Losartan - Moligand™, 10mM in DMSO , Antagonist of AT 1 receptor, CAS No.114798-26-4, Antagonist of AT 1 receptor

CAS: 114798-26-4 Cat. No.: L420721 Formula: C₂₂H₂₃ClN₆O Peso molecolare: 422.92 Numero EC: 601-329-8

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

losartan|114798-26-4|DUP 89|allisartan|Angizaar|Losartic|Hyzaar|Cozaar|Lozap|LOSARTAN POTASSIUM|CHEBI:6541|DUP-89|DTXSID7023227|UNII-JMS50MPO89|JMS50MPO89|Losartan (INN)|NSC-758699|HGP1405|HGP-1405|DuP-753|(2-butyl-4-chloro-1-{[2'-(1H-tetrazol-5-yl)biphen

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Panoramica

Losartan is a potent, non-peptide antagonist of angiotensin II receptor, type 1 (AT1). This receptor initiates a signal cascade that causes vasoconstriction. Antagonism of this receptor in turn causes vasodilation by blocking the signal from angiotensin II.

Specifications

Sinonimi

losartan | 114798-26-4 | DUP 89 | allisartan | Angizaar | Losartic | Hyzaar | Cozaar | Lozap | LOSARTAN POTASSIUM | CHEBI:6541 | DUP-89 | DTXSID7023227 | UNII-JMS50MPO89 | JMS50MPO89 | Losartan (INN) | NSC-758699 | HGP1405 | HGP-1405 | DuP-753 | (2-butyl-4-chloro-1-{[2'-(1H-tetrazol-5-yl)biphen

Specifiche e purezza

Moligand™, 10mM in DMSO

Meccanismi biochimici e fisiologici

Losartan is an orally available, potent, and selective competitive angiotensin II receptor type 1 (AT1) antagonist. Losartan is used for treatment of hypertension.

Condizioni di conservazione di stoccaggio

Store at -80°C

Spedito in

Dry ice packs + Cold packs

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Grado

Moligand™

Tipo di azione

ANTAGONIST

Meccanismo d'azione

Antagonist of AT 1 receptor

Nomi e identificatori

• Pubchem Sid: 528772930
• Sorrisi canonici: CCCCC1=NC(=C(N1CC2=CC=C(C=C2)C3=CC=CC=C3C4=NNN=N4)CO)Cl
• IUPAC Name: [2-butyl-5-chloro-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol
• InChIKey: PSIFNNKUMBGKDQ-UHFFFAOYSA-N
• INCHI: 1S/C22H23ClN6O/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22/h4-7,9-12,30H,2-3,8,13-14H2,1H3,(H,25,26,27,28)
• Isomeri SMILES: CCCCC1=NC(=C(N1CC2=CC=C(C=C2)C3=CC=CC=C3C4=NNN=N4)CO)Cl
• CAS alternativo: 114798-26-4,124750-99-8 (mono-potassium salt)
• Numero NSC: 758699
• Termini MeSH: 2-Butyl-4-chloro-1-((2'-(1H-etrazol-5-yl) (1,1'-biphenyl)-4-yl)methyl)-1H-imidazole-5-methanol;Cozaar;DuP 753;DuP-753;DuP753;Losartan;Losartan Monopotassium Salt;Losartan Potassium;MK 954;MK-954;MK954;Monopotassium Salt, Losartan;Potassium, Losartan;Salt,
• Peso molecolare: 422.92
• Reaxy-Rn: 4828951
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=4828951&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Classe Benzene and substituted derivatives
      • Subclass Biphenyls and derivatives

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Classe: Benzene and substituted derivatives
• Subclass: Biphenyls and derivatives
• Intermediate Tree Nodes: Not available
• Direct Parent: Biphenyls and derivatives
• Alternative Parents: Phenyltetrazoles and derivatives 1,2,4,5-tetrasubstituted imidazoles N-substituted imidazoles Aryl chlorides Heteroaromatic compounds Azacyclic compounds Primary alcohols Organopnictogen compounds Organonitrogen compounds Organochlorides Hydrocarbon derivatives Aromatic alcohols
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Biphenyl - Phenyltetrazole - 1,2,4,5-tetrasubstituted imidazole - Aryl chloride - Aryl halide - N-substituted imidazole - Azole - Heteroaromatic compound - Imidazole - Tetrazole - Azacycle - Organoheterocyclic compound - Organonitrogen compound - Organochloride - Organohalogen compound - Aromatic alcohol - Alcohol - Organic nitrogen compound - Hydrocarbon derivative - Organopnictogen compound - Organic oxygen compound - Organooxygen compound - Primary alcohol - Aromatic heteromonocyclic compound
• Descrizione: This compound belongs to the class of organic compounds known as biphenyls and derivatives. These are organic compounds containing to benzene rings linked together by a C-C bond.
• External Descriptors: imidazoles - biphenylyltetrazole

