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MK-6884 - ≥99% , CAS No.2102194-04-5
Disponibile su ordine
GRADE & PURITY ≥99%
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
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Why this grade
≥99% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Storage & shipping
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Panoramica
MK-6884 is a M4 muscarinic receptor positive allosteric modulator (PAM) with a K i value of 0.19 nM. MK-6884 can be used for the research of the neurodegenerative diseases. MK-6884 can be conveniently radiolabeled with carbon-11 and as a positron emission tomography (PET) imaging agent
In Vitro
MK-6884 (compound 13; 0-22 µM) is a PAM of ACh function in a cell-based Ca 2+ mobilization assay, with an EC 50 of 27 nM. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
[ 11 C]MK-6884 (compound 13) shows non-displaceable binding potential (BP ND ) of 0.83 in rhesus monkeys . [ 11 C]MK-6884 (approximately 185 MBq, <2 μg; single intravenous) distributes on the known presence of M4 receptors in the rhesus monkeys brain . [ 11 C]MK-688 can penetrate the blood-brain barrier in monkeys . MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Form:Solid
IC50& Target:mAChR4
Specifications
Specifiche e purezza
≥99%
Meccanismi biochimici e fisiologici
MK-6884 is a M4 muscarinic receptor positive allosteric modulator (PAM) with a K i value of 0.19 nM. MK-6884 can be used for the research of the neurodegenerative diseases. MK-6884 can be conveniently radiolabeled with carbon-11 and as a positron emissio
Condizioni di conservazione di stoccaggio
Store at -20°C
Spedito in
Ice chest + Ice pads
Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.
Tipo di azione
MODULATOR
Purezza
≥99%
Nomi e identificatori
| Peso molecolare | 411.50 |
|---|
Documentazione
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →✅ Certificate of Analysis (COA)
Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →🔬 Specification Sheet
Full quality attributes and acceptance criteria for this grade.
View spec sheet →Advanced Data
Certificati (CoA, COO, BSE/TSE e tabella di analisi)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Proprietà chimiche e fisiche
| Solubilità | THF : 3.33 mg/mL (8.09 mM; Need ultrasonic) |
|---|
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