N1CC2=C(C=CC(=C2)C(F)(F)F)C3=CC(=C(C=C3OC)F)C(C)C)C4=CC(=CC(=C4)C(F)(F)F)C(F)(F)F
    InChIKey
    MZZLGJHLQGUVPN-HAWMADMCSA-N
    InChI
    1S/C30H25F10NO3/c1-14(2)22-11-23(25(43-4)12-24(22)31)21-6-5-18(28(32,33)34)9-17(21)13-41-15(3)26(44-27(41)42)16-7-19(29(35,36)37)10-20(8-16)30(38,39)4show more
    Sinonimi
    Anacetrapib - MK-0859 | s2748 | KBio3_001100 | MLS006010190 | A24886 | BDBM50348228 | STL554443 | Anacetrapib (JAN/US...
  2. Pep 2-8
    CAS: 1541011-97-5 PubChem CID: 124221781 Formula: C83H110N16O24 Peso molecolare: 1715.88
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥95%
    ● In magazzino — Magazzino negli USA, spedizione nell'EU* Oggetto #: P286980
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    Nome IUPAC
    (4S)-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-acetamido-3-hydroxybutanoyl]amino]-3-methylbutanoyl]amino]-3-phenylpropanoshow more
    SMILES
    CC(C)CC(C(=O)NC(CC(=O)O)C(=O)NC(CC1=CNC2=CC=CC=C21)C(=O)NC(C(C)C)C(=O)N)NC(=O)C(CC3=CC=C(C=C3)O)NC(=O)C(CCC(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C(CC4=CNC5=CC=show more
    InChIKey
    ORPZALWAWWEEDP-NXXUBLNKSA-N
    InChI
    1S/C83H110N16O24/c1-40(2)31-57(74(114)94-62(36-66(109)110)77(117)92-61(79(119)97-67(41(3)4)71(84)111)35-49-38-86-54-22-16-14-20-52(49)54)90-75(115)58(show more
  3. 2-Hydroxy-5-methoxy-3-undecyl-[1,4]benzoquinone
    CAS: 56005-10-8 Formula: C18H28O4 Peso molecolare: 308.418
    ◐ .Su ordinazione · 8–12 settimane Oggetto #: H391098
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    2-hydroxy-5-methoxy-3-undecylcyclohexa-2,5-diene-1,4-dione
    SMILES
    CCCCCCCCCCCC1=C(C(=O)C=C(C1=O)OC)O
    InChIKey
    KHBJLRRAMCJZLZ-UHFFFAOYSA-N
    InChI
    1S/C18H28O4/c1-3-4-5-6-7-8-9-10-11-12-14-17(20)15(19)13-16(22-2)18(14)21/h13,20H,3-12H2,1-2H3
    Sinonimi
    HY-W510159 | 4H3R9623BA | 2,5-Cyclohexadiene-1,4-dione, 2-hydroxy-5-methoxy-3-undecyl- | 2-hydroxy-5-methoxy-3-undecy...
  4. Alirocumab (anti-PCSK9)
    CAS: 1245916-14-6
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥95% 75mg/ml in buffer
    ● In magazzino — Magazzino negli USA, spedizione nell'EU* Oggetto #: A302291
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    Associated targets
    PCSK9
    Specie reattive
    Umano
    Isotipo
    Human IgG1
    Specie ospite
    Umano
    Coniugazione
    Unconjugated
    SMILES
    C(C(COP(=O)(O)O)O)O.[Na].[Na]
    InChIKey
    CATWCRUATKKAAQ-UHFFFAOYSA-N
    InChI
    1S/C3H9O6P.2Na/c4-1-3(5)2-9-10(6,7)8;;/h3-5H,1-2H2,(H2,6,7,8);;
    Sinonimi
    BCP25199 | CID 88214187 | 1245916-14-6 | B0084-007210 | SCHEMBL7870957 | BA165582
  5. PF-06446846
    CAS: 1632250-49-7 PubChem CID: 86271238 Formula: C22H20ClN7O Peso molecolare: 433.89
    ◐ .Su ordinazione · 8–12 settimane Oggetto #: P412585
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    N-(3-chloropyridin-2-yl)-N-[(3R)-piperidin-3-yl]-4-(triazolo[4,5-b]pyridin-3-yl)benzamide
    SMILES
    C1CC(CNC1)N(C2=C(C=CC=N2)Cl)C(=O)C3=CC=C(C=C3)N4C5=C(C=CC=N5)N=N4
    InChIKey
    FDTXHWQFIXYHCL-QGZVFWFLSA-N
    InChI
    1S/C22H20ClN7O/c23-18-5-2-12-25-20(18)29(17-4-1-11-24-14-17)22(31)15-7-9-16(10-8-15)30-21-19(27-28-30)6-3-13-26-21/h2-3,5-10,12-13,17,24H,1,4,11,14H2/show more
    Sinonimi
    N-(3-Chloropyridin-2-yl)-N-((3R)-piperidin-3-yl)-4-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)benzamide
  6. R-IMPP
    CAS: 2133832-83-2 PubChem CID: 122198706 Formula: C24H27N3O2 Peso molecolare: 389.49
    10mM in DMSO
    ● In magazzino — Magazzino negli USA, spedizione nell'EU* Oggetto #: R422578
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    N-isoquinolin-1-yl-3-(4-methoxyphenyl)-N-[(3R)-piperidin-3-yl]propanamide
    SMILES
    COC1=CC=C(C=C1)CCC(=O)N(C2CCCNC2)C3=NC=CC4=CC=CC=C43
