Nigakinone - Moligand™,≥98% , CAS No.18110-86-6

CAS: 18110-86-6 Cat. No.: N647372 Formula: C₁₅H₁₀N₂O₃ Peso molecolare: 266.25 PubChem CID: 5320161

QUALITÀ & PUREZZA Moligand™, ≥98%

Synonyms

PGFKZUOYIFDMQJ-UHFFFAOYSA-N | 6H-Indolo(3,2,1-de)(1,5)naphthyridin-6-one, 5-hydroxy-4-methoxy- | HMS2269C08 | MLS000574953 | J7E73434D2 | 6H-Indolo[3,2,1-de][1,5]naphthyridin-6-one, 5-hydroxy-4-methoxy- | AC-34395 | 4-Methoxy-5-hydroxycanthin-6-one | E806

Storage

Protected from light,Store at -20°C

Shipped In

Ice chest + Ice pads

Panoramica

Nigakinone is one of the most abundant alkaloids responsible for the major pharmacological activities of Kumu.

Form:Solid

Specifiche

Sinonimi

PGFKZUOYIFDMQJ-UHFFFAOYSA-N | 6H-Indolo(3,2,1-de)(1,5)naphthyridin-6-one, 5-hydroxy-4-methoxy- | HMS2269C08 | MLS000574953 | J7E73434D2 | 6H-Indolo[3,2,1-de][1,5]naphthyridin-6-one, 5-hydroxy-4-methoxy- | AC-34395 | 4-Methoxy-5-hydroxycanthin-6-one | E806

Specifiche e purezza

Moligand™,≥98%

Meccanismi biochimici e fisiologici

Nigakinone is one of the most abundant alkaloids responsible for the major pharmacological activities of Kumu.

Condizioni di conservazione di stoccaggio

Protected from light,Store at -20°C

Spedito in

Ice chest + Ice pads

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Grado

Moligand™

Purezza

≥98%

Nomi e identificatori

Sorrisi canonici

COC1=C(C(=O)N2C3=CC=CC=C3C4=C2C1=NC=C4)O

IUPAC Name

3-hydroxy-4-methoxy-1,6-diazatetracyclo[7.6.1.05,16.010,15]hexadeca-3,5(16),6,8,10,12,14-heptaen-2-one

InChIKey

PGFKZUOYIFDMQJ-UHFFFAOYSA-N

INCHI

1S/C15H10N2O3/c1-20-14-11-12-9(6-7-16-11)8-4-2-3-5-10(8)17(12)15(19)13(14)18/h2-7,18H,1H3

Isomeri SMILES

COC1=C(C(=O)N2C3=CC=CC=C3C4=C2C1=NC=C4)O

PubChem CID

5320161

Peso molecolare

266.25

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Alkaloids and derivatives
    • Classe Indolonaphthyridine alkaloids

• Kingdom: Organic compounds
• Superclass: Alkaloids and derivatives
• Classe: Indolonaphthyridine alkaloids
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Indolonaphthyridine alkaloids
• Alternative Parents: Beta carbolines Naphthyridines Indoles Indolizines Alkyl aryl ethers Pyridinones Hydroxypyridines Benzenoids Vinylogous esters Pyrroles Heteroaromatic compounds Lactams Azacyclic compounds Hydrocarbon derivatives Organopnictogen compounds Organonitrogen compounds Organic oxides
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Indolo[3,2-1de][1,5]naphthyridine - Beta-carboline - Pyridoindole - Diazanaphthalene - Naphthyridine - Indole - Indole or derivatives - Indolizine - Pyrrolopyridine - Alkyl aryl ether - Hydroxypyridine - Pyridinone - Pyridine - Benzenoid - Heteroaromatic compound - Vinylogous ester - Pyrrole - Lactam - Azacycle - Ether - Organoheterocyclic compound - Organooxygen compound - Organonitrogen compound - Organic nitrogen compound - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Organic oxygen compound - Aromatic heteropolycyclic compound
• Descrizione: This compound belongs to the class of organic compounds known as indolonaphthyridine alkaloids. These are a numerous and relatively straightforward subgroup of the b-carbolines, e.g. Canthin-6-one, in which an additional C3 unit is attached between C-1 and the indole nitrogen to form an additional ring. The group includes a few dimeric examples, such as Haplophytine.
• External Descriptors: beta-carbolines

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Obiettivi associati (umani)

HepG2 (196354 Activities)

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FEN1 Tchem Flap endonuclease 1 (12055 Activities)

Discover Target: FEN1

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GNAS Tbio Guanine nucleotide-binding protein G(s), subunit alpha (103405 Activities)

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POLI Tchem DNA polymerase iota (116820 Activities)

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KDM4A Tchem Lysine-specific demethylase 4A (52245 Activities)

Discover Target: KDM4A

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EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)

Discover Target: EHMT2

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SMAD3 Tchem Mothers against decapentaplegic homolog 3 (68039 Activities)

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USP1 Tchem Ubiquitin carboxyl-terminal hydrolase 1 (22556 Activities)

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GLS Tchem Glutaminase kidney isoform, mitochondrial (16997 Activities)

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TARDBP Tchem TAR DNA-binding protein 43 (40113 Activities)

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RAN Tchem GTP-binding nuclear protein Ran/Importin subunit beta-1/Snurportin-1 (21853 Activities)

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KPNB1 Tbio Importin subunit beta-1/Snurportin-1 (25097 Activities)

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Obiettivi associati (non umani)

Ptpn1 Protein-tyrosine phosphatase 1B (270 Activities)

Discover Target: Ptpn1

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Plasmodium falciparum (966862 Activities)

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Meriones unguiculatus (417 Activities)

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TGR Thioredoxin glutathione reductase (28579 Activities)

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Meccanismi d'azione

Proprietà chimiche e fisiche

• Solubilità: DMSO : 8.33 mg/mL (31.29 mM; Need ultrasonic)
• Sensibilità: Moisture sensitive.；Light sensitive
• Peso molecolare: 266.250 g/mol
• XLogP3: 2.000
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 266.069 Da
• Monoisotopic Mass: 266.069 Da
• Topological Polar Surface Area: 64.400 Ų
• Heavy Atom Count: 20
• Formal Charge: 0
• Complexity: 476.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1