Pan KRas-IN-1 - ≥98% , CAS No.2791263-84-6

CAS: 2791263-84-6 Cat. No.: P647729 Formula: C₃₃H₃₆F₃N₅O₃ Peso molecolare: 607.67

GRADE & PURITY ≥98%

Storage

Store at 2-8°C,Protected from light,Desiccated

Shipped In

Wet ice

Panoramica

Pan KRas-IN-1 is a pan KRas inhibitor, can be used for agent resistance in cancer developed with KRas G12C inhibitors

In Vitro

Pan KRas-IN-1 (example 5) shows high binding capacity to KRas, with IC 50 s of <2 nM among different KRas isform, including G12D, G12V, G12R, G12A, G12S, G13D, Q61H, and WT. Pan KRas-IN-1 inhibits the phosphorylation of ERK downstream of KRas in different cells; AsPC-1 (G12D, IC 50 =9 nM), A549 (G12S, IC 50 =11 nM), HCT116 (G13D, IC 50 =23 nM), NCI-H358 (G12C, IC 50 =6 nM), NCI-H460 (Q61H, IC 50 =12 nM), NCI-H727 (G12V, IC 50 =29 nM), MKN1 (WT, IC 50 =32 nM), PSN-1 (G12R, IC 50 =681 nM). Pan KRas-IN-1 (0-3000 nM; 5 d) exhibits anti-proliferative activity against mutation of reststance to Adagrasib in mouse 3T3 fibroblasts, with IC 50 s of 32 nM (G12A), 28.1 nM (G12C), 20.25 nM (G12D), 1742 nM (G12R), 94 nM (G12V), 50 nM (G12W), 610 nM (G13D), 58 nM (Q61H). MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:KRas G12D 9 nM (IC 50 ) KRas G12S 11 nM (IC 50 ) KRas G12C 6 nM (IC 50 ) KRas Q61H 12 mM (IC 50 ) KRas G12V 29 mM (IC 50 ) K-Ras WT 32 nM (IC 50 ) K-Ras G12R 681 nM (IC 50 ) K-Ras G13D 23 nM (IC 50 )

Specifications

Specifiche e purezza

≥98%

Meccanismi biochimici e fisiologici

Pan KRas-IN-1 is a pan KRas inhibitor, can be used for agent resistance in cancer developed with KRas G12C inhibitors.

Condizioni di conservazione di stoccaggio

Store at 2-8°C,Protected from light,Desiccated

Spedito in

Wet ice

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Tipo di azione

INHIBITOR

Purezza

≥98%

Nomi e identificatori

Peso molecolare

607.67

Proprietà chimiche e fisiche

• Solubilità: DMSO : 100 mg/mL (164.56 mM; Need ultrasonic)

Domande frequenti

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at 2–8 °C, protected from light, desiccated. Keep the container tightly closed with desiccant — the material is moisture-sensitive.

How is this product shipped?

This product ships chilled on wet ice. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2791263-84-6, the molecular formula is C33H36F3N5O3, and the molecular weight is 607.67 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.