Methoxamine hydrochloride - 10mM in DMSO , Adrenergic receptor alpha-1 agonist, CAS No.61-16-5, Adrenergic receptor alpha-1 agonist

CAS: 61-16-5 Cat. No.: M425064 Formula: C₁₁H₁₇NO₃ · HCl Peso molecolare: 247.72 Numero EC: 200-499-7

GRADE & PURITY 10mM in DMSO

Synonyms

METHOXAMINE HYDROCHLORIDE|61-16-5|Methoxamine HCl|2-amino-1-(2,5-dimethoxyphenyl)propan-1-ol hydrochloride|METHOXAMINEHYDROCHLORIDE|Vasoxine hydrochloride|NSC-757102|MLS000069686|Methoxamini hydrochloridum|2-amino-1-(2,5-dimethoxyphenyl)propan-1-ol;hydroc

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Specifications

Sinonimi

METHOXAMINE HYDROCHLORIDE | 61-16-5 | Methoxamine HCl | 2-amino-1-(2,5-dimethoxyphenyl)propan-1-ol hydrochloride | METHOXAMINEHYDROCHLORIDE | Vasoxine hydrochloride | NSC-757102 | MLS000069686 | Methoxamini hydrochloridum | 2-amino-1-(2,5-dimethoxyphenyl)propan-1-ol;hydroc

Specifiche e purezza

10mM in DMSO

Condizioni di conservazione di stoccaggio

Store at -80°C

Spedito in

Dry ice packs + Cold packs

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Tipo di azione

AGONIST

Meccanismo d'azione

Adrenergic receptor alpha-1 agonist

Nomi e identificatori

• Pubchem Sid: 528773515
• Sorrisi canonici: CC(C(C1=C(C=CC(=C1)OC)OC)O)N.Cl
• IUPAC Name: 2-amino-1-(2,5-dimethoxyphenyl)propan-1-ol;hydrochloride
• InChIKey: YGRFXPCHZBRUKP-UHFFFAOYSA-N
• INCHI: 1S/C11H17NO3.ClH/c1-7(12)11(13)9-6-8(14-2)4-5-10(9)15-3;/h4-7,11,13H,12H2,1-3H3;1H
• Isomeri SMILES: CC(C(C1=C(C=CC(=C1)OC)OC)O)N.Cl
• CAS alternativo: 390-28-3
• Peso molecolare: 247.72
• Reaxy-Rn: 6318453
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=6318453&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Classe Benzene and substituted derivatives
      • Subclass Methoxybenzenes

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Classe: Benzene and substituted derivatives
• Subclass: Methoxybenzenes
• Intermediate Tree Nodes: Not available
• Direct Parent: Dimethoxybenzenes
• Alternative Parents: Phenylpropanes Phenoxy compounds Anisoles Aralkylamines Alkyl aryl ethers Secondary alcohols 1,2-aminoalcohols Organopnictogen compounds Monoalkylamines Hydrochlorides Hydrocarbon derivatives Aromatic alcohols
• Molecular Framework: Aromatic homomonocyclic compounds
• Substituents: P-dimethoxybenzene - Dimethoxybenzene - Phenylpropane - Phenoxy compound - Anisole - Phenol ether - Alkyl aryl ether - Aralkylamine - 1,2-aminoalcohol - Secondary alcohol - Ether - Primary amine - Hydrochloride - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Primary aliphatic amine - Organic nitrogen compound - Organopnictogen compound - Amine - Organic oxygen compound - Alcohol - Aromatic alcohol - Aromatic homomonocyclic compound
• Descrizione: This compound belongs to the class of organic compounds known as dimethoxybenzenes. These are organic aromatic compounds containing a monocyclic benzene moiety carrying exactly two methoxy groups.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Obiettivi associati (umani)

PTH1R Tclin Parathyroid hormone receptor (47172 Activities)

Discover Target: PTH1R

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TP53 Tchem Cellular tumor antigen p53 (48468 Activities)

Discover Target: TP53

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)

Discover Target: EHMT2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

BLM Tchem Bloom syndrome protein (4248 Activities)

Discover Target: BLM

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GMNN Tbio Geminin (128009 Activities)

Discover Target: GMNN

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PMP22 Tbio Peripheral myelin protein 22 (699 Activities)

Discover Target: PMP22

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 Activities)

Discover Target: SLCO1B1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CBX1 Tbio Chromobox protein homolog 1 (92434 Activities)

Discover Target: CBX1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 Activities)

Discover Target: SLCO1B3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MEN1 Tchem Menin/Histone-lysine N-methyltransferase MLL (48157 Activities)

Discover Target: MEN1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Obiettivi associati (non umani)

Mapk1 MAP kinase ERK2 (650 Activities)

Discover Target: Mapk1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Plasmodium falciparum (966862 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

NS1 Nonstructural protein 1 (33327 Activities)

Discover Target: NS1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Meccanismi d'azione

Proprietà chimiche e fisiche

• Punto di fusione (°C): 212 - 216 °C
• Peso molecolare: 247.720 g/mol
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 247.098 Da
• Monoisotopic Mass: 247.098 Da
• Topological Polar Surface Area: 64.700 Ų
• Heavy Atom Count: 16
• Formal Charge: 0
• Complexity: 189.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 2
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

XLogP3

Riferimenti

1. Jia Sun, Zuying Zhou, Yang Zhou, Ting Liu, Yueting Li, Zipeng Gong, Yang Jin, Lin Zheng, Yong Huang.  (2023)  Anti-Rheumatoid Arthritis Pharmacodynamic Substances Screening of Periploca forrestii Schltr.: Component Analyses In Vitro and In Vivo Combined with Multi-Technical Metabolomics.  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,  24  (18): (13695).  [PMID:37761998] [10.3390/ijms241813695]

2. Bo Ye, Jian Li, Lijun Xu, Hui Liu, Manjun Yang.  (2022)  Metabolomic Effects of the Dietary Inclusion of Hermetia illucens Larva Meal in Tilapia.  Metabolites,  12  (4): (286).  [PMID:35448473] [10.3390/metabo12040286]

3. Jin-Xiu Liang, Qun-Qun Zhang, Yan-Fei Huang, Han-Qing Pang, Xin-Guang Liu, Wen Gao, Ping Li, Hua Yang.  (2019)  Comprehensive chemical profiling of monascus-fermented rice product and screening of lipid-lowering compounds other than monacolins.  JOURNAL OF ETHNOPHARMACOLOGY,      [PMID:30991138] [10.1016/j.jep.2019.111879]

4. Songbo Cheng, Hang Hu, Defeng Xu.  (2025)  A facile and green synthetic process of pyriminobac-methyl.  JOURNAL OF THE CHINESE INSTITUTE OF ENGINEERS,      [PMID:] [10.1080/02533839.2025.2464570]

5. Yanfeng Li, Haozheng Li, Ge Zhang, Jiale Liu, Dawa Drolma, Bo Ye, Manjun Yang.  (2024)  Boosted Meat Flavor by the Metabolomic Effects of Nile Tilapia Dietary Inclusion of Zophobas atratus Larval Meal.  Frontiers in Bioscience-Landmark,  29  (11): (382).  [PMID:39614443] [10.31083/j.fbl2911382]