(S)-3,4-DCPG - Moligand™, ≥99% , Agonist of mGlu 4 receptor;Agonist of mGlu 6 receptor;Agonist of mGlu 8 receptor, CAS No.201730-11-2, Agonist of mGlu 4 receptor;Agonist of mGlu 6 receptor;Agonist of mGlu 8 receptor

CAS: 201730-11-2 Cat. No.: D274980 Formula: C₁₀H₉NO₆ Peso molecolare: 239.18 Numero EC: 633-834-4

GRADE & PURITY Moligand™, ≥99%

Synonyms

(s)-3,4dicarboxyphenylglycine | FT-0707334 | UBP 1109 | AC-30407 | J-013084 | (S)-3,4-DCPG | HMS3412E16 | HMS3676E16 | AT33390 | 4-[(S)-amino(carboxy)methyl]phthalic acid | BDBM50138783 | 4-((S)-Amino-carboxy-methyl)-phthalic acid | benzyl 4-(tetramethyl-

Storage

Store at -20°C,Desiccated

Shipped In

Cassetta del ghiaccio + cuscini per il ghiaccio

Specifications

Sinonimi

(s)-3,4dicarboxyphenylglycine | FT-0707334 | UBP 1109 | AC-30407 | J-013084 | (S)-3,4-DCPG | HMS3412E16 | HMS3676E16 | AT33390 | 4-[(S)-amino(carboxy)methyl]phthalic acid | BDBM50138783 | 4-((S)-Amino-carboxy-methyl)-phthalic acid | benzyl 4-(tetramethyl-

Specifiche e purezza

Moligand™, ≥99%

Meccanismi biochimici e fisiologici

Agonista mGlu 8a potente e selettivo (EC 50 = 31 nM). Mostra una selettività >100 volte superiore a quella di mGlu 1-7. Attivo a livello sistemico in vivo. Disponibile anche in semplici soluzioni stock, aggiungere 1 ml di acqua per ottenere una concentraz

Condizioni di conservazione di stoccaggio

Store at -20°C,Desiccated

Spedito in

Cassetta del ghiaccio + cuscini per il ghiaccio

Grado

Moligand™

Tipo di azione

AGONIST

Meccanismo d'azione

Agonist of mGlu 4 receptor;Agonist of mGlu 6 receptor;Agonist of mGlu 8 receptor

Nota

Per quanto possibile, si consiglia di preparare e utilizzare le soluzioni lo stesso giorno. Tuttavia, se è necessario preparare in anticipo le soluzioni di riserva, si consiglia di conservarle in aliquote in fiale ben chiuse a -20°C. In genere, queste possono essere utilizzate per un mese. In genere, queste soluzioni sono utilizzabili fino a un mese. Prima dell'uso e dell'apertura della fiala, si consiglia di lasciare che il prodotto si equilibri a temperatura ambiente per almeno 1 ora. Avete bisogno di ulteriori consigli su solubilità, uso e manipolazione? Per ulteriori informazioni, visitare la pagina delle domande frequenti (FAQ).

Purezza

≥99%

Nomi e identificatori

• Pubchem Sid: 528753372
• Sorrisi canonici: C1=CC(=C(C=C1C(C(=O)O)N)C(=O)O)C(=O)O
• IUPAC Name: 4-[(S)-amino(carboxy)methyl]phthalic acid
• InChIKey: IJVMOGKBEVRBPP-ZETCQYMHSA-N
• INCHI: 1S/C10H9NO6/c11-7(10(16)17)4-1-2-5(8(12)13)6(3-4)9(14)15/h1-3,7H,11H2,(H,12,13)(H,14,15)(H,16,17)/t7-/m0/s1
• Isomeri SMILES: C1=CC(=C(C=C1[C@@H](C(=O)O)N)C(=O)O)C(=O)O
• Peso molecolare: 239.18
• Reaxy-Rn: 8421991
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=8421991&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Classe Carboxylic acids and derivatives
      • Subclass Amino acids, peptides, and analogues
        • Level5 Amino acids and derivatives
          • Level6 Alpha amino acids and derivatives
            • Level7 Alpha amino acids
              • Level8 L-alpha-amino acids