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Obiettivi associati (umani)

SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (0 Activities)

Discover Target: SLCO1B1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (0 Activities)

Discover Target: SLCO1B3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ACE Tclin Angiotensin-converting enzyme (0 Activities)

Discover Target: ACE

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AGTR1 Tclin Type-1 angiotensin II receptor (0 Activities)

Discover Target: AGTR1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AGTR2 Tchem Type-2 angiotensin II receptor (0 Activities)

Discover Target: AGTR2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Proprietà chimiche e fisiche

• Punto di fusione (°C): 183.5-184.5° C
• Peso molecolare: 422.900 g/mol
• XLogP3: 4.300
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 8
• Exact Mass: 422.162 Da
• Monoisotopic Mass: 422.162 Da
• Topological Polar Surface Area: 92.500 Ų
• Heavy Atom Count: 30
• Formal Charge: 0
• Complexity: 520.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Riferimenti

1. Qinglin Wang, Hao Yuan, Xinyue Pan, Yiling Yang, Xiaosong Ma, Yahui Guo.  (2023)  Synthesis of silver nanoclusters using a double-stranded DNA template and its application for captopril detection.  JOURNAL OF FOOD COMPOSITION AND ANALYSIS,      [PMID:] [10.1016/j.jfca.2023.105825]

2. Xinyang Li, Yang Luo, Zhengjie Huang, Yi Wang, Jian Wu, Shaobing Zhou.  (2023)  Multifunctional Liposomes Remodeling Tumor Immune Microenvironment for Tumor Chemoimmunotherapy.  Small Methods,  7  (5): (2201327).  [PMID:37075716] [10.1002/smtd.202201327]

3. Yihui Huang, Jingwen Li, Yan Wang, Danyang Chen, Jianglong Huang, Wubin Dai, Pan Peng, Liang Guo, Yifeng Lei.  (2022)  Intradermal delivery of an angiotensin II receptor blocker using a personalized microneedle patch for treatment of hypertrophic scars.  Biomaterials Science,  11  (2): (583-595).  [PMID:36475528] [10.1039/D2BM01631A]

4. Liqian Chen, Xinghong Zhou, Yijian Deng, Ying Yang, Xiaohu Chen, Qinghong Chen, Yanyan Liu, Xiuqiong Fu, Hiu Yee Kwan, Yanting You, Wen Jin, Xiaoshan Zhao.  (2022)  Zhenwu decoction ameliorates cardiac hypertrophy through activating sGC (soluble guanylate cyclase) - cGMP (cyclic guanosine monophosphate) - PKG (protein kinase G) pathway.  JOURNAL OF ETHNOPHARMACOLOGY,      [PMID:36099983] [10.1016/j.jep.2022.115705]

5. Sun Zhiping, He Lingli, Yang Qingqing, Zhang Haizhi, Xu Weiren, Qin Xinguang, Liu Gang, Hu Zhongze, Zhang Luyong, Liu Changxiao.  (2022)  Study on the Effect of Three CYP2C9 Variants on Drug–Drug Interaction Related to Six Drugs In Vitro by LC–MS/MS Method.  CHROMATOGRAPHIA,  85  (3): (221-231).  [PMID:] [10.1007/s10337-021-04126-8]

6. Yuanyuan Chai, Yunxia Xu, Ziyin Xia, Xin Huang, Luyong Zhang, Zhenzhou Jiang.  (2021)  Study on the effects of Zhuanggu Guanjie Pill, a modern Chinese medicine formula, on the activities and mRNA expression of seven CYP isozymes in rats.  JOURNAL OF ETHNOPHARMACOLOGY,      [PMID:34390794] [10.1016/j.jep.2021.114521]