    InChIKey
    OKTGXQMSOIQCTJ-HXUWFJFHSA-N
    InChI
    1S/C24H27N3O2/c1-29-21-11-8-18(9-12-21)10-13-23(28)27(20-6-4-15-25-17-20)24-22-7-3-2-5-19(22)14-16-26-24/h2-3,5,7-9,11-12,14,16,20,25H,4,6,10,13,15,17show more
    Sinonimi
    (R)-N-(isoquinolin-1-yl)-3-(4-methoxyphenyl)-N-(piperidin-3-yl)propanamide | PF-00932239
  7. R-IMPP
    CAS: 2133832-83-2 PubChem CID: 122198706 Formula: C24H27N3O2 Peso molecolare: 389.49
    ● In magazzino — Magazzino negli USA, spedizione nell'EU* Oggetto #: R414007
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    Nome IUPAC
    N-isoquinolin-1-yl-3-(4-methoxyphenyl)-N-[(3R)-piperidin-3-yl]propanamide
    SMILES
    COC1=CC=C(C=C1)CCC(=O)N(C2CCCNC2)C3=NC=CC4=CC=CC=C43
    InChIKey
    OKTGXQMSOIQCTJ-HXUWFJFHSA-N
    InChI
    1S/C24H27N3O2/c1-29-21-11-8-18(9-12-21)10-13-23(28)27(20-6-4-15-25-17-20)24-22-7-3-2-5-19(22)14-16-26-24/h2-3,5,7-9,11-12,14,16,20,25H,4,6,10,13,15,17show more
    Sinonimi
    (R)-N-(isoquinolin-1-yl)-3-(4-methoxyphenyl)-N-(piperidin-3-yl)propanamide | PF-00932239
  8. SBC-110736
    CAS: 1629166-02-4 PubChem CID: 78425817 Formula: C26H27N3O2 Peso molecolare: 413.51
    10mM in DMSO
    ● In magazzino — Magazzino negli USA, spedizione nell'EU* Oggetto #: S421998
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    N-[4-[4-(4-methylphenyl)-2-phenylpiperazine-1-carbonyl]phenyl]acetamide
    SMILES
    CC1=CC=C(C=C1)N2CCN(C(C2)C3=CC=CC=C3)C(=O)C4=CC=C(C=C4)NC(=O)C
    InChIKey
    PILMFSWQYWYOJC-UHFFFAOYSA-N
    InChI
    1S/C26H27N3O2/c1-19-8-14-24(15-9-19)28-16-17-29(25(18-28)21-6-4-3-5-7-21)26(31)22-10-12-23(13-11-22)27-20(2)30/h3-15,25H,16-18H2,1-2H3,(H,27,30)
    Sinonimi
    N-[4-(2-Phenyl-4-p-tolyl-piperazine-1-carbonyl)-phenyl]-acetamide
  9. SBC-110736
    CAS: 1629166-02-4 PubChem CID: 78425817 Formula: C26H27N3O2 Peso molecolare: 413.51
    ● In magazzino — Magazzino negli USA, spedizione nell'EU* Oggetto #: S412188
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    Nome IUPAC
    N-[4-[4-(4-methylphenyl)-2-phenylpiperazine-1-carbonyl]phenyl]acetamide
    SMILES
    CC1=CC=C(C=C1)N2CCN(C(C2)C3=CC=CC=C3)C(=O)C4=CC=C(C=C4)NC(=O)C
    InChIKey
    PILMFSWQYWYOJC-UHFFFAOYSA-N
    InChI
    1S/C26H27N3O2/c1-19-8-14-24(15-9-19)28-16-17-29(25(18-28)21-6-4-3-5-7-21)26(31)22-10-12-23(13-11-22)27-20(2)30/h3-15,25H,16-18H2,1-2H3,(H,27,30)
    Sinonimi
    N-[4-(2-Phenyl-4-p-tolyl-piperazine-1-carbonyl)-phenyl]-acetamide
  10. SBC-115076
    CAS: 489415-96-5 Numero EC: 134-737-5 PubChem CID: 5734410 Formula: C31H33N3O5 Peso molecolare: 527.61
    10mM in DMSO
    ● In magazzino — Magazzino negli USA, spedizione nell'EU* Oggetto #: S424240
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    Nome IUPAC
    (4E)-4-[hydroxy-(3-methyl-4-phenylmethoxyphenyl)methylidene]-1-(3-morpholin-4-ylpropyl)-5-pyridin-4-ylpyrrolidine-2,3-dione
    SMILES
    CC1=C(C=CC(=C1)C(=C2C(N(C(=O)C2=O)CCCN3CCOCC3)C4=CC=NC=C4)O)OCC5=CC=CC=C5
    InChIKey
    VVYIXKBHQQSREP-ORIPQNMZSA-N
    InChI
    1S/C31H33N3O5/c1-22-20-25(8-9-26(22)39-21-23-6-3-2-4-7-23)29(35)27-28(24-10-12-32-13-11-24)34(31(37)30(27)36)15-5-14-33-16-18-38-19-17-33/h2-4,6-13,20show more
    Sinonimi
    4-(4-(benzyloxy)-3-methylbenzoyl)-3-hydroxy-1-(3-morpholinopropyl)-5-(pyridin-4-yl)-1H-pyrrol-2(5H)-one
  11. SBC-115076
    CAS: 489415-96-5 PubChem CID: 5734410 Formula: C31H33N3O5 Peso molecolare: 527.61
    ● In magazzino — Magazzino negli USA, spedizione nell'EU* Oggetto #: S413896
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    Nome IUPAC
    (4E)-4-[hydroxy-(3-methyl-4-phenylmethoxyphenyl)methylidene]-1-(3-morpholin-4-ylpropyl)-5-pyridin-4-ylpyrrolidine-2,3-dione
    SMILES
    CC1=C(C=CC(=C1)C(=C2C(N(C(=O)C2=O)CCCN3CCOCC3)C4=CC=NC=C4)O)OCC5=CC=CC=C5
    InChIKey
