Recombinant PYK2 Antibody - Anticorpo primario, specific to PTK2B, Rabbit IgG
Disponibile
SKU
Ab124023
Recombinant; Rabbit anti Human PTK2B Antibody; WB, IHC; Unconjugated
Rabbit anti Human PTK2B Antibody, Recombinant, could be used for WB, IHC and so on.
Application:
WB: 1/500-1/1000
IHC: 1/50-1/100
IF/ICC: 1/200
Protein Function
Involved in calcium induced regulation of ion channel and activation of the map kinase signaling pathway. May represent an important signaling intermediate between neuropeptide activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. Interacts with the SH2 domain of Grb2. May phosphorylate the voltage-gated potassium channel protein Kv1.2. Its activation is highly correlated with the stimulation of c-Jun N-terminal kinase activity. Involved in osmotic stress-dependent SNCA 'Tyr-125' phosphorylation. In concert with SRC, plays an important role in osteoclastic bone resorption. Both the formation of a SRC-PTK2B complex, and SRC kinase activity are necessary for this function. The Tyr-402 phosphorylated form serves as a docking site for SRC and is important for the organization of the osteoclast actin cytoskeleton and attachment sites and for bone resorption.
Maggiori Informazioni
| Obiettivo | PTK2B |
|---|---|
| Gene Id | 2185 |
| Numero d'ordine | Q14289 |
| Simbolo genico | PTK2B |
| Sinonimi | CADTK antibody | CAK-beta antibody | CAKB antibody | CAKbeta antibody | Calcium regulated non receptor proline rich tyrosine kinase antibody | Calcium-dependent tyrosine kinase antibody | Cell adhesion kinase beta antibody | E430023O05Rik antibody | EC 2. |
| Specifiche e purezza | ExactAb™, Validated, Recombinant, 0.2 mg/mL |
| Specificità | PTK2B |
| Immunogeno | A synthetic peptide derived from human PYK2 (AA 1-19). |
| Controllo positivo | WB: Jurkat, Raji, Ramos and HeLa cell lysates. IHC: Human colon. IF/ICC: HeLa cells. |
| Isotipo | Rabbit IgG |
| Tipo di catena leggera | kappa |
| SDS-PAGE | 150 kD |
| Metodo di purificazione | Protein A purified |
| Concentrazione | 0.2 mg/mL |
| Product Description | Rabbit anti Human PTK2B Antibody, Recombinant, could be used for WB, IHC and so on. Application: WB: 1/500-1/1000 IHC: 1/50-1/100 IF/ICC: 1/200 Protein Function Involved in calcium induced regulation of ion channel and activation of the map kinase signaling pathway. May represent an important signaling intermediate between neuropeptide activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. Interacts with the SH2 domain of Grb2. May phosphorylate the voltage-gated potassium channel protein Kv1.2. Its activation is highly correlated with the stimulation of c-Jun N-terminal kinase activity. Involved in osmotic stress-dependent SNCA 'Tyr-125' phosphorylation. In concert with SRC, plays an important role in osteoclastic bone resorption. Both the formation of a SRC-PTK2B complex, and SRC kinase activity are necessary for this function. The Tyr-402 phosphorylated form serves as a docking site for SRC and is important for the organization of the osteoclast actin cytoskeleton and attachment sites and for bone resorption. |
| Forma | Liquid |
| Condizioni di conservazione di stoccaggio | Store at -20°C,Avoid repeated freezing and thawing |
| Spedito in | Ice chest + Ice pads |
| Stabilità e conservazione | Store at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle. |
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