7. Zhuoqing Cheng, Honghong Zhan, Han Yuan, Nan Wang, Yi Lan, Weijian Qu, Xiaozhong Lan, Zhihua Liao, Guowei Wang, Min Chen.  (2025)  Boeravinone C ameliorates lipid accumulation and inflammation in diabetic kidney disease by activating PPARα signaling.  JOURNAL OF ETHNOPHARMACOLOGY,      [PMID:39880066] [10.1016/j.jep.2025.119398]

8. Yanan Guo, Shuang Cao, Bin Geng, Juanjuan Ma, Bo Yao.  (2024)  Determination of sacubitril and seven sartan drugs in serum samples by online solid phase extraction-liquid chromatography-tandem mass spectrometry.  JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,      [PMID:39603194] [10.1016/j.jpba.2024.116580]

9. Haoyang Zou, Shuang Liao, Ruiqi Lu, Yong Pang, Junfeng Li, Jie Zhang.  (2025)  Geniposide regulates glucocorticoid receptor signaling to prevent lipid metabolism disorder in high-fat diet-fed zebrafish.  Food Bioscience,      [PMID:] [10.1016/j.fbio.2025.106277]

10. Bing Li, Shuanglong Mou, Chenrui Zhang, Tingting Zhu, Xingwei Hu, Mengsha Li.  (2025)  Ginsenoside Rh2 Ameliorates Myocardial Infarction by Regulating Cardiomyocyte Pyroptosis Based on Network Pharmacology, Molecular Docking, and Experimental Verification.  AMERICAN JOURNAL OF CHINESE MEDICINE,  53  (02): (475-499).  [PMID:40099395] [10.1142/S0192415X25500181]

11. Irfan Ijaz, Aysha Bukhari, Ammara Nazir, Ezaz Gilani, Hina Zain, Attia Shaheen, Mohammed Rafi Shaik, Mujeeb Khan.  (2025)  Modification of bacterial cellulose by MoBTx MBene and 1,4-dithiothreitol for rapid and efficient adsorption of indomethacin and losartan potassium.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:39922337] [10.1016/j.ijbiomac.2025.140745]

12. Zetao Heng, Min Hong, Zhaocai Zhang, Ximing Ye, Jianan Zhou, Wentao Wu, Jiabing Rong, Yinchuan Xu.  (2025)  Loss of Hepatic Angiotensinogen Attenuates Diastolic Dysfunction in Heart Failure with Preserved Ejection Fraction.  Advanced Science,      [PMID:40888605] [10.1002/advs.202507554]

13. Yi Zhou, Min Zhong, Guoxin Xie, Meirong Yi, Xiaobing Li, Jianfeng Chen, Wenhu Xu.  (2025)  Performance comparison and mechanism analysis between new nontoxic Losartan and traditional corrosion inhibitor BTA in cobalt chemical mechanical polishing.  TRIBOLOGY INTERNATIONAL,      [PMID:] [10.1016/j.triboint.2025.111239]

14. Huimin Xie, Lin Ma, Xiaoli He, Songsong Zhao, Jin Wang, Ao Zhu, Changming Liu, Olga Piskareva, Chao Deng, Fenghua Meng, Mi Liu.  (2025)  Elevating MHC I expression on tumor cells by nanovesicles loading tyrosine kinase inhibitors can improve the efficacy of cancer vaccines.  Frontiers in Immunology,      [PMID:41019037] [10.3389/fimmu.2025.1653533]

15. Zhong Shao, Ke Li, Hao Guo, Yangyang Cheng, Shiyong Zhang.  (2025)  An oral H2S nanotherapeutics for hypertensive chronic kidney disease via synergistic antihypertensive and renoprotective activities.  JOURNAL OF CONTROLLED RELEASE,      [PMID:41260269] [10.1016/j.jconrel.2025.114419]

16. He Mingjie, Wen Jie, Zou Yan, Jiang Qiong, Zhong Aimin.  (2026)  Elevated homocysteine contributes to the progression of type 1 diabetic nephropathy: Evidence from Mendelian randomization and experimental validation.  MEDICINE,  105  (5): (e47341).  [PMID:41630263] [10.1097/MD.0000000000047341]