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Classe: Carboxylic acids and derivatives
• Subclass: Amino acids, peptides, and analogues
• Intermediate Tree Nodes: Amino acids and derivatives - Alpha amino acids and derivatives - Alpha amino acids
• Direct Parent: L-alpha-amino acids
• Alternative Parents: Benzoic acids Benzoyl derivatives Aralkylamines Amino acids Monocarboxylic acids and derivatives Carboxylic acids Organic oxides Monoalkylamines Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aromatic homomonocyclic compounds
• Substituents: L-alpha-amino acid - Benzoic acid or derivatives - Benzoic acid - Benzoyl - Aralkylamine - Monocyclic benzene moiety - Benzenoid - Amino acid - Carboxylic acid - Monocarboxylic acid or derivatives - Hydrocarbon derivative - Organonitrogen compound - Organooxygen compound - Primary aliphatic amine - Primary amine - Carbonyl group - Amine - Organic oxygen compound - Organic nitrogen compound - Organic oxide - Aromatic homomonocyclic compound
• Descrizione: This compound belongs to the class of organic compounds known as l-alpha-amino acids. These are alpha amino acids which have the L-configuration of the alpha-carbon atom.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

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GRM4 Tchem Metabotropic glutamate receptor 4 (1 Activities)

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GRM8 Tchem Metabotropic glutamate receptor 8 (4 Activities)

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GRM6 Tchem Metabotropic glutamate receptor 6 (1 Activities)

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ABL1 Tclin Tyrosine-protein kinase ABL (18331 Activities)

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ADRB2 Tclin Beta-2 adrenergic receptor (11824 Activities)

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ADRA2A Tclin Alpha-2a adrenergic receptor (9450 Activities)

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AGTR1 Tclin Type-1 angiotensin II receptor (5176 Activities)

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GRM3 Tchem Metabotropic glutamate receptor 3 (732 Activities)

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GSK3B Tclin Glycogen synthase kinase-3 beta (11785 Activities)

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CSNK1D Tchem Casein kinase I delta (4546 Activities)

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GRM4 Tchem Metabotropic glutamate receptor 4 (2320 Activities)

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GRM6 Tchem Metabotropic glutamate receptor 6 (361 Activities)

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GRM1 Tchem Metabotropic glutamate receptor 1 (2309 Activities)

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GRM5 Tchem Metabotropic glutamate receptor 5 (5733 Activities)

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S1PR1 Tclin Sphingosine 1-phosphate receptor Edg-1 (5806 Activities)

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CDK2 Tchem Cyclin-dependent kinase 2 (9050 Activities)

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C5AR1 Tclin C5a anaphylatoxin chemotactic receptor (2677 Activities)

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U2OS (164939 Activities)

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HEK-293T (167025 Activities)

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Grm2 Metabotropic glutamate receptor 2 (1326 Activities)

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Mapk1 MAP kinase ERK2 (650 Activities)

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Hdac6 Histone deacetylase 6 (222 Activities)

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Fgfr3 Fibroblast growth factor receptor 3 (21 Activities)

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rep Replicase polyprotein 1ab (378 Activities)

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Gpr119 Glucose-dependent insulinotropic receptor (270 Activities)

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SARS-CoV-2 (38078 Activities)

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Meccanismi d'azione

Proprietà chimiche e fisiche

• Solubilità: Soluble in water to 100 mM;DMF: 25 mg/ml;DMSO: 20 mg/ml;Ethanol: 33 mg/ml;PBS (pH 7.2): 10 mg/ml
• Peso molecolare: 239.180 g/mol
• XLogP3: -2.700
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 4
• Exact Mass: 239.043 Da
• Monoisotopic Mass: 239.043 Da
• Topological Polar Surface Area: 138.000 Ų
• Heavy Atom Count: 17
• Formal Charge: 0
• Complexity: 342.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 1
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1