ExactAb™, Validated, Carrier Free, 1.0mg/mL Carrier Free,ExactAb™,Validated for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -20°C,Avoid repeated freezing and thawing Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Mouse anti Human Mre11 Antibody, Monoclonal antibody, could be used for ELISA, WB, Flow, IHC and so on.
Application:
WB: 1/500 - 1/2000. Predicted molecular weight: 80.6 kDa.
IHC: 1/200 - 1/1000
Flow: 1/200 - 1/400
ELISA: 1/10000
Protein Function
Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11A to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation.
This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms.
Post-translational
Phosphorylated upon DNA damage, probably by ATM or ATR.
Mre11 Mouse mAb (Ab115912) - Western Blot
All lanes: Mre11 Mouse mAb (Ab115912) at 1/1000 dilution
Samples: Lysates at 20 µg per lane
Secondary: Goat Anti-Mouse IgG H&L (HRP) (Ab138040) at 1/30000 dilution
Predicted band size: 80.6 kDa
Observed band size: 84.2 kDa
Mre11 Mouse mAb (Ab115912) - Flow Cytometry
Flow cytometric analysis of cell line labeling Mre11 with Mre11 Mouse mAb (Ab115912) (green) compared with a negative control (red).
Mre11 Mouse mAb (Ab115912) - Flow Cytometry
Flow cytometric analysis of K562 cell line labeling Mre11 with Mre11 Mouse mAb (Ab115912) (green) compared with a negative control (red).
Mre11 Mouse mAb (Ab115912) - IHC
Immunohistochemical analysis of paraffin-embedded human ovarian cancer tissues using Mre11 Mouse mAb (Ab115912) with DAB staining.
Mre11 Mouse mAb (Ab115912) - IHC
Immunohistochemical analysis of paraffin-embedded human rectal cancer tissues using Mre11 Mouse mAb (Ab115912) with DAB staining.
Mre11 Mouse mAb (Ab115912) - IHC
Immunohistochemical analysis of paraffin-embedded Mouse testis tissues using Mre11 Mouse mAb (Ab115912) with DAB staining.
Mre11 Mouse mAb (Ab115912) - IHC
Immunohistochemical analysis of paraffin-embedded Rat testis tissues using Mre11 Mouse mAb (Ab115912) with DAB staining.
Mre11 Mouse mAb (Ab115912) - IHC
Immunohistochemical analysis of paraffin-embedded Rabbit testis tissues using Mre11 Mouse mAb (Ab115912) with DAB staining.
1/200-1/400
1/10000
1/200-1/1000
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View spec sheet →| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Data | Oggetto |
|---|---|---|---|
 ZJ23F0800754 | Certificate of Analysis | May 19, 2026 | Ab115912 |
| ZJ23F0800755 | Certificate of Analysis | May 19, 2026 | Ab115912 |
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