    VVYIXKBHQQSREP-ORIPQNMZSA-N
    InChI
    1S/C31H33N3O5/c1-22-20-25(8-9-26(22)39-21-23-6-3-2-4-7-23)29(35)27-28(24-10-12-32-13-11-24)34(31(37)30(27)36)15-5-14-33-16-18-38-19-17-33/h2-4,6-13,20show more
    Sinonimi
    4-(4-(benzyloxy)-3-methylbenzoyl)-3-hydroxy-1-(3-morpholinopropyl)-5-(pyridin-4-yl)-1H-pyrrol-2(5H)-one
  12. Alirocumab (anti-PCSK9), Antibody of proprotein convertase subtilisin/kexin type 9
    CAS: 1245916-14-6
    Liquido Animal Free ? Animal-free — produced without animal-derived components to reduce contamination risk. Use in biomanufacturing and culture avoiding animal-origin material. Carrier Free ? Carrier-free — supplied without added carrier protein/stabilizer. Use when carriers (e.g. BSA) would interfere with conjugation or sensitive assays. Recombinant ? Recombinant — produced via recombinant expression for defined sequence and consistency. Use for reproducible, animal-free proteins of known origin. Validated ? Validated grade — performance confirmed in defined applications before release. Use when you want documented assurance the reagent works as stated. ExactAb™ ? ExactAb™ — Aladdin's antibody line emphasizing precision and validated quality. Use for reliable, specificity-validated antibody applications. Low Endotoxin ? Low-endotoxin grade — endotoxin reduced to low controlled levels. Use in sensitive biological work where high endotoxin would interfere. Azide Free ? Azide-free — without sodium azide preservative. Use in conjugations, cell work, or assays where azide is toxic or inhibitory. ≥95%(SDS-PAGE&SEC-HPLC) See COA
    ● In magazzino — Magazzino negli USA, spedizione nell'EU* Oggetto #: Ab169266
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    Associated targets
    PCSK9
    Short Overview
    Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
    Specie reattive
    Cynomolgus monkey, Mouse, Umano
    Isotipo
    Human IgG1
    Specie ospite
    Umano
    Coniugazione
    Unconjugated
    SMILES
    C(C(COP(=O)(O)O)O)O.[Na].[Na]
    InChIKey
    CATWCRUATKKAAQ-UHFFFAOYSA-N
    InChI
    1S/C3H9O6P.2Na/c4-1-3(5)2-9-10(6,7)8;;/h3-5H,1-2H2,(H2,6,7,8);;
    Sinonimi
    Recombinant Alirocumab Antibody | REGN 727 | SAR 236553 | Alirocumab (anti-PCSK9) | Anti-PCSK9 Reference Antibody (al...
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Domande frequenti

How is the PCSK9 listing put together?
It draws on reported PCSK9 annotations within Metabolic Enzyme/Protease and lists each compound with its structure, identifiers, and the activity published for it. Always check the underlying assay before comparing potency values across entries.
How do I choose a PCSK9 modulator for my assay?
Start from the assay format and readout — biochemical, cell-based, or in vivo — then compare the PCSK9 entries on potency, selectivity over related family members, and solubility in your vehicle. Where several chemotypes are available, a reference compound plus a structurally unrelated backup is the usual way to control for off-target effects.
Which specifications matter most for PCSK9 compounds?
Purity and identity confirmation come first, then solubility in DMSO or your chosen vehicle, recommended storage temperature, and stability in solution. For PCSK9 work in particular, freshly prepared stocks avoid most of the reproducibility problems seen with stored plates. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.
What if the PCSK9 compound I need is not listed?
Search by CAS number or SMILES first, since analogs of PCSK9 compounds are often catalogued under a related target. Custom synthesis and bulk enquiries go to [email protected]. We supply verified businesses, research institutions, universities, and government agencies